THE EFFECTS OF SOME LOCALLY APPLIED MEDICATIONS ON THE HEALING OF SECOND DEGREE BURNS

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The possibility of evaluating experimentally the effects of locally applied medications on the rate of burn healing was explored. Twenty or 24 small burns were produced on each of eight anesthelized Chester White pigs by an exposure of 10 calories per square centimeter delivered ln 3 seconds. In earlier studies it had been found that lesions from this exposure are moderate second degree burns which, if untreated, are completelly covered wiih new epithelium in 14 days. Nine days after injury, less than half of them exhibit this degree of healing. The five medicated ointments tested were applied to randomized burns ... continued below

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Pages: 15

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Hinshaw, J.R. & Pearse, H.E. January 15, 1958.

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Description

The possibility of evaluating experimentally the effects of locally applied medications on the rate of burn healing was explored. Twenty or 24 small burns were produced on each of eight anesthelized Chester White pigs by an exposure of 10 calories per square centimeter delivered ln 3 seconds. In earlier studies it had been found that lesions from this exposure are moderate second degree burns which, if untreated, are completelly covered wiih new epithelium in 14 days. Nine days after injury, less than half of them exhibit this degree of healing. The five medicated ointments tested were applied to randomized burns once a day for five days. After four days without treatment, the burns were biopsied. The degree of epithelial coverage was evaluated microscopically, and the results in treated and untreated areas were compared. None of the medications significantly promoted or delayed epithelial regeneration. Variations in healing rate from one animal to another and in different anatomical locations on the same animal were noted. These findings should affect the design of any experiment to determine the effects of treatment on healing. (auth)

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Pages: 15

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  • Other Information: Orig. Receipt Date: 31-DEC-58

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  • Report No.: UR-518
  • Grant Number: W-7401-ENG-49
  • Office of Scientific & Technical Information Report Number: 4327119
  • Archival Resource Key: ark:/67531/metadc1024853

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  • January 15, 1958

Added to The UNT Digital Library

  • Oct. 15, 2017, 10:09 p.m.

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  • Oct. 20, 2017, 3:09 p.m.

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Hinshaw, J.R. & Pearse, H.E. THE EFFECTS OF SOME LOCALLY APPLIED MEDICATIONS ON THE HEALING OF SECOND DEGREE BURNS, report, January 15, 1958; United States. (digital.library.unt.edu/ark:/67531/metadc1024853/: accessed October 15, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.