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Study of the mechanism of carcinogenesis by carcinogens which are negative in the Ames test. Progress report. [ICE; TUMOR PROMOTERS; PROGESTERONE; QUANTITY RATIO; RATS]

Description: Research progress for 1980 is reported. The role of tRNA methyltransferases in two-1 stage carcinogenesis of mice by phorbol esters has been investigated. The mechanisms of elevation of progesterone levels in the rat by ethionine have also beed studied. (ACR)
Date: unknown
Creator: Borek, E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Synthesis of high specific activity (1- sup 3 H) farnesyