A STUDY OF THE TISSUE RESPONSE TO STERILE DEPOSITS OF PARTICULATE MATERIAL

PDF Version Also Available for Download.

Description

Thirty-seven sterile materials of common construction usage, common lubricants, and samples of wearing apparel were injected as finely divided particles into the subcutaneous soft tissues of guinea pigs, each in six different sites. At intervals of 3, 7, 14, 21, 30, 65, or 90 days, an inoculation site of each material was excised, in toto, fixed, and examined microscopically. In addition, ten selected materials were injected into the liver and spleen and deposited on the omentum and mesentery of four guinea pigs for each material type. At intervals of 7, 14, 21, and 30 days, one of each group of ... continued below

Physical Description

Pages: 107

Creation Information

Chiffelle, T.L.; Sherping, F.; Goldizen, V.C. & White, C.S. October 1, 1957.

Context

This report is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. More information about this report can be viewed below.

Who

People and organizations associated with either the creation of this report or its content.

Provided By

UNT Libraries Government Documents Department

Serving as both a federal and a state depository library, the UNT Libraries Government Documents Department maintains millions of items in a variety of formats. The department is a member of the FDLP Content Partnerships Program and an Affiliated Archive of the National Archives.

Contact Us

What

Descriptive information to help identify this report. Follow the links below to find similar items on the Digital Library.

Description

Thirty-seven sterile materials of common construction usage, common lubricants, and samples of wearing apparel were injected as finely divided particles into the subcutaneous soft tissues of guinea pigs, each in six different sites. At intervals of 3, 7, 14, 21, 30, 65, or 90 days, an inoculation site of each material was excised, in toto, fixed, and examined microscopically. In addition, ten selected materials were injected into the liver and spleen and deposited on the omentum and mesentery of four guinea pigs for each material type. At intervals of 7, 14, 21, and 30 days, one of each group of four animals was sacrificed and a block of tissue containing the inoculum was removed from the tissues and organs, fixed, and examined histologically. The majority of materials induced only a mild and delayed inflammatory response followed by encapsulation at the end of 14 days and a relatively inert fibrous nodule produced by the 2lst or 30th day. Copper particles incited a marked inflammatory response with abscess formation which persisted until the 90th day, although showing signs of subsiding at this time. Cudmium lesions were characterized by a peculiar zone of necrosis about the particle aggregate which persisted until the 60th day. Duraluminum of one type incited a pseudoneoplastic fibrous response. Axle grease, in the early stages, induced one of the most intense acute inflummations, in contrast to that produced by motor oil and ordinary lubricating grease, but the process had subsided and was fibrosed by the end of 30 days. (auth)

Physical Description

Pages: 107

Notes

NTIS

Source

  • Other Information: Orig. Receipt Date: 31-DEC-58

Language

Item Type

Identifier

Unique identifying numbers for this report in the Digital Library or other systems.

  • Report No.: AECU-3574
  • Grant Number: AT(29-1)-1242
  • DOI: 10.2172/4340923 | External Link
  • Office of Scientific & Technical Information Report Number: 4340923
  • Archival Resource Key: ark:/67531/metadc1025468

Collections

This report is part of the following collection of related materials.

Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

What responsibilities do I have when using this report?

When

Dates and time periods associated with this report.

Creation Date

  • October 1, 1957

Added to The UNT Digital Library

  • Oct. 15, 2017, 10:09 p.m.

Usage Statistics

When was this report last used?

Congratulations! It looks like you are the first person to view this item online.

Interact With This Report

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

International Image Interoperability Framework

IIF Logo

We support the IIIF Presentation API

Chiffelle, T.L.; Sherping, F.; Goldizen, V.C. & White, C.S. A STUDY OF THE TISSUE RESPONSE TO STERILE DEPOSITS OF PARTICULATE MATERIAL, report, October 1, 1957; United States. (digital.library.unt.edu/ark:/67531/metadc1025468/: accessed August 16, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.