Single cell analysis: the new frontier in 'Omics'

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Cellular heterogeneity arising from stochastic expression of genes, proteins, and metabolites is a fundamental principle of cell biology, but single cell analysis has been beyond the capabilities of 'Omics' technologies. This is rapidly changing with the recent examples of single cell genomics, transcriptomics, proteomics, and metabolomics. The rate of change is expected to accelerate owing to emerging technologies that range from micro/nanofluidics to microfabricated interfaces for mass spectrometry to third- and fourth-generation automated DNA sequencers. As described in this review, single cell analysis is the new frontier in Omics, and single cell Omics has the potential to transform systems biology ... continued below

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Wang, Daojing & Bodovitz, Steven January 14, 2010.

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Cellular heterogeneity arising from stochastic expression of genes, proteins, and metabolites is a fundamental principle of cell biology, but single cell analysis has been beyond the capabilities of 'Omics' technologies. This is rapidly changing with the recent examples of single cell genomics, transcriptomics, proteomics, and metabolomics. The rate of change is expected to accelerate owing to emerging technologies that range from micro/nanofluidics to microfabricated interfaces for mass spectrometry to third- and fourth-generation automated DNA sequencers. As described in this review, single cell analysis is the new frontier in Omics, and single cell Omics has the potential to transform systems biology through new discoveries derived from cellular heterogeneity.

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  • Report No.: LBNL-3480E
  • Grant Number: DE-AC02-05CH11231
  • DOI: 10.2172/983315 | External Link
  • Office of Scientific & Technical Information Report Number: 983315
  • Archival Resource Key: ark:/67531/metadc1014258

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  • January 14, 2010

Added to The UNT Digital Library

  • Oct. 14, 2017, 8:36 a.m.

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  • Oct. 18, 2017, 10:11 a.m.

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Wang, Daojing & Bodovitz, Steven. Single cell analysis: the new frontier in 'Omics', report, January 14, 2010; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc1014258/: accessed November 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.