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Epipod : Community Vaccination and Dispensing Model User's Guide.

EpiPOD is a modeling system that enables local, regional, and county health departments to evaluate and refine their plans for mass distribution of antiviral and antibiotic medications and vaccines. An intuitive interface requires users to input as few or as many plan specifics as are available in order to simulate a mass treatment campaign. Behind the input interface, a system dynamics model simulates pharmaceutical supply logistics, hospital and first-responder personnel treatment, population… more

Date: January 9, 2009

Creator: Berry, M.; Samsa, M.; Walsh, D. & Sciences, Decision and Information

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

HIV-1 intrapatient sequence diversity in the immunogenic V3 region

The third hypervariable domain (V3) of the human immunodeficiency virus type-1 (HIV-1) envelope protein (env) can serve as an epitope for potent type-specific neutralizing antibodies (NAbs) -- thus short peptides predicted on the most commonly found variants of the antigenic tip of the V3 loop have been considered as potential candidates for an HIV peptide vaccine. To evaluate the extent of intrapatient variation in the immunogenic crest of the V3 loop, sequence sets were analyzed from individu… more

Date: November 12, 1991

Creator: Korber, B.; Myers, G. (Los Alamos National Lab., NM (United States)); Wolinsky, S.; Kunstman, K.; Levy, R.; Furtado, M. et al.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Analyses of inter- and intra-patient variation in the V3 loop of the HIV-1 envelope protein

The third hypervariable domain of the HIV-1 gp120 envelope protein (V3) has been the focus of intensive sequencing efforts. To date, nearly one thousand V3 loop sequences have been stored in the HIV sequence database. Studies have revealed that the V3 loop elicits potent type-specific immune responses, and that it plays a significant role in cell tropism and fusion . The immunogenic tip of the loop can serve as a type-specific neutralizing antibody epitope, as well as a cytotoxic T-cell epitope… more

Date: September 17, 1991

Creator: Korber, B.; Myers, G. & Wolinsky, S.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Biological response modifiers

Much of what used to be called immunotherapy is now included in the term biological response modifiers. Biological response modifiers (BRMs) are defined as those agents or approaches that modify the relationship between the tumor and host by modifying the host's biological response to tumor cells with resultant therapeutic effects.'' Most of the early work with BRMs centered around observations of spontaneous tumor regression and the association of tumor regression with concurrent bacterial inf… more

Date: October 1, 1991

Creator: Weller, R. E.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Rapid microbial identification by circular intensity differential scattering

Circular Intensity Differential Scattering (CIDS) is one of the few really new approaches to microbial identification to have come into existence in the past several decades. The CIDS spectra can be measured as a function of wavelength, scattering angle, and/or matrix element, and a number of matrix elements can be measured virtually simultaneously. This panoply of measurements potentially gives the method resolving power for microbial identification. Some representative data taken over the pas… more

Date: June 1, 1984

Creator: Gregg, C.T. & Salzman, G.C.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Analyses of inter- and intra-patient variation in the V3 loop of the HIV-1 envelope protein

Date: September 17, 1991

Creator: Korber, Bette; Myers, Gerald & Wolinsky, Steven

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Final Report for LDRD Project 02-ERD-069: Discovering the Unknown Mechanism(s) of Virulence in a BW, Class A Select Agent

The goal of this proposed effort was to assess the difficulty in identifying and characterizing virulence candidate genes in an organism for which very limited data exists. This was accomplished by first addressing the finishing phase of draft-sequenced F. tularensis genomes and conducting comparative analyses to determine the coding potential of each genome; to discover the differences in genome structure and content, and to identify potential genes whose products may be involved in the F. tul… more

Date: February 6, 2003

Creator: Chain, P & Garcia, E

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

adendum for )6 report

Prior to using human nasopharyngeal samples, we will use prepared mixtures of viruses with bacteria and eukaryotic cells in our research on microfluidic separation techniques. Some examples of these mixtures are the bacteriophage MS2 with its host bacteria, E. coli, and BSL-1, Risk-Group-1 virus such as fowlpox virus vaccine with its host cell, DF-1, derived from chickens.

