Radiobiological Basis for the Whole Body Radiation Syndrome

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Data are presented that show a marked species difference in the degree of damage and in the course of events seen in the bone marrow and peripheral blood after a given dose of radiation. The data taken together indicate strongly, but do not prove, that the picture seen results primarily from damage to the stem cell population. This damage to the stem cells is manifested later in the more mature differentiating cells of the marrow, and in the peripheral blood. The picture seen results both from death of stem cells, and also injury leading to reduced proliferative capacity, with later ... continued below

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23 pages

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Bond, V.P. & Fliedner, T.M. July 19, 1963.

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Description

Data are presented that show a marked species difference in the degree of damage and in the course of events seen in the bone marrow and peripheral blood after a given dose of radiation. The data taken together indicate strongly, but do not prove, that the picture seen results primarily from damage to the stem cell population. This damage to the stem cells is manifested later in the more mature differentiating cells of the marrow, and in the peripheral blood. The picture seen results both from death of stem cells, and also injury leading to reduced proliferative capacity, with later death of the injured stem cell and all of its progeny. Thus the picture seen is a result of both quantitative and qualitative changes resulting directly from the exposure of the stem cells, and species differences relative to sensitivity and time course of events appear to depend to a large degree on differential sensitivity of the bone marrow stem cell populations to death and injury. (auth)

Physical Description

23 pages

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OSTI as DE04635224

Source

  • Joint Meeting of the German Roentgen Society and the German Biophysical Society, Baden-Baden (DE), 04/1963

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  • Report No.: BNL-7207
  • Report No.: CONF-236-1
  • Grant Number: AT-30-2-GEN-16
  • Office of Scientific & Technical Information Report Number: 4635224
  • Archival Resource Key: ark:/67531/metadc1028498

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • July 19, 1963

Added to The UNT Digital Library

  • Oct. 18, 2017, 7:39 a.m.

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  • Oct. 31, 2017, 2:15 p.m.

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Bond, V.P. & Fliedner, T.M. Radiobiological Basis for the Whole Body Radiation Syndrome, article, July 19, 1963; United States. (digital.library.unt.edu/ark:/67531/metadc1028498/: accessed December 14, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.