Extensively Drug-Resistant Tuberculosis (XDR-TB): Emerging Public Health Threats and Quarantine and Isolation

Extensively Drug-Resistant Tuberculosis (XDR-TB): Emerging Public Health Threats and Quarantine and Isolation

Date: November 26, 2010
Creator: Swendiman, Kathleen S. & Jones, Nancy Lee
Description: This report the international saga of Andrew Speaker, a traveler thought to have XDR-TB, a drug-resistant form of tuberculosis, placed a spotlight on existing mechanisms to contain contagious disease threats and raised numerous legal and public health issues. It also discusses the application of various public health measures available to contain an emerging public health threat posed by an individual who ignores medical advice and attempts to board an airplane or take other forms of public transportation.
Contributing Partner: UNT Libraries Government Documents Department
The Global Fund to Fight AIDS, Tuberculosis, and Malaria: U.S. Contributions and Issues for Congress

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: U.S. Contributions and Issues for Congress

Date: August 3, 2010
Creator: Salaam-Blyther, Tiaji
Description: The Global Fund to Fight AIDS, Tuberculosis, and Malaria (Global Fund, or the Fund) was established in 2002 as a public-private partnership that could provide significant financial support for global responses to HIV/AIDS, tuberculosis (TB), and malaria. This report provides background information on the Global Fund, summarizes key findings on the Global Fund's progress through 2009, outlines U.S. funding for the Fund, and analyzes issues Congress might consider as it debates the appropriate level of support to provide the Fund.
Contributing Partner: UNT Libraries Government Documents Department
International HIV/AIDS, Tuberculosis, and Malaria: Key Changes to U.S. Programs and Funding

International HIV/AIDS, Tuberculosis, and Malaria: Key Changes to U.S. Programs and Funding

Date: July 14, 2008
Creator: Moss, Kellie
Description: This report describes U.S. efforts to combat international HIV/AIDS through the President's Emergency Plan for AIDS Relief (PEPFAR) including an overview of its implementation structure, key program elements, results, and funding from FY2004 through FY2008. It also details funding for tuberculosis, malaria, and U.S. contributions to the Global Fund during that time. This report discusses similarities and differences between H.R. 5501 and S. 2731 including proposed changes in program authorities and funding for HIV/AIDS, tuberculosis, and malaria programs.
Contributing Partner: UNT Libraries Government Documents Department
The Global Fund to Fight AIDS, Tuberculosis, and Malaria: Progress Report and Issues for Congress

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: Progress Report and Issues for Congress

Date: April 14, 2008
Creator: Salaam-Blyther, Tiaji
Description: This report discusses the Global Fund to Fight AIDS and its progress to date, describes the funding procedure, details U.S. contributions to the organization, and presents some issues regarding the level of U.S. contributions that Congress might consider.
Contributing Partner: UNT Libraries Government Documents Department
PEPFAR Reauthorization: Key Policy Debates and Changes to U.S. International HIV/AIDS, Tuberculosis, and Malaria Programs and Funding

PEPFAR Reauthorization: Key Policy Debates and Changes to U.S. International HIV/AIDS, Tuberculosis, and Malaria Programs and Funding

Date: January 29, 2009
Creator: Moss, Kellie
Description: This report provides background on the President’s Emergency Plan for AIDS Relief (PEPFAR) implementation and results. It details actual and requested funding for U.S. bilateral and multilateral efforts to fight HIV/AIDS, tuberculosis, and malaria globally through FY2009. It discusses key policy debates surrounding international HIV/AIDS, malaria, and tuberculosis programs and funding as the 110th Congress considered legislation to reauthorize PEPFAR programs.
Contributing Partner: UNT Libraries Government Documents Department
The Global Fund to Fight AIDS, Tuberculosis, and Malaria: Issues for Congress and U.S. Contributions from FY2001 to FY2013

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: Issues for Congress and U.S. Contributions from FY2001 to FY2013