Date: February 2, 2007

Creator: Mariella, R.; Borucki, M.; Miles, R.; Claugue, D.; Dougherty, G. & Fisher, K.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Vaccine refrigerator testing. Final report

For the Central American Health Clinic Project initiated in 1986, Sandia National Laboratories and the Florida Solar Energy Center recognized the need for a test and evaluation program for vaccine refrigeration systems. At the Florida Solar Energy Center, side-by-side testing of three photovoltaic powered vaccine refrigerators began in 1987. The testing was expanded in 1988 to include a kerosene absorption refrigerator. This report presents observations, conclusions, and recommendations derived… more

Date: June 1, 1990

Creator: Ventre, G. G.; Kilfoyle, D. & Marion, B.

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Killing of targets by effector CD8 T cells in the mouse spleen follows the law of mass action

In contrast with antibody-based vaccines, it has been difficult to measure the efficacy of T cell-based vaccines and to correlate the efficacy of CD8 T cell responses with protection again viral infections. In part, this difficulty is due to poor understanding of the in vivo efficacy of CD8 T cells produced by vaccination. Using a: recently developed experimental method of in vivo cytotoxicity we have investigated quantitative aspects of killing of peptide-pulsed targets by effector and memory … more

Date: January 1, 2009

Creator: Ganusov, Vitaly V

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Expanded breadth of the T-cell response to mosaic HIV-1 envelope DNA vaccination

An effective AIDS vaccine must control highly diverse circulating strains of HIV-1. Among HIV -I gene products, the envelope (Env) protein contains variable as well as conserved regions. In this report, an informatic approach to the design of T-cell vaccines directed to HIV -I Env M group global sequences was tested. Synthetic Env antigens were designed to express mosaics that maximize the inclusion of common potential Tcell epitope (PTE) 9-mers and minimize the inclusion of rare epitopes likel… more

Date: January 1, 2009

Creator: Korber, Bette; Fischer, William & Wallstrom, Timothy

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Research on Captive Broodstock Programs for Pacific Salmon, 2001-2002 Annual Report.

The efficacy of captive broodstock programs depends on high in-culture survival and the fitness of cultured salmon after release, either as adults or juveniles. Continuing captive broodstock research designed to improve technology is being conducted to cover all major life history stages of Pacific salmon. The following summarizes some of the work performed and results from the FY 2001 performance period: (1) The incidence of male maturation of age-1 chinook salmon was significantly reduced by … more

Date: August 1, 2002

Creator: Berejikian, Barry; Tezak, E. & Endicott, Rick

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Low dose rectal inoculation of rhesus macaques by SIV smE660 or SIVmac251 recapitulates

We recently developed a novel strategy to identify transmitted HIV-1 genomes in acutely infected humans using single-genome amplification and a model of random virus evolution. Here, we used this approach to determine the molecular features of simian immunodeficiency virus (SIV) transmission in 18 experimentally infected Indian rhesus macaques. Animals were inoculated intrarectally (i.r.) or intravenously (i.v.) with stocks of SIVmac251 or SIVsmE660 that exhibited sequence diversity typical of … more

Date: January 1, 2008

Creator: Hraber, Peter; Giorgi, Elena E; Keele, Brandon; Li, Hui & Learn, Gerald

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Evolving T-cell vaccine strategies for HIV, the virus with a thousand faces

HIV's rapid global spread and the human suffering it has left in its wake have made AIDS a global heath priority for the 25 years since its discovery. Yet its capacity to rapidly evolve has made combating this virus a tremendous challenge. The obstacles to creating an effective HIV vaccine are formidable, but there are advances in the field on many fronts, in terms of novel vectors, adjuvants, and antigen design strategies. SIV live attenuated vaccine models are able to confer protection agains… more

Date: January 1, 2009

Creator: Korber, Bette

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Research on Captive Broodstock Programs for Pacific Salmon; Assessment of Captive Broodstock Technologies, Annual Report 2002-2003.

The success of captive broodstock programs depends on high in-culture survival, appropriate development of the reproductive system, and the behavior and survival of cultured salmon after release, either as adults or juveniles. Continuing captive broodstock research designed to improve technology is being conducted to cover all major life history stages of Pacific salmon. Current velocity in rearing vessels had little if any effect on reproductive behavior of captively reared steelhead. However,… more

Date: January 1, 2004

Creator: Berejikian, Barry

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

The race between infection and immunity - how do pathogens set the pace?

Infection is often referred to as a race between pathogen and immune response. This metaphor suggests that slower growing pathogens should be more easily controlled. However, a growing body ofevidence shows that many chronic infections are caused by failure to control slow growing pathogens. The slow growth of pathogens appears to directly affect the kinetics of the immune response. Compared with the response to fast growing pathogens, the T cell response to slow pathogens is delayed in its ini… more

Date: January 1, 2009

Creator: Ribiero, Ruy M

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Science and engineering of large scale socio-technical simulations.

