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Regulation of Colony-Stimulating Factor-1 Biosynthesis

Description: Recent studies suggest that synthesis of the Colony-stimulating factor (CSF) is a well regulated process. However, the molecular mechanisms of the signal transduction of the various inducers of CSF such as monokines and lymphokines are not well understood. Using Interleukin 1 (IL-1) stimulation of CSF-1 in the MIA PaCa-2 cell line as a model system, the involvement of G-protein has been studied. The IL-1 induction of CSF-1 synthesis can be inhibited by both Pertussis toxin and Cholera toxin, wh… more
Date: May 1990
Creator: Ku, Chun-Ying
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Genomic and Co-expression Analyses Predict Multiple Genes Involved in Triterpene Saponin Biosynthesis in Medicago truncatula

Description: Article discusses genomic and coexpression analyses predicting multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula.
Date: March 9, 2010
Creator: Naoumkina, Marina A.; Modolo, Luzia V.; Huhman, David; Urbanczyk-Wochniak, Ewa; Tang, Yuhong; Sumner, Lloyd W. et al.
Item Type: Refine your search to only Article
Partner: UNT College of Arts and Sciences
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Isolation and Partial Characterization of Pigment Mutants of Corynebacterium poinsettie ATCC 9682

Description: Carotenoid pigments were extracted from Corynebacteriuma poinsettiae (wild type) ATCC 9682, and from 108 mutants obtained by exposure of a streptomycin resistant strain of C. poinsettiae to ultra-violet light irradiation and N-methyl- N'-nitro-N-nitrosoguanidine. The pigments were characterized by their absorption maxima, Rf-values, and partition ratios in petroleum ether and methanol. Thin layer chromatography was used to compare pigments of the wild type with those of the mutants. Possible bi… more
Date: August 1980
Creator: Wariso, Benjamin A.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Studies on Carotenoid Biosynthesis and Carotenoproteins of Corynebacterium Poinsettiae ATCC 9682

Description: Thin layer chromatography and high performance liquid chromatography were used to compare pigments of the wild type streptomycin resistant strain of C. poinsettiae with those of mutants derived from it. Possible biosynthetic pathways in carotenoid biosynthesis of the wild type were postulated on the basis of observed blocks in pigment synthesis.
Date: August 1983
Creator: Wariso, Benjamin A.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Genetic Mutations in the S-loop of Human Glutathione Synthetase: Links Between Substrate Binding, Active Site Structure and Allostery

Description: This article uses molecular dynamics simulations and experimental point mutations to probe the role of S-loop residues in tertiary structure, substrate binding, and allosteric communication.
Date: November 29, 2018
Creator: Ingle, Brandall L.; Shrestha, Bibesh; De Jesus, Margarita C.; Conrad-Webb, Heather M.; Anderson, Mary E. & Cundari, Thomas R., 1964-
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans

Description: This article investigates the role of the highly conserved α,β-hydrolase enzymes PyiE and ORFZ during the biosynthesis of pyrichalasin H and the ACE1 metabolite, respectively, using gene knockout and complementation techniques. Taken together the results suggest that the α,β-hydrolase enzymes are essential for first ring cyclisation, but the precise nature of the intermediates remains to be determined.
Date: November 4, 2020
Creator: Zhang, Haili; Hantke, Verena; Bruhnke, Pia; Skellam, Elizabeth & Cox, Russell J.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Investigations of the Alkaloid Content of Nicotiana Species and Interspecific Combinations

Description: Alkaloid content was analyzed by paper-partition chromatography in the following Nicotianas: (1) 52 species representing all taxonomic sections and centers of geographical distribution. (2) 35 two-species combinations including one species of hybrid origin, 5 F₁ interspecific hybrids, 24 amphiploids and 5 sesquiploids. (3) 14 three-species combinations including 6 hybrids between an amphiploid and a third species and 4 different three-species combinations with doubled chromosome number. (4) 2 f… more
Date: 1962
Creator: Smith, Harold H. & Abashian, Dorothy V.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Substrate Specificity of LACCASE8 Facilitates Polymerization of Caffeyl Alcohol for C-Lignin Biosynthesis in the Seed Coat of Cleome hassleriana

Description: This article finds that the transcript profile of the laccase gene ChLAC8 parallels the accumulation of C-lignin during seed coat development. Recombinant ChLAC8 oxidizes caffeyl and sinapyl alcohols, generating their corresponding dimers or trimers in vitro, but cannot oxidize coniferyl alcohol. The authors propose a basis for this substrate preference based on molecular modeling/docking experiments. Suppression of ChLAC8 expression led to significantly reduced C-lignin content in the seed coa… more
Date: October 9, 2020
Creator: Wang, Xin; Zhuo, Chunliu; Xiao, Xirong; Wang, Xiaoqiang; Docampo-Palacios, Maite; Chen, Fang et al.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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VvLAR1 and VvLAR2 Are Bifunctional Enzymes for Proanthocyanidin Biosynthesis in Grapevine

Description: This article shows that both Cys-EC and 4β-(S-cysteinyl)-catechin (Cys-C) are present in grapevine. The data from this study advance knowledge of PA building blocks and LAR function and provide targets for grapevine breeding to alter PA composition.
Date: May 15, 2019
Creator: Dixon, R. A.; Jun, Ji Hyung; Yu, Keji & Duan, Changqing
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Developmental changes in lignin composition are driven by both monolignol supply and laccase specificity

Description: Article proposes a model in which, during C-lignin biosynthesis, caffeyl alcohol noncompetitively inhibits oxidation of coniferyl alcohol by cell wall laccases, a process that might limit movement of coniferyl alcohol to the apoplast.
Date: March 9, 2022
Creator: Zhou, Chunliu; Wang, Xin; Docampo-Palacios, Maite; Sanders, Brian C.; Engle, Nancy L.; Tschaplinski, Timothy J. et al.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Stereochemical and Biosynthetic Rationalisation of the Tropolone Sesquiterpenoids

Description: Article summarises the known structures, biological activities, and biosynthetic pathways of the tropolone sesquiterpenoid family of fungal secondary metabolites. Synthesis of this knowledge allows likely structural and stereochemical misassignments to be revised and shows how the compounds can be divided into three main biosynthetic classes based on the stereochemistry of key biosynthetic steps.
Date: August 31, 2022
Creator: Li, Lei & Cox, Russell, J.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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The protein conformational basis of isoflavone biosynthesis

Description: Authors of the article assert that isoflavonoids play important roles in plant defense and also exhibit a range of mammalian health-promoting activities. They emphasize that understanding the structural basis of isoflavone biosynthesis will facilitate the engineering of new bioactive isoflavonoids.
Date: November 15, 2022
Creator: Wang, Xiaoqiang; Pan, Haiyun; Sagurthi, Someswar; Paris, Vincent; Zhuo, Chunliu & Dixon, R. A.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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