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Identification of Hox Genes Controlling Thrombopoiesis in Zebrafish

Description: Thrombocytes are functional equivalents of mammalian platelets and also possess megakaryocyte features. It has been shown earlier that hox genes play a role in megakaryocyte development. Our earlier microarray analysis showed five hox genes, hoxa10b, hoxb2a, hoxc5a, hoxc11b and hoxd3a, were upregulated in zebrafish thrombocytes. However, there is no comprehensive study of genome wide scan of all the hox genes playing a role in megakaryopoiesis. I first measured the expression levels of each of … more
Date: December 2015
Creator: Sundaramoorthi, Hemalatha
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Zebrafish Von Willebrand Factor

Description: In humans, von Willebrand factor (vWF) is a key component in hemostasis and acts as a 'cellular adhesive' by letting the circulating platelets bind to exposed subendothelium. It also acts as a carrier and stabilizer of factor VIII (FVIII). A dysfunction or reduction of vWF leads to von Willebrand disease (vWD), resulting in bleeding phenotype which affects 1% of the population. Currently there are a variety of animal models used for the study of vWF and vWD; however, they do not possess the … more
Date: August 2012
Creator: Carrillo, Maira M.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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