Computer simulation is a computational approach whereby global system properties are produced as dynamics by direct computation of interactions among representations of local system elements. A mathematical theory of simulation consists of an account of the formal properties of sequential evaluation and composition of interdependent local mappings. When certain local mappings and their interdependencies can be related to particular real world objects and interdependencies, it is common to compu… more

Date: January 1, 2001

Creator: Barrett, C. L. (Christopher L.); Eubank, S. G. (Stephen G.); Marathe, M. V. (Madhav V.); Mortveit, H. S. (Henning S.) & Reidys, C. M. (Christian M.)

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Science and Technology Challenges for Homeland Security

Preventing and protecting against catastrophic terrorism is a complex and dynamic challenge. Small groups or individuals can use advanced technology to cause massive destruction, and the rapid pace of technology and ease of information dissemination continually gives terrorists new tools. A 100% defense is not possible. It's a numbers problem--there are simply too many possible targets to protect and too many potential attack scenarios and adversaries to defend against. However, science and tec… more

Date: March 24, 2006

Creator: Murray, C A

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Regulation of Yersina pestis Virulence by AI-2 Mediated Quorum Sensing

The proposed research was motivated by an interest in understanding Y. pestis virulence mechanisms and bacteria cell-cell communication. It is expected that a greater understanding of virulence mechanisms will ultimately lead to biothreat countermeasures and novel therapeutics. Y. pestis is the etiological agent of plague, the most devastating disease in human history. Y. pestis infection has a high mortality rate and a short incubation before mortality. There is no widely available and effecti… more

Date: March 29, 2010

Creator: Segelke, B; Hok, S; Lao, V; Corzett, M & Garcia, E

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Science and Technology Review July/August 2010

This issue has the following articles: (1) Deterrence with a Minimum Nuclear Stockpile - Commentary by Bruce T. Goodwin; (2) Enhancing Confidence in the Nation's Nuclear Stockpile - Livermore experts are participating in a national effort aimed at predicting how nuclear weapon materials and systems will likely change over time; (3) Narrowing Uncertainties - For climate modeling and many other fields, understanding uncertainty, or margin of error, is critical; (4) Insight into a Deadly Disease -… more

Date: May 27, 2010

Creator: Blobaum, K M

Item Type: Report

Partner: UNT Libraries Government Documents Department

open access

Energy Systems and Population Health

It is well-documented that energy and energy systems have a central role in social and economic development and human welfare at all scales, from household and community to regional and national (41). Among its various welfare effects, energy is closely linked with people s health. Some of the effects of energy on health and welfare are direct. With abundant energy, more food or more frequent meals can be prepared; food can be refrigerated, increasing the types of food items that are consumed a… more

Date: April 12, 2004

Creator: Ezzati, Majid; Bailis, Rob; Kammen, Daniel M.; Holloway, Tracey; Price, Lynn; Cifuentes, Luis A. et al.

Item Type: Article

Partner: UNT Libraries Government Documents Department

open access

Advanced Algorithms for Rapidly Reconstructing Clandestine Releases of Biological Agents in Urban Areas

As the United States plays a greater role in the 21st Century as global peacekeeper and international defender of human rights and democratic principles, there is an increasing likelihood that it will become the focus of acts of terrorism. Such acts of terrorism--sometimes described as ''asymmetric''--could involve the threat or use of weapons of mass destruction (WMD), particularly those considered unconventional, which include ones designed to release chemical or biological agents. In fact, b… more

Date: February 25, 2000

Creator: Shinn, J. H.; Hall, C. H.; Neher, L. A.; Wilder, F. J.; Gouveia, D. W.; Layton, D. W. et al.

Item Type: Report

Partner: UNT Libraries Government Documents Department

captions transcript

[News Clip: Briscoe]

Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.

Date: May 26, 1983, 6:00 p.m.

Duration: 36 seconds

Creator: KXAS-TV (Television station : Fort Worth, Tex.)

Item Type: Video

Partner: UNT Libraries Special Collections

open access

HIV-1 intrapatient sequence diversity in the immunogenic V3 region

Date: November 12, 1991

Creator: Korber, B.; Myers, G.; Wolinsky, S.; Kunstman, K.; Levy, R.; Furtado, M. et al.

Item Type: Article

Partner: UNT Libraries Government Documents Department