Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones

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The changes in tissue architecture that accompany the development of breast cancer have been the focus of investigations aimed at developing new cancer therapeutics. As we learn more about the normal mammary gland, we have begun to understand the complex signaling pathways underlying the dramatic shifts in the structure and function of breast tissue. Integrin-, growth factor-, and steroid hormone-signaling pathways all play an important part in maintaining tissue architecture; disruption of the delicate balance of signaling results in dramatic changes in the way cells interact with each other and with the extracellular matrix, leading to breast cancer. The extracellular … continued below

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Hansen, R K & Bissell, M J June 1, 2000.

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This article is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by the UNT Libraries Government Documents Department to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 42 times. More information about this article can be viewed below.

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The changes in tissue architecture that accompany the development of breast cancer have been the focus of investigations aimed at developing new cancer therapeutics. As we learn more about the normal mammary gland, we have begun to understand the complex signaling pathways underlying the dramatic shifts in the structure and function of breast tissue. Integrin-, growth factor-, and steroid hormone-signaling pathways all play an important part in maintaining tissue architecture; disruption of the delicate balance of signaling results in dramatic changes in the way cells interact with each other and with the extracellular matrix, leading to breast cancer. The extracellular matrix itself plays a central role in coordinating these signaling processes. In this review, we consider the interrelationships between the extracellular matrix, integrins, growth factors, and steroid hormones in mammary gland development and function.

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  • Journal Name: Endocrine-Related Cancer; Journal Volume: 7; Journal Issue: 2; Related Information: Journal Publication Date: 6/2000

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  • June 1, 2000

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  • Oct. 14, 2017, 8:36 a.m.

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  • March 19, 2019, 6 p.m.

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Hansen, R K & Bissell, M J. Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones, article, June 1, 2000; Berkeley, California. (https://digital.library.unt.edu/ark:/67531/metadc1014444/: accessed April 19, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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