THE INTERACTIONS. OF 4-NITROQUINOLINE-1-OXIDE WITH FOUR DEOXYRIBONUCLEOTIDES

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The interactions of 4-nitroquinoline-1-oxide (NQO) with the four 5{prime}-deoxyribonucleotides were probed using absorption spectra of the charge transfer bands and {sup 1}H and {sup 13}C NMR spectra of nucleotide-NQO mixtures. Applying a Benesi-Hildebrand type equation to the spectral data yielded equilibrium constants (K(dpG:NQO) = 16 M{sup -1} K(dpA:NQO) = 12 M{sup -1}, K(dpT:NQO) = K(dpC:NQO) = 4 M{sup -1}) which suggest the preference of NQO for the guanine residue in a DNA. From {sup 13}C and {sup 1}H NMR data, a structure for the dpG:NQO complex is proposed.

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34 p.

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Winkle, S.A. & Tinoco Jr, I. September 1, 1977.

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The interactions of 4-nitroquinoline-1-oxide (NQO) with the four 5{prime}-deoxyribonucleotides were probed using absorption spectra of the charge transfer bands and {sup 1}H and {sup 13}C NMR spectra of nucleotide-NQO mixtures. Applying a Benesi-Hildebrand type equation to the spectral data yielded equilibrium constants (K(dpG:NQO) = 16 M{sup -1} K(dpA:NQO) = 12 M{sup -1}, K(dpT:NQO) = K(dpC:NQO) = 4 M{sup -1}) which suggest the preference of NQO for the guanine residue in a DNA. From {sup 13}C and {sup 1}H NMR data, a structure for the dpG:NQO complex is proposed.

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34 p.

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  • Journal Name: Journal of Biochemistry

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  • Report No.: LBL-6759
  • Grant Number: DE-AC02-05CH11231
  • Office of Scientific & Technical Information Report Number: 983258
  • Archival Resource Key: ark:/67531/metadc1015150

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  • September 1, 1977

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  • Oct. 14, 2017, 8:36 a.m.

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  • Oct. 18, 2017, 10:08 a.m.

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Winkle, S.A. & Tinoco Jr, I. THE INTERACTIONS. OF 4-NITROQUINOLINE-1-OXIDE WITH FOUR DEOXYRIBONUCLEOTIDES, article, September 1, 1977; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc1015150/: accessed June 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.