The Autonomous Pathogen Detection System

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We developed, tested, and now operate a civilian biological defense capability that continuously monitors the air for biological threat agents. The Autonomous Pathogen Detection System (APDS) collects, prepares, reads, analyzes, and reports results of multiplexed immunoassays and multiplexed PCR assays using Luminex{copyright} xMAP technology and flow cytometer. The mission we conduct is particularly demanding: continuous monitoring, multiple threat agents, high sensitivity, challenging environments, and ultimately extremely low false positive rates. Here, we introduce the mission requirements and metrics, show the system engineering and analysis framework, and describe the progress to date including early development and current status.

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PDF-file: 36 pages; size: 0.3 Mbytes

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Dzenitis, J M & Makarewicz, A J January 13, 2009.

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Description

We developed, tested, and now operate a civilian biological defense capability that continuously monitors the air for biological threat agents. The Autonomous Pathogen Detection System (APDS) collects, prepares, reads, analyzes, and reports results of multiplexed immunoassays and multiplexed PCR assays using Luminex{copyright} xMAP technology and flow cytometer. The mission we conduct is particularly demanding: continuous monitoring, multiple threat agents, high sensitivity, challenging environments, and ultimately extremely low false positive rates. Here, we introduce the mission requirements and metrics, show the system engineering and analysis framework, and describe the progress to date including early development and current status.

Physical Description

PDF-file: 36 pages; size: 0.3 Mbytes

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  • Journal Name: Chapter in Book: The Microflow Cytometer, N/A, N/A, January 1, 2010, pp. 263-286

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  • Report No.: LLNL-JRNL-410104
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 984930
  • Archival Resource Key: ark:/67531/metadc1013987

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • January 13, 2009

Added to The UNT Digital Library

  • Oct. 14, 2017, 8:36 a.m.

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  • Oct. 27, 2017, 5:32 p.m.

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Dzenitis, J M & Makarewicz, A J. The Autonomous Pathogen Detection System, article, January 13, 2009; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc1013987/: accessed December 16, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.