MYOCARDIAL SCANNING WITH $sup 82$Rb. Page: 3 of 10
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The clinical importance of visualizing myocardial infarcts has
prompted the investigation of several isotopes as possible cardiac
scanning agents. Carr and associates (1, 2) have shown that both
rubidium and cesium concentrate in the normal myocardium. The high
energy gamma of 86Rb (1.08 MeV) makes it unsuitable for scanning an organ
the size of the heart, 1310s decays by electron capture and produces
a 29.4 KeV X-ray. Myocardial scans obtained with 1310s and commercially
available scanners are good except for marked soft tissue attenuation
and rib shadows due to the very low energy cf the emitted radiation.
With the superior resolution of the positron camera and a good
positron emitting isotope, the quality of myocardial scans might be
significantly improved. Positron-emitting isotopes of rubidium have
been studied. Both 84Rb (half life, 33 days) and 82b (half life, 75
seconds) have been evaluated in dogs, with and without acute coronary
artery ligation. While both isotopes allow clear visualization of the
heart (infarcted tissue appears as an area of decreased isotope uptake),
, shown in Figure 1, is preferable for several reasons: 1) its
short half life allows repeated studies without background buildup and
very little radiation dose to the subject; 2) its greater abundance of
positron emission (96% compared to 19% for 84Th); and 3) it is easily
obtained from its parent isotope, Sr, by elution from an ion exchange
resin (3). 82Sr (half life, 25 5 days) is cyclotron produced via 85Rb
(p, 4n) Sr.
A specially constructed ion-exchange column was made of Pyrex
glass 11 mm i.d. and 60 mm high. Bio-Rex 70 of 100 to 200-mesh particle
size was slurried into the ion-exchange column and washed with 0.3 M
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Bokelman, J.; Van Dyke, D.; Yano, Y. & Anger, H. MYOCARDIAL SCANNING WITH $sup 82$Rb., report, January 1, 1972; Berkeley, California. (https://digital.library.unt.edu/ark:/67531/metadc1032549/m1/3/: accessed March 26, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.