Neural assembly models derived through nano-scale measurements.

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Description

This report summarizes accomplishments of a three-year project focused on developing technical capabilities for measuring and modeling neuronal processes at the nanoscale. It was successfully demonstrated that nanoprobes could be engineered that were biocompatible, and could be biofunctionalized, that responded within the range of voltages typically associated with a neuronal action potential. Furthermore, the Xyce parallel circuit simulator was employed and models incorporated for simulating the ion channel and cable properties of neuronal membranes. The ultimate objective of the project had been to employ nanoprobes in vivo, with the nematode C elegans, and derive a simulation based on the resulting ... continued below

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29 p.

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Fan, Hongyou; Branda, Catherine; Schiek, Richard Louis; Warrender, Christina E. & Forsythe, James Chris September 1, 2009.

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Description

This report summarizes accomplishments of a three-year project focused on developing technical capabilities for measuring and modeling neuronal processes at the nanoscale. It was successfully demonstrated that nanoprobes could be engineered that were biocompatible, and could be biofunctionalized, that responded within the range of voltages typically associated with a neuronal action potential. Furthermore, the Xyce parallel circuit simulator was employed and models incorporated for simulating the ion channel and cable properties of neuronal membranes. The ultimate objective of the project had been to employ nanoprobes in vivo, with the nematode C elegans, and derive a simulation based on the resulting data. Techniques were developed allowing the nanoprobes to be injected into the nematode and the neuronal response recorded. To the authors's knowledge, this is the first occasion in which nanoparticles have been successfully employed as probes for recording neuronal response in an in vivo animal experimental protocol.

Physical Description

29 p.

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  • Report No.: SAND2009-6209
  • Grant Number: AC04-94AL85000
  • DOI: 10.2172/993899 | External Link
  • Office of Scientific & Technical Information Report Number: 993899
  • Archival Resource Key: ark:/67531/metadc1013244

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

  • September 1, 2009

Added to The UNT Digital Library

  • Oct. 14, 2017, 8:36 a.m.

Description Last Updated

  • Oct. 24, 2017, 2:38 p.m.

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Fan, Hongyou; Branda, Catherine; Schiek, Richard Louis; Warrender, Christina E. & Forsythe, James Chris. Neural assembly models derived through nano-scale measurements., report, September 1, 2009; United States. (digital.library.unt.edu/ark:/67531/metadc1013244/: accessed July 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.