Characteristics of Primary Cilia and Centrosomes in Neuronal and Glial Lineages of the Adult Brain
Description:
Primary cilia are sensory organelles that are important for initiating cell division in the brain, especially through sonic hedgehog (Shh) signaling. Several lines of evidence suggest that the mitogenic effect of Shh requires primary cilia. Proliferation initiated by Shh signaling plays key roles in brain development, in neurogenesis in the adult hippocampus, and in the generation of glial cells in response to cortical injury. In spite of the likely involvement of cilia in these events, little …
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Date:
May 2015
Creator:
Bhattarai, Samip Ram
Partner:
UNT Libraries