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Image-Based Modeling Reveals Dynamic Redistribution of DNA Damageinto Nuclear Sub-Domains

Description: Several proteins involved in the response to DNA doublestrand breaks (DSB) f orm microscopically visible nuclear domains, orfoci, after exposure to ionizing radiation. Radiation-induced foci (RIF)are believed to be located where DNA damage occurs. To test thisassumption, we analyzed the spatial distribution of 53BP1, phosphorylatedATM, and gammaH2AX RIF in cells irradiated with high linear energytransfer (LET) radiation and low LET. Since energy is randomly depositedalong high-LET particle path… more
Date: August 3, 2007
Creator: Costes Sylvain V.; Ponomarev, Artem; Chen, James L.; Nguyen, David; Cucinotta, Francis A. & Barcellos-Hoff, Mary Helen
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Partner: UNT Libraries Government Documents Department
open access

Relative Biological Effectiveness of HZE Fe Ions for Induction of Micro-Nuclei at Low Doses

Description: Dose-response curves for induction of micro-nuclei (MN) was measured in Chinese hamster V79 and xrs6 (Ku80-) cells and in human mammary epithelial MCF10A cells in the dose range of 0.05-1 Gy. The Chinese Hamster cells were exposed to 1 GeV/u Fe ions, 600 MeV/u Fe ions, and 300 MeV/u Fe ions (LETs of 151, 176 and 235 keV/{micro}m respectively) as well as with 320 kVp X-rays as reference. Second-order polynomials were fitted to the induction curves and the initial slopes (the alpha values) were u… more
Date: January 16, 2007
Creator: Groesser, Torsten; Chun, Eugene & Rydberg, Bjorn
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Partner: UNT Libraries Government Documents Department
open access

Fragmentation Cross Sections of Medium-Energy 35Cl, 40Ar, and 48TiBeams on Elemental Targets

Description: Charge-changing and fragment production cross sections at 0degrees have been obtained for interactions of 290, 400, and 650MeV/nucleon 40Ar beams, 650 and 1000 MeV/nucleon 35Cl beams, and a 1000MeV/nucleon 48Ti beam. Targets of C, CH2, Al, Cu, Sn, and Pb were used.Using standard analysis methods, we obtain fragment cross sections forcharges as low as 8 for Cl and Ar beams, and as low as 10 for the Tibeam. Using data obtained with small-acceptance detectors, we reportfragment production cross se… more
Date: December 8, 2007
Creator: Zeitlin, C.; Guetersloh, S.; Heilbronn, L.; Miller, J.; Fukumura,A.; Iwata, Y. et al.
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Partner: UNT Libraries Government Documents Department
open access

Promotion of Homologous Recombination and Genomic Stability byRAD51AP1 via RAD51 Recombinase Enhancement

Description: Homologous recombination (HR) repairs chromosome damage and is indispensable for tumor suppression in humans. RAD51 mediates the DNA strand pairing step in HR. RAD51AP1 (RAD51 Associated Protein 1) is a RAD51-interacting protein whose function has remained elusive. Knockdown of RAD51AP1 in human cells by RNA interference engenders sensitivity to different types of genotoxic stress. Moreover, RAD51AP1-depleted cells are impaired for the recombinational repair of a DNA double-strand break and exh… more
Date: April 11, 2007
Creator: Wiese, Claudia; Dray, Eloise; Groesser, Torsten; San Filippo,Joseph; Shi, Idina; Collins, David W. et al.
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Partner: UNT Libraries Government Documents Department
open access

Fragmentation Cross Sections of 290 and 400 MeV/nucleon 12C Beamson Elemental Targets

Description: Charge-changing and fragment production cross sections at 0circ have been obtained for interactions of 290 MeV/nucleon and 400MeV/nucleon carbon beams with C, CH2, Al, Cu, Sn, and Pb targets. Thesebeams are relevant to cancer therapy, space radiation, and the productionof radioactive beams. We compare to previously published results using Cand CH2 targets at similar beam energies. Due to ambiguities arising fromthe presence of multiple fragments on many events, previous publicationshave reporte… more
Date: March 17, 2007
Creator: Zeitlin, C.; Guetersloh, S.; Heilbronn, L.; Miller, J.; Fukumura,A.; Iwata, Y. et al.
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Partner: UNT Libraries Government Documents Department
open access

Extracellular Proteins Limit the Dispersal of BiogenicNanoparticles

Description: High spatial-resolution secondaryion microprobespectrometry, synchrotron radiation Fourier-transform infraredspectroscopy and polyacrylamide gel analysis demonstrate the intimateassociation of proteins with spheroidal aggregates of biogenic zincsulfide nanocrystals, an example of extracellular biomineralization.Experiments involving synthetic ZnS nanoparticles and representativeamino acids indicate a driving role for cysteine in rapid nanoparticleaggregation. These findings suggest that microbi… more
Date: April 27, 2007
Creator: Moreau, John W.; Weber, Peter K.; Martin, Michael C.; Gilbert,Benjamin; Hutcheon, Ian D. & Banfield, Jillian F.
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Partner: UNT Libraries Government Documents Department
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