Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk

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This review article will focus on known risks following iron oxide nanoparticles (IONPs) exposure supported by human, animal, and cell culture-based studies, the potential challenges intrinsic to IONPs toxicity assessment, and how these may contribute to the poorly characterized IONPs toxicity profile.

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26 p.

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Kornberg, Tiffany G.; Stueckle, Todd A.; Antonini, James M.; Rojanasakul, Liying W.; Castranova, Vincent; Yang, Yong et al. October 6, 2017.

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This article is part of the collection entitled: UNT Scholarly Works and was provided by UNT College of Engineering to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 11 times . More information about this article can be viewed below.

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The UNT College of Engineering promotes intellectual and scholarly pursuits in the areas of computer science and engineering, preparing innovative leaders in a variety of disciplines. The UNT College of Engineering encourages faculty and students to pursue interdisciplinary research among numerous subjects of study including databases, numerical analysis, game programming, and computer systems architecture.

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Description

This review article will focus on known risks following iron oxide nanoparticles (IONPs) exposure supported by human, animal, and cell culture-based studies, the potential challenges intrinsic to IONPs toxicity assessment, and how these may contribute to the poorly characterized IONPs toxicity profile.

Physical Description

26 p.

Notes

Abstract: Fine/micron-sized iron oxide particulates are incidentally released from a number of industrial processes, including iron ore mining, steel processing, welding, and pyrite production. Some research suggests that occupational exposure to these particulates is linked to an increased risk of adverse respiratory outcomes, whereas other studies suggest that iron oxide is biologically benign. Iron oxide nanoparticles (IONPs), which are less than 100 nm in diameter, have recently surged in use as components of novel drug delivery systems, unique imaging protocols, as environmental catalysts, and for incorporation into thermoplastics. However, the adverse outcomes associated with occupational exposure to IONPs remain relatively unknown. Relevant in vivo studies suggest that pulmonary exposure to IONPs may induce inflammation, pulmonary fibrosis, genotoxicity, and extra-pulmonary effects. This correlates well with in vitro studies that utilize relevant dose, cell type(s), and meaningful end points. A majority of these adverse outcomes are attributed to increased oxidative stress, most likely caused by particle internalization, dissolution, release of free iron ions, and disruption of iron homeostasis. However, because the overall toxicity profile of IONPs is not well understood, it is difficult to set safe exposure limit recommendations that would be adequate for the protection of at-risk workers. This review article will focus on known risks following IONPs exposure supported by human, animal, and cell culture-based studies, the potential challenges intrinsic to IONPs toxicity assessment, and how these may contribute to the poorly characterized IONPs toxicity profile.

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  • Nanomaterials, 2017. Basel, Switzerland: Multidisciplinary Digital Publishing Institute

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  • Publication Title: Nanomaterials
  • Volume: 7
  • Pages: 1-26
  • Peer Reviewed: Yes

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UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

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  • September 7, 2017

Accepted Date

  • September 28, 2017

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  • October 6, 2017

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  • Oct. 14, 2017, 9:21 p.m.

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Kornberg, Tiffany G.; Stueckle, Todd A.; Antonini, James M.; Rojanasakul, Liying W.; Castranova, Vincent; Yang, Yong et al. Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk, article, October 6, 2017; Basel, Switzerland. (digital.library.unt.edu/ark:/67531/metadc1020990/: accessed April 24, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Engineering.