Date: May 15, 2012
Creator: Salaam-Blyther, Tiaji & Kendall, Alexandra E.
Description: The Global Fund to Fight AIDS, Tuberculosis, and Malaria (Global Fund, or the Fund) was established in 2002 as a public-private partnership that could provide significant financial support for global responses to HIV/AIDS, tuberculosis (TB), and malaria. In November 2011, the Global Fund Board announced that due to inadequate resources from donors, it would cancel its 11th round of funding, but would maintain support for existing activities to avoid disruptions in ongoing services. Global health advocates urge Congress to meet the President's FY2013 request for the Fund in order to support the sustainability of its activities and to encourage continued contributions from other donors. Although Congress has traditionally been a strong supporter of the Fund, several issues may affect congressional views about the Fund in the future, which are discussed in this report.
Contributing Partner: UNT Libraries Government Documents Department
The Global Fund to Fight AIDS, Tuberculosis, and Malaria: Issues for Congress and U.S. Contributions from FY2001 to FY2013

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: Issues for Congress and U.S. Contributions from FY2001 to FY2013

Date: March 9, 2012
Creator: Salaam-Blyther, Tiaji & Kendall, Alexandra E.
Description: This report examines formal interagency collaborative arrangements and activities, which are intended to enhance joint efforts and cooperation among independent federal agencies with shared responsibilities and overlapping jurisdictions. This report highlights some of the current challenges posed by HIV/AIDS, TB, and malaria, as well as several crosscutting policy issues that the 112th Congress may consider as it determines U.S. global health funding for these three diseases, including: Health Systems Strengthening, Country Ownership, Research and Development, Monitoring and Evaluation; and Bilateral vs. Multilateral Support.
Contributing Partner: UNT Libraries Government Documents Department
The Global Challenge of HIV/AIDS, Tuberculosis, and Malaria

The Global Challenge of HIV/AIDS, Tuberculosis, and Malaria

Date: February 23, 2012
Creator: Kendall, Alexandra E.
Description: This report examines formal interagency collaborative arrangements and activities, which are intended to enhance joint efforts and cooperation among independent federal agencies with shared responsibilities and overlapping jurisdictions. This report highlights some of the current challenges posed by HIV/AIDS, TB, and malaria, as well as several crosscutting policy issues that the 112th Congress may consider as it determines U.S. global health funding for these three diseases, including: Health Systems Strengthening, Country Ownership, Research and Development, Monitoring and Evaluation; and Bilateral vs. Multilateral Support.
Contributing Partner: UNT Libraries Government Documents Department
The Global Challenge of HIV/AIDS, Tuberculosis, and Malaria

The Global Challenge of HIV/AIDS, Tuberculosis, and Malaria

Date: May 3, 2011
Creator: Kendall, Alexandra E.
Description: This report examines formal interagency collaborative arrangements and activities, which are intended to enhance joint efforts and cooperation among independent federal agencies with shared responsibilities and overlapping jurisdictions. This report highlights some of the current challenges posed by HIV/AIDS, TB, and malaria, as well as several crosscutting policy issues that the 112th Congress may consider as it determines U.S. global health funding for these three diseases, including: Health Systems Strengthening, Country Ownership, Research and Development, Monitoring and Evaluation; and Bilateral vs. Multilateral Support.
Contributing Partner: UNT Libraries Government Documents Department
The Global Fund to Fight AIDS, Tuberculosis, and Malaria: Issues for Congress and U.S. Contributions from FY2001 to the FY2012 Request

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: Issues for Congress and U.S. Contributions from FY2001 to the FY2012 Request

Date: July 1, 2011
Creator: Salaam-Blyther, Tiaji
Description: This report provides background information on the Global Fund, discusses changes the Global Fund has made to improve the efficiency of its programs and address allegations of corruption, outlines U.S. funding for the Fund, and analyzes issues Congress might consider as it debates the appropriate level of U.S support to provide the Fund.
Contributing Partner: UNT Libraries Government Documents Department
The Global Fund to Fight AIDS, Tuberculosis, and Malaria: U.S. Contributions and Issues for Congress

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: U.S. Contributions and Issues for Congress

Date: May 3, 2011
Creator: Salaam-Blyther, Tiaji
Description: This report provides background information on the Global Fund, discusses changes the Global Fund has made to improve the efficiency of its programs and address allegations of corruption, outlines U.S. funding for the Fund, and analyzes issues Congress might consider as it debates the appropriate level of support to provide the Fund.
Contributing Partner: UNT Libraries Government Documents Department
Tuberculosis: International Efforts and Issues for Congress

