Description: This paper discusses research on the geography of cerebrovascular disease (CVD) in Texas. Abstract: This study examines the spatial distribution of CVD mortality rates in Texas counties from 1999-2003. The human ecology model is used to see how CVD relates with selected variables, specifically how CVD mortality rates relate to aquifer water hardness using the Mann-Whitney U test and independent samples t-test. The results show that counties with higher water hardness levels have lower CVD mortality rates. Results for race/ethnicity suggest that African Americans are more vulnerable to the disease, whereas Hispanic American CVD mortality rates were much lower. For further research, it would be of paramount importance to closely examine the actual water consumed in Texas counties to probe more rigorously the relationship between aquifer water hardness and CVD mortality.