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Developmental Effects of a Non-Dioxin-Like Polychlorinated Biphenyl Mixture on Zebrafish (Danio rerio)

Description: PCBs are synthetic organic compounds known for their toxicity to many organisms and are notorious for having large discrepancies between measured and nominal concentrations. Historically thought to be less toxic, non-dioxin-like (NDL) PCBs represent the majority of congeners and are capable of eliciting neurotoxic effects. NDL-PCBs remain understudied, including their effects on aquatic organisms. In the first study, I collected extensive chemistry data and data on neurobehavioral and cardiac e… more
This item is restricted from view until August 1, 2024.
Date: July 2023
Creator: Green, Corey
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries

Role of MicroRNAs and Their Downstream Targets in Zebrafish Thrombopoiesis

Description: Previous studies have shown that human platelets and megakaryocytes carry microRNAs suggesting their role in platelet function and megakaryocyte development, respectively. However, there is limited information on microRNAs' role in zebrafish thrombopoiesis. Zebrafish thrombocytes could be used as a model to study their role in megakaryocyte maturation and platelet function because thrombocytes have both megakaryocyte features and platelet properties. In our laboratory, I identified 15 microRNAs… more
This item is restricted from view until June 1, 2025.
Date: May 2023
Creator: Al Qaryoute, Ayah
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Trypsin induces an aversive response in zebrafish by PAR2 activation in keratinocytes

Description: Article using zebrafish as a model and identifies that trypsin induces an aversive response in zebrafish larvae and adult zebrafish. Results show that the trypsin activates PAR2 on keratinocytes signaling the brain, and this pathway of trypsin-induced escape response will provide a unique communication mechanism in zebrafish.
Date: October 8, 2021
Creator: Alsrhani, Abdullah; Raman, Revathi & Jagadeeswaran, Pudur
Item Type: Refine your search to only Article
Partner: UNT College of Science

Studies on Intrinsic Coagulation Pathway of Zebrafish

Description: In the past couple of decades, the zebrafish has been widely used to study hemostatic disorders. In this study, we generated a CRISPR/Cas9 mediated zebrafish mutant that contains a 55-nucleotide insertion in exon 29 of the von Willebrand factor (vwf) gene. The mutants had impaired ristocetin-mediated agglutination of whole blood, prolonged PTT and more bleeding in the lateral incision compared to wild-type fish. The bleeding phenotype observed here is similar to the phenotype observed in vwf kn… more
Date: August 2021
Creator: Iyer, Neha
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries

Studies on the Fibrinolytic Pathway in Zebrafish

Description: Fibrinolysis pathway is an important mechanism for dissolution of fibrin clot by the action of plasmin which is formed from plasminogen, a zymogen via the action of plasminogen activators, i.e. tissue plasminogen activator and urinary plasminogen activator. The regulation of fibrinolysis system in vivo is maintained by plasminogen activators and natural inhibitors i.e. α2-antiplasmin, α2-macroglobulin, Thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen activator inhibitor 1 and … more
Date: August 2021
Creator: Gill, Jaspreet Kaur
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Antimicrobial and Anti-Platelet Activity in Botanical Extracts of Plants Collected in Northern Thailand

Description: The purpose of my research work was to assess a variety of Northern Thailand plants tissue extracts for antibacterial and anti-platelet aggregation activity. The Minimum Inhibitory Concentration assay method was used to assess antimicrobial activity of plant extracts, while the Zebrafish Platelet Aggregation Assay and the in vitro Whole Human Blood Impedance Aggregation Assay were used to study anti-platelet activity. Forty one plant extracts harvested from the tissues of 26 plants collected fr… more
Date: May 2019
Creator: Patcharapinyopong, Thanasan
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Studies in Trypsin as an Alarm Substance in Zebrafish

Description: Previous studies have shown that fish release alarming substances into the water to alert their kin to escape from danger. In our laboratory, we found that zebrafish produce trypsin and release it from their gills into the environment when they are under stress. By placing the zebrafish larvae in the middle of a small tank and then placing trypsin at one end of the tank, we observed that the larvae moved away from the trypsin zone and almost to the opposite end of the tank. This escape response… more
Date: August 2018
Creator: Alsrhani, Abdullah Falleh
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Studies on Zebrafish Thrombocyte Function

Description: Thrombocytes are important players in hemostasis. There is still much to be explored regarding the molecular basis of the thrombocyte function. In our previous microarray analysis data, we found IFT122 (an intraflagellar transport protein known to be involved in cilia formation) transcripts in zebrafish thrombocytes. Given recent discoveries of non-ciliary roles for IFTs, we examined the possibility that IFT122 affects thrombocyte function. We studied the role of IFT122 in thrombocyte function.… more
Date: May 2017
Creator: Pulipakkam Radhakrishnan, Uvaraj
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Zebrafish Von Willebrand Factor

Description: In humans, von Willebrand factor (vWF) is a key component in hemostasis and acts as a 'cellular adhesive' by letting the circulating platelets bind to exposed subendothelium. It also acts as a carrier and stabilizer of factor VIII (FVIII). A dysfunction or reduction of vWF leads to von Willebrand disease (vWD), resulting in bleeding phenotype which affects 1% of the population. Currently there are a variety of animal models used for the study of vWF and vWD; however, they do not possess the … more
Date: August 2012
Creator: Carrillo, Maira M.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Influence of parental swimming stamina on the cardiac and metabolic performance of larval zebrafish (Danio rerio).

Description: Superior swimming stamina in adult fish is presumably passed on to their offspring, but the ontogeny of the appearance of superior stamina and the requisite enhanced cardio-respiratory support for locomotion in larval fishes has not been determined. Is the expression of the suite of parental traits enabling superior swimming stamina in their offspring dependent upon their achieving juvenile/adult morphology, or does it appear earlier in their larvae? To answer this, adults were classified int… more
Date: May 2007
Creator: Gore, Matthew R.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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