Tuberculosis: International Efforts and Issues for Congress

Date: May 1, 2008
Creator: Salaam-Blyther, Tiaji
Description: This report discusses the infectious disease outbreaks, such as H5N1 avian influenza and severe acute respiratory syndrome (SARS), and tuberculosis (TB). The World Health Organization (WHO) estimates that someone contracts TB every second and that about one-third of all people in the world carry TB; most of these cases, however, are latent
Contributing Partner: UNT Libraries Government Documents Department
U.S. Response to the Global Threat of HIV/AIDS: Basic Facts

U.S. Response to the Global Threat of HIV/AIDS: Basic Facts

Date: June 15, 2012
Creator: Kendall, Alexandra E.
Description: This report highlights some of the current challenges posed by HIV/AIDS, tuberculosis (TB), and malaria, as well as several crosscutting policy issues that the 112th Congress may consider as it determines U.S. global health funding for these three diseases, including: Health Systems Strengthening, Country Ownership, Research and Development, Monitoring and Evaluation; and Bilateral vs. Multilateral Support.
Contributing Partner: UNT Libraries Government Documents Department
U.S. Response to the Global Threat of HIV/AIDS: Basic Facts

U.S. Response to the Global Threat of HIV/AIDS: Basic Facts

Date: February 22, 2011
Creator: Kendall, Alexandra E.
Description: This report highlights some of the current challenges posed by HIV/AIDS, tuberculosis (TB), and malaria. as well as several policy issues that the 112th Congress may consider as it determines U.S. global health funding for these three diseases. Also examined are policy issues that the 112th Congress may consider, including health systems strengthening, country ownership, research and development, monitoring and evaluation, and bilateral vs. multilateral support.
Contributing Partner: UNT Libraries Government Documents Department
U.S. Response to the Global Threat of Tuberculosis: Basic Facts

U.S. Response to the Global Threat of Tuberculosis: Basic Facts

Date: June 15, 2012
Creator: Kendall, Alexandra E.
Description: This report outlines basic facts related to global tuberculosis (TB), including characteristics of the epidemic and U.S. legislation, programs, funding, and partnerships related to the global response to TB.
Contributing Partner: UNT Libraries Government Documents Department
U.S. Response to the Global Threat of Tuberculosis: Basic Facts

U.S. Response to the Global Threat of Tuberculosis: Basic Facts

Date: February 22, 2011
Creator: Kendall, Alexandra E.
Description: This report outlines basic facts related to global tuberculosis (TB), including characteristics of the epidemic and U.S. legislation, programs, funding, and partnerships related to the global response to TB.
Contributing Partner: UNT Libraries Government Documents Department
U.S. Response to the Global Threat of Tuberculosis: Basic Facts

U.S. Response to the Global Threat of Tuberculosis: Basic Facts

Date: January 5, 2012
Creator: Kendal, Alexandra E.
Description: Tuberculosis (TB) is one of the most widespread infectious diseases in the world, infecting an average of 9 million people annually. Although TB is curable, more than 1 million TB-related deaths occur each year. Due in part to a growing global response to TB, progress has been made in combating the disease. Globally, new TB infection rates have begun to slowly decline and TB mortality rates have decreased significantly since 1990. At the same time, absolute numbers of people infected with TB, particularly in Asia and Africa, continue to rise. Congress has recognized TB as an important humanitarian issue and increasingly as a potential threat to global security. In its second session, the 112th Congress will likely debate the appropriate funding levels and optimum strategy for addressing the continued challenge of global TB.
Contributing Partner: UNT Libraries Government Documents Department
The Global Fund to Fight AIDS, Tuberculosis and Malaria: Progress Report and Issues for Congress

The Global Fund to Fight AIDS, Tuberculosis and Malaria: Progress Report and Issues for Congress

Date: April 25, 2006
Creator: Salaam-Blyther, Tiaji
Description: The report discusses the progress and issues regarding the global fund to fight AIDS, tuberculosis, and malaria.
Contributing Partner: UNT Libraries Government Documents Department
The Global Fund to Fight AIDS, Tuberculosis and Malaria: Progress Report and Issues for Congress

