Prediction of Toxicity, Sensory Responses and Biological Responses with the Abraham Model

Prediction of Toxicity, Sensory Responses and Biological Responses with the Abraham Model

Date: February 10, 2012
Creator: Acree, William E. (William Eugene); Grubbs, Laura M. & Abraham, M. H. (Michael H.)
Description: This book chapter discusses the prediction of toxicity, sensory responses and biological responses with the Abraham model.
Contributing Partner: UNT College of Arts and Sciences
Toxicity Studies of Aquatic Actinomycetes

Toxicity Studies of Aquatic Actinomycetes

Date: August 1952
Creator: Fair, Helena Juengermann
Description: Since Actinomycetes have been isolated from finished public drinking water, it is believed that the organisms are unaffected by the chlorination and flocculation of water treatment plants and pass as spores through the filters into the general distribution system. For this reason it was deemed imperative to study the toxic effects of these organisms.
Contributing Partner: UNT Libraries
Solvent Effects and Bioconcentration Patterns of Antimicrobial Compounds in Wetland Plants

Solvent Effects and Bioconcentration Patterns of Antimicrobial Compounds in Wetland Plants

Date: May 2011
Creator: Adhikari, Sajag
Description: This study looked at effects of organic solvents dimethylsulfoxide, dimethylformamide and acetone at 0.01%, 0.05% and 0.1% concentration on germination and seedling development wetland plants. Even at 0.01% level, all solvents affected some aspect of seed germination or seedling growth. Acetone at 0.01% was least toxic. Root morphological characteristics were most sensitive compared to shoot morphological characteristics. This study also looked at bioconcentration patterns of antimicrobial compounds triclosan, triclocarban and methyl-triclosan in wetland plants exposed to Denton Municipal Waste Water Treatment Plant effluent. Bioconcentration patterns of antimicrobial compounds varied among species within groups as well as within organs of species. The highest triclocarban, triclosan and methyltriclosan concentration were in shoot of N. guadalupensis, root of N. lutea and in shoots of P. nodous respectively.
Contributing Partner: UNT Libraries
Temporal and Spatial Comparisons of Ambient Toxicity of the Trinity River in Relationship to an Effluent

Temporal and Spatial Comparisons of Ambient Toxicity of the Trinity River in Relationship to an Effluent

Date: December 1993
Creator: Hall, David B., 1958-
Description: A toxicological study was initiated because of concerns about allegations that the Texas Water Commission that effluent from the Dallas Central Wastewater Treatment Plant, which discharges into the Trinity River, was affecting downstream water quality. Monthly, flow-weighted composite effluent samples were collected. Grab samples were also collected upstream and downstream from the effluent from April 1989 to August 1991. Toxicity tests were conducted on these samples using Ceriodaphnia dubia as the test organism. Samples were collected four times during this study in which rainfall occurred prior to sampling. In every instance, this "first flush" of the watershed during a rising hydrograph was toxic to C. dubia upstream. Analyzing toxicity by season resulted in a statistically significantly lower neonate production in the effluent than in the river samples during the months of June, July, and August. This impact on neonate production was suspected of being caused by organic pesticides which are used for insect control on lawns. The effluent was never acutely toxic to C. dubia. Primarily, toxic occurrences in either the effluent or the river samples were primarily of a chronic nature. Overall, survival of C. dubia was affected more frequently at the upstream site than in the effluent or ...
Contributing Partner: UNT Libraries
The Attempted Synthesis of some Heterocyclic Sulfones

The Attempted Synthesis of some Heterocyclic Sulfones

Date: 1949
Creator: Compton, William David
Description: This thesis describes two experiments: one related to antihistamines, and the other related to antitubercular compounds.
Contributing Partner: UNT Libraries
Toxicological Characterization of Trinity River Sediments

Toxicological Characterization of Trinity River Sediments

Date: December 1989
Creator: Hall, Jerry F. (Jerry Fowler)
Description: Sediments in the Trinity River were chemically, physically and biologically characterized and assessed for toxicity. Laboratory bioassays were conducted to identify sediments which induced toxic responses in test organisms and to document these responses through time. Metal and organic contaminant concentrations in bottom sediments were measured. Relationships between these concentrations and biological responses observed in laboratory bioassays were determined. Toxicity identification / reduction methods were used to characterize sediment toxicants. Sediment oxygen demand was also measured in resuspended and undisturbed bottom sediments through time. The Background Sediment Chemistry Approach and the Sediment Bioassay Approach were used to assess sediment quality. Sediment toxicity was observed in whole sediment bioassays using Chironomus tentans as the test species. A relationship between sediment contaminant concentration and toxicity was observed in approximately sixty percent of the sediments. Oxygen demand of resuspended sediments was elevated in sediments at two locations on the river. Oxygen demand of undisturbed sediments was elevated at one location on the river. Characterization of sediment toxicants was conducted using EDTA, pH, and carbon treatments and manipulations of the sediments. Aeration tests were also used to evaluate the contribution of volatile organic contaminants to observed toxicity.
Contributing Partner: UNT Libraries
Comparative Toxicity of Refuse-Derived Fuel Fly Ash on Two Species of Earthworms, Lumbricus terrestris and E. foetida, Using an Artificial Soil Exposure Protocol

Comparative Toxicity of Refuse-Derived Fuel Fly Ash on Two Species of Earthworms, Lumbricus terrestris and E. foetida, Using an Artificial Soil Exposure Protocol

Date: May 1991
Creator: Jahani, Aghamolla
Description: None
Contributing Partner: UNT Libraries
Structure-Activity Studies of Halopyrethroids

Structure-Activity Studies of Halopyrethroids

Date: December 1974
Creator: Brown, Dale Gordon
Description: None
Contributing Partner: UNT Libraries
Cytotoxicity and Functional Toxicity of Mefloquine and Search for Protective Compounds

Cytotoxicity and Functional Toxicity of Mefloquine and Search for Protective Compounds

Date: May 2015
Creator: Holmes, Katelyn
Description: Mefloquine hydrochloride is an antimalarial agent that has been used for the past 40 years. Numerous reports of neurological side effects have recently led the FDA to issue a strong warning regarding long-term neurological effects. This warning lead to the U.S. Army’s Special Forces and other components to discontinue its use in July of 2013. Despite reported adverse side effects, mefloquine remains in circulation and is recommended to travelers going to specific Asian countries. Mefloquine has been used as a treatment for those already infected with the malaria parasite (blood concentrations ranging from 2.1 to 23 µM), and as prophylaxis (blood concentrations averaging 3.8 µM) (Dow 2003). The purpose of this study was to quantify Mefloquine’s toxicity using spontaneously active nerve cell networks growing on microelectrode arrays in vitro and to identify compounds that alleviate or reduce toxic effects. The current literature on mefloquine toxicity is lacking electrophysiological data. These data will contribute to research on the mechanism of adverse side effects associated with mefloquine use. Sequential titration experiments were performed by adding increasing concentrations of mefloquine solution to cultured neurons. Network responses were quantified and reversibility was examined. In each network, activity decreases were normalized as a percent of ...
Contributing Partner: UNT Libraries
Environmental Contaminants in Food

Environmental Contaminants in Food

Date: December 1979
Creator: United States. Congress. Office of Technology Assessment.
Description: An assessment by the Office of Technology Assessment (OTA) that is "concerned with chemical and radioactive contaminants that inadvertently find their way into the human food supply" (p. iii).
Contributing Partner: UNT Libraries Government Documents Department
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