Synthesis and Characterization of Copper Releasing Polymer Nanoparticles

Synthesis and Characterization of Copper Releasing Polymer Nanoparticles

Date: May 2011
Creator: Harris, Alesha N.
Description: Polymeric nanoparticles were synthesized and loaded with Cu²⁺ to explore the therapeutic potential for catically active transition metal ions and complexes other than cisplatin. Two types of nanoparticles were synthesized to show the potential for polymer based vectors. Copper loading and release were characterized via inductively coupled plasma mass spectrometry (ICP MS), energy dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), and elemental analysis. Results demonstrated that Cu could be loaded to the nano-sized carriers in an aqueous environment, and that the release was pH-dependent. The toxicity of these particles was measured in HeLa cells where significant toxicity was observed in vitro via dosing of high Cu-loaded nanoparticles. No significant toxicity was observed in cells dosed with Cu-free nanoparticles.
Contributing Partner: UNT Libraries
Hydrogen Adsorption on Platinum-Gold Bimetallic Nanoparticles: A Density Functional Theory Study

Hydrogen Adsorption on Platinum-Gold Bimetallic Nanoparticles: A Density Functional Theory Study

Date: June 24, 2013
Creator: Hu, Minmin; Linder, Douglas P.; Buongiorno Nardelli, Marco & Striolo, Alberto
Description: Article on hydrogen adsorption on platinum-gold bimetallic nanoparticles.
Contributing Partner: UNT College of Arts and Sciences
Biocompatible Hybrid Nanomaterials Involving Polymers and Hydrogels Interfaced with Phosphorescent Complexes and Toxin-Free Metallic Nanoparticles for Biomedical Applications

Biocompatible Hybrid Nanomaterials Involving Polymers and Hydrogels Interfaced with Phosphorescent Complexes and Toxin-Free Metallic Nanoparticles for Biomedical Applications

Date: August 2011
Creator: Marpu, Sreekar B.
Description: The major topics discussed are all relevant to interfacing brightly phosphorescent and non-luminescent coinage metal complexes of [Ag(I) and Au(I)] with biopolymers and thermoresponsive gels for making hybrid nanomaterials with an explanation on syntheses, characterization and their significance in biomedical fields. Experimental results and ongoing work on determining outreaching consequences of these hybrid nanomaterials for various biomedical applications like cancer therapy, bio-imaging and antibacterial abilities are described. In vitro and in vivo studies have been performed on majority of the discussed hybrid nanomaterials and determined that the cytotoxicity or antibacterial activity are comparatively superior when compared to analogues in literature. Consequential differences are noticed in photoluminescence enhancement from hybrid phosphorescent hydrogels, phosphorescent complex ability to physically crosslink, Au(I) sulfides tendency to form NIR (near-infrared) absorbing AuNPs compared to any similar work in literature. Syntheses of these hybrid nanomaterials has been thoroughly investigated and it is determined that either metallic nanoparticles syntheses or syntheses of phosphorescent hydrogels can be carried in single step without involving any hazardous reducing agents or crosslinkers or stabilizers that are commonly employed during multiple step syntheses protocols for syntheses of similar materials in literature. These astounding results that have been discovered within studies of hybrid nanomaterials ...
Contributing Partner: UNT Libraries
Nanoparticle-assisted microwave absorption by single-wall carbon nanotubes

Nanoparticle-assisted microwave absorption by single-wall carbon nanotubes

Date: September 29, 2003
Creator: Wadhawan, Atul; Garrett, David & Pérez, José M.
Description: This article discusses nanoparticle-assisted microwave absorption by single-wall carbon nanotubes.
Contributing Partner: UNT College of Arts and Sciences
Synthesis, Uses and Compositions of Crystal Hydrogels

Synthesis, Uses and Compositions of Crystal Hydrogels

Date: November 15, 2002
Creator: Hu, Zhibing; Lu, Xihua; Gao, Jun; Cai, Tong; Huang, Gang & Zhou, Bo
Description: Patent relating to the synthesis, uses and compositions of crystal hydrogels.
Contributing Partner: UNT College of Arts and Sciences
Escherichia Coli CSRB Gene and RNA Encoded Thereby

Escherichia Coli CSRB Gene and RNA Encoded Thereby

Date: November 15, 2002
Creator: Hu, Zhibing; Lu, Xihua; Gao, Jun; Cai, Tong; Huang, Gang & Zhou, Bo
Description: Patent regarding the synthesis, uses and compositions of crystal hydrogels.
Contributing Partner: UNT College of Arts and Sciences
Phototoxic Effects of Titanium Dioxide Nanoparticles on Daphnia Magna

Phototoxic Effects of Titanium Dioxide Nanoparticles on Daphnia Magna

Date: December 2013
Creator: Mansfield, Charles M.
Description: Titanium dioxide nanoparticles (TiO2-NP) are one of the most abundantly utilized nanomaterials in the world. Studies have demonstrated the mechanism of acute toxicity in TiO2-NP to be the production of reactive oxygen species (ROS) leading to oxidative stress and mortality in exposed organisms. It has also been demonstrated that the anatase crystalline conformation is capable of catalyzing the cleavage of water molecules to further increase the concentration of ROS in the presence of ultraviolet radiation. This photoenhanced toxicity significantly lowers the toxicity threshold of TiO2-NP to environmentally relevant concentrations (ppb). The goal of this study was to determine whether dietary uptake and accumulation of TiO2-NP in the aquatic filter feeder Daphnia magna resulted in photoenhanced toxicity. D. magna and S. caprincornatum were exposed to aqueous solutions of 20ppm and 200ppm TiO2-NP for 24hrs and then transferred to clean moderately hard water. Samples were taken at various time points, dried, and TiO2 quantified using ICP-MS. Toxicity assays were run on D. magna using three TiO2-NP (20ppm, 200ppm) exposure protocols and two ultraviolet radiation treatments. The first exposure group was exposed to aqueous solutions of TiO2-NP for the duration of the test. The second exposure group was exposed to TiO2-NP for an ...
Contributing Partner: UNT Libraries