INHALATION TOXICITY OF ZIRCONIUM COMPOUNDS. I. SHORT-TERM STUDIES

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A total of 270 animals of 5 species was exposed by inhalation to compounds of zirconium for 6 hours per day, 5 days per week. One group of animals was exposed to ZrO{sub 2} at an atmospheric concentration of 75 mg. Zr/m{sup 3} for 30 days; another, to 11 mg. Zr/m{sup 3} for 60 days. A third group was exposed to a mist of ZrCl{sub 4} at a level of 6 mg. Zr/m{sup 3} for 60 days. Zirconium oxide produced no significant changes in mortality, growth rate, blood nonprotein nitrogen or fibrinogen, urinary protein, hematological values or histological structure. Zirconium ... continued below

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Pages: 26

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Spiegl, C.J.; Calkins, M.C.; DeVoldre, J.J.; Scott, J.K.; Steadman, L.T. & Stokinger, H.E. July 31, 1956.

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Description

A total of 270 animals of 5 species was exposed by inhalation to compounds of zirconium for 6 hours per day, 5 days per week. One group of animals was exposed to ZrO{sub 2} at an atmospheric concentration of 75 mg. Zr/m{sup 3} for 30 days; another, to 11 mg. Zr/m{sup 3} for 60 days. A third group was exposed to a mist of ZrCl{sub 4} at a level of 6 mg. Zr/m{sup 3} for 60 days. Zirconium oxide produced no significant changes in mortality, growth rate, blood nonprotein nitrogen or fibrinogen, urinary protein, hematological values or histological structure. Zirconium tetrachloride at 6 mg. Zr/m{sup 3} gave questionable changes in blood hemoglobin concentration and red cell counts of dogs and a slight increase in mortality of rats and guinea pigs. Inhaled zirconium compounds deposited primarily in the lung and pulmonary lymph node, with a fraction of a per cent in the bone and considerably less in the soft tissues. (auth)

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Pages: 26

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  • Other Information: Orig. Receipt Date: 31-DEC-56

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  • Report No.: UR-460
  • Grant Number: W-7401-ENG-49
  • DOI: 10.2172/4353129 | External Link
  • Office of Scientific & Technical Information Report Number: 4353129
  • Archival Resource Key: ark:/67531/metadc1024703

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  • July 31, 1956

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  • Oct. 15, 2017, 10:09 p.m.

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Spiegl, C.J.; Calkins, M.C.; DeVoldre, J.J.; Scott, J.K.; Steadman, L.T. & Stokinger, H.E. INHALATION TOXICITY OF ZIRCONIUM COMPOUNDS. I. SHORT-TERM STUDIES, report, July 31, 1956; United States. (digital.library.unt.edu/ark:/67531/metadc1024703/: accessed November 20, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.