Culture of normal and leukemic cells in diffusion chambers

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Normal murine, caprine, and human bone marrow and peripheral blood cells can be grown in diffusion chambers. The irradiated host provides a stimulus to erythrocytic and granulocytic growth over what is seen in the DC's implanted in the nonirradiated host. The stimulus is most likely humoral and affects erythropoiesis, granulopoiesis, and megakaryocytopoiesis. It is suggested but not proved that the stimulus for erythropoiesis is an increased level of plasma erythropoietin. It is tempting to suggest that CSF and thrombopoietin are responsible for the stimulation of the other cell lines. Growth of normal human cells in irradiated mice shows a marked ... continued below

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Pages: 27

Creation Information

Cronkite, E.P.; Carsten, A.L.; Chikkappa, G.; Laissue, J.A. & Oehl, S. January 1, 1973.

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Description

Normal murine, caprine, and human bone marrow and peripheral blood cells can be grown in diffusion chambers. The irradiated host provides a stimulus to erythrocytic and granulocytic growth over what is seen in the DC's implanted in the nonirradiated host. The stimulus is most likely humoral and affects erythropoiesis, granulopoiesis, and megakaryocytopoiesis. It is suggested but not proved that the stimulus for erythropoiesis is an increased level of plasma erythropoietin. It is tempting to suggest that CSF and thrombopoietin are responsible for the stimulation of the other cell lines. Growth of normal human cells in irradiated mice shows a marked reduction of the transit time from the myelocyte to the segmented neutrophils. Growth does not follow steady conditions in terms of rates and transit times. Since all cells produced are retained in the DC's after the time they would normally be extruded into the blood, a nonsteady state system exists. Senescent death of non-proliferating cells occurs. Human leukemic and multiple myeloma cells grow in DC's as do blood cells from patients with myelofibrosis and myeloid metaplasia. Data are insufficient to characterize aberrations in growth. Pilot studies show that human eosinophils will grow, proliferate and mature. (auth)

Physical Description

Pages: 27

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Dep. NTIS

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  • Other Information: Orig. Receipt Date: 30-JUN-74

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  • Report No.: BNL--18319
  • Grant Number: None
  • DOI: 10.2172/4407071 | External Link
  • Office of Scientific & Technical Information Report Number: 4407071
  • Archival Resource Key: ark:/67531/metadc1020453

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

  • January 1, 1973

Added to The UNT Digital Library

  • Oct. 15, 2017, 10:09 p.m.

Description Last Updated

  • Oct. 25, 2017, 7:08 p.m.

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Cronkite, E.P.; Carsten, A.L.; Chikkappa, G.; Laissue, J.A. & Oehl, S. Culture of normal and leukemic cells in diffusion chambers, report, January 1, 1973; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc1020453/: accessed September 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.