Neuronal Network Analyses in vitro of Acute Individual and Combined Responses to Fluoxetine and Ethanol

Neuronal Network Analyses in vitro of Acute Individual and Combined Responses to Fluoxetine and Ethanol

Date: August 2002
Creator: Xia,Yun
Description: Embryonic murine neuronal networks cultured on microelectrode arrays were used to quantify acute electrophysiological effects of fluoxetine and ethanol. Spontaneously active frontal cortex cultures showed highly repeatable, dose-dependent sensitivities to both compounds. Cultures began to respond to fluoxetine at 3 µM and were shut off at 10-16 µM. EC50s mean ± S.D. for spike and burst rates were 4.1 ± 1.5 µM and 4.5 ± 1.1 µM (n=14). The fluoxetine inhibition was reversible and without effect on action potential wave shapes. Ethanol showed initial inhibition at 20 mM, with spike and burst rate EC50s at 52.0 ± 17.4 mM and 56.0 ± 17.0 mM (n=15). Ethanol concentrations above 100 -140 mM led to cessation of activity. Although ethanol did not change the shape and amplitude of action potentials, unit specific effects were found. The combined application of ethanol and fluoxetine was additive. Ethanol did not potentiate the effect of fluoxetine.
Contributing Partner: UNT Libraries
Neural Dynamics: Criticality, Cooperation, Avalanches and Entrainment between Complex Networks

Neural Dynamics: Criticality, Cooperation, Avalanches and Entrainment between Complex Networks

Date: May 22, 2012
Creator: Grigolini, Paolo; Zare, Marzieh; Svenkeson, Adam & West, Bruce J.
Description: Book chapter discussing neural dynamics and the criticality, cooperation, avalanches and entrainment between complex networks.
Contributing Partner: UNT College of Arts and Sciences
Networking of psychophysics, psychology, and neurophysiology

Networking of psychophysics, psychology, and neurophysiology

Date: November 5, 2012
Creator: West, Bruce J. & Grigolini, Paolo
Description: Article discussing the dynamic networking and dynamic networks in complex research on psychophysics, psychology, and neurophysiology.
Contributing Partner: UNT College of Arts and Sciences
The Dynamics of EEG Entropy

The Dynamics of EEG Entropy

Date: March 5, 2009
Creator: Ignaccolo, Massimiliano; Latka, Miroslaw; Jernajczyk, Wojciech; Grigolini, Paolo & West, Bruce J.
Description: This article discusses the dynamics of EEG entropy.
Contributing Partner: UNT College of Arts and Sciences
Characterizing Spontaneous Neurophysiological Activity with Measures of Statistical Serial Dependence: a Summary Statistic and an Extension of the Joint Interval Histogram

Characterizing Spontaneous Neurophysiological Activity with Measures of Statistical Serial Dependence: a Summary Statistic and an Extension of the Joint Interval Histogram

Date: August 1994
Creator: Weil, Jon C. (Jon Christopher)
Description: Two measures which indicate statistical serial dependence were evaluated. The n-dimensional Average Stored Information index (ndASI) is a measure of conditional information, which compares the entropies of higher order conditional distributions to estimate average statistical serial dependence. The generalized ranked joint interval histogram (RJIH-o) is a new nonparametric graphical analysis method. It extends the joint interval histogram by depicting longer interval sequences and can be interpereted precisely analagously to the joint interval histogram. The generalized ranked joint interval histogram correctly represents independence in a Poisson process model and statistical serial dependence in a directionally reinforced Markov model. The generalized ranked joint interval histogram correctly depicts the underlying periodic and strange attractors in a standard map model. Both measures can be used to effectively analyze interspike interval sequences from spontaneous neurophsyiological activity effectively.
Contributing Partner: UNT Libraries