Synthesis and Study of Glutaryl-S-(ω-aminoalkyl)-L-cysteinylglycines as Inhibitors of Glyoxalase I
Description:
This thesis describes the synthesis and preliminary enzymatic study of glutaryl-S-(8-aminooctyl)-L-cysteinylglycine and glutaryl-S-(10-aminodecyl)-L-cysteinylglycine as inhibitors of glyoxalase I. These analogs of glutathione were prepared as potential ligands for affinity chromatography purification of glyoxalase I. The compounds were synthesized by a seven-step procedure in overall yields of 24% for the octyl analog and 33% for the decyl analog. Both compounds exhibited mixed type inhibition …
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Date:
May 1975
Creator:
Phillips, Gerald Wayne
Partner:
UNT Libraries