Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1

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An intact basement membrane (BM) is essential for the proper function, differentiation and morphology of many epithelial cells. The disruption or loss of this BM occurs during normal development as well as in the disease state. To examine the importance of BM during mammary gland development in vivo, we generated transgenic mice that inappropriately express autoactivating isoforms of the matrix metalloproteinase stromelysin-1. The mammary glands from these mice are both functionally and morphologically altered throughout development. We have now documented a dramatic incidence of breast tumors in several independent lines of these mice. These data suggest that overexpression of stromelysin-1 ... continued below

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Sympson, Carolyn J; Bissell, Mina J & Werb, Zena June 1, 1995.

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An intact basement membrane (BM) is essential for the proper function, differentiation and morphology of many epithelial cells. The disruption or loss of this BM occurs during normal development as well as in the disease state. To examine the importance of BM during mammary gland development in vivo, we generated transgenic mice that inappropriately express autoactivating isoforms of the matrix metalloproteinase stromelysin-1. The mammary glands from these mice are both functionally and morphologically altered throughout development. We have now documented a dramatic incidence of breast tumors in several independent lines of these mice. These data suggest that overexpression of stromelysin-1 and disruption of the BM may be a key step in the multi-step process of breast cancer.

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  • Journal Name: Seminars in Cancer Biology; Journal Volume: 6; Journal Issue: 3; Related Information: Journal Publication Date: 6/1/1995

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  • Report No.: LBNL-3949E
  • Grant Number: DE-AC02-05CH11231
  • Grant Number: DE-AC03-76-SF01012, DE-AC03-76-SF00098, NCI CA 57621
  • DOI: 10.1006/scbi.1995.0022 | External Link
  • Office of Scientific & Technical Information Report Number: 989228
  • Archival Resource Key: ark:/67531/metadc1014061

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  • June 1, 1995

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  • Oct. 14, 2017, 8:36 a.m.

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  • Oct. 18, 2017, 10:32 a.m.

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Sympson, Carolyn J; Bissell, Mina J & Werb, Zena. Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1, article, June 1, 1995; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc1014061/: accessed July 17, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.