The Global Fund to Fight AIDS, Tuberculosis and Malaria: Progress Report and Issues for Congress

Date: April 25, 2006
Creator: Salaam-Blyther, Tiaji
Description: The report discusses the progress and issues regarding the global fund to fight AIDS, tuberculosis, and malaria.
Contributing Partner: UNT Libraries Government Documents Department
Tuberculosis in the Nursing Home: A Policy and Procedure Manual

Tuberculosis in the Nursing Home: A Policy and Procedure Manual

Access: Use of this item is restricted to the UNT Community.
Date: May 2000
Creator: Mounts, Camilla M.
Description: Tuberculosis in the nursing home is an ever-growing problem for the health care community. The incidence of tuberculosis in the United States has risen alarmingly since 1982, and high-population environments such as nursing homes are among the places where it is most prevalent. The first part of this document is an introduction to the current concerns faced by nursing home infection control personnel. It includes information about the history, symptoms, and epidemiology of the disease, as well as other topics. The second part is a policy and procedure manual that contains a basic guide to methodical testing for tuberculosis, steps for dealing with active cases of the disease, and suggestions for education of nursing home health care workers.
Contributing Partner: UNT Libraries
Rapid Reagentless Detection of M. tuberculosis H37Ra in Respiratory Effluents

Rapid Reagentless Detection of M. tuberculosis H37Ra in Respiratory Effluents

Date: January 29, 2008
Creator: Adams, K L; Steele, P T; Bogan, M J; Sadler, N M; Martin, S; Martin, A N et al.
Description: Two similar mycobacteria, Mycobacteria tuberculosis H37Ra and Mycobacteria smegmatis are rapidly detected and identified within samples containing a complex background of respiratory effluents using Single Particle Aerosol Mass Spectrometry (SPAMS). M. tuberculosis H37Ra (TBa), an avirulent strain, is used as a surrogate for virulent tuberculosis (TBv); M. smegmatis (MSm) is utilized as a near neighbor confounder for TBa. Bovine lung surfactant and human exhaled breath condensate are used as first-order surrogates for infected human lung expirations from patients with pulmonary tuberculosis. This simulated background sputum is mixed with TBa or MSm and nebulized to produce conglomerate aerosol particles, single particles that contain a bacterium embedded within a background respiratory matrix. Mass spectra of single conglomerate particles exhibit ions associated with both respiratory effluents and mycobacteria. Spectral features distinguishing TBa from MSm in pure and conglomerate particles are shown. SPAMS pattern matching alarm algorithms are able to distinguish TBa containing particles from background matrix and MSm for >50% of the test particles, which is sufficient to enable a high probability of detection and a low false alarm rate if an adequate number of such particles are present. These results indicate the potential usefulness of SPAMS for rapid, reagentless tuberculosis screening.
Contributing Partner: UNT Libraries Government Documents Department
Development of Oral Fomulation of SCV-07 for Use in Tuberculosis

Development of Oral Fomulation of SCV-07 for Use in Tuberculosis

Date: November 16, 2007
Creator: None
Description: An evaluation of the immunomodulatory peptide SCV-07 was conducted as a possible therapeutic treatment for tuberculosis. This evaluation included mouse models, clinical trials and various forms of the drug such as liquid injection and development of an oral pill. It was found that SCV-07 significantly increased the survival rate of animals infected with lethal doses of Mycobacterium bovis. It enhanced the functional activity of macrophages in a dose-dependent fashion. The combination of SCV-07 with bacteriostatic drugs, such as izoniazid, was particularly effective. Phase II clinical trials in a TB clinic demonstrated that the usage of the injection form of SCV-07 for lung TB treatment in combination with standard chemotherapy decreased the quantity of patients with positive sputum assays for Mycobacteria, promoted healing of cavities in lungs, stabilized parameters of cell immunity, and resulted in a significant improvement in the general condition of patients. Clinical trials results of the oral drug form are still being evaluated.
Contributing Partner: UNT Libraries Government Documents Department