Measurement of ''closing volume'' as affected by lung volume at tracer bolus inspiration, breath holding, and expiratory flow rate

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From international symposium on regional lung function and closing volumes; Malmo, Sweden (14 Sep 1973). The measurement of closing volume is of great interest in the early detection of diseases of the small airways, especially if this technique can be used for mass screening with mobile equipment. The basis undenlying the closing volume measurement involves either the inspiration of a tracer gas bolus, such as radioactive /sup 133/Xe or /sup 13/N or stable argon or helium, followed by measurement of the tracer concentration in the expirate, or analysis of the expirate for nitrogen, following a vital capacity (VC) inspiration of ... continued below

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Pages: 13

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Susskind, H.; Richards, P. & Atkins, H.L. January 1, 1973.

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Description

From international symposium on regional lung function and closing volumes; Malmo, Sweden (14 Sep 1973). The measurement of closing volume is of great interest in the early detection of diseases of the small airways, especially if this technique can be used for mass screening with mobile equipment. The basis undenlying the closing volume measurement involves either the inspiration of a tracer gas bolus, such as radioactive /sup 133/Xe or /sup 13/N or stable argon or helium, followed by measurement of the tracer concentration in the expirate, or analysis of the expirate for nitrogen, following a vital capacity (VC) inspiration of pure oxygen. The point (expired volume) at which the alveolar gas concentration changes discretely from the alveolar plateau, Phase III, to Phase IV is denoted as the closing volume, and is believed to represent the onset of closure of the dependent airways. The mechanisms involved were studied in four healthy young human volunteers following the inhalation of a 1-ml bolus of helium. (CH)

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Pages: 13

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  • International symposium on regional lung function and closing volumes, Malmo, Sweden, 14 Sep 1973

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  • Report No.: BNL--18198
  • Report No.: CONF-730950--1
  • Grant Number: None
  • Office of Scientific & Technical Information Report Number: 4389001
  • Archival Resource Key: ark:/67531/metadc1016435

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • January 1, 1973

Added to The UNT Digital Library

  • Oct. 15, 2017, 10:09 p.m.

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  • Oct. 25, 2017, 10:19 p.m.

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Susskind, H.; Richards, P. & Atkins, H.L. Measurement of ''closing volume'' as affected by lung volume at tracer bolus inspiration, breath holding, and expiratory flow rate, article, January 1, 1973; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc1016435/: accessed December 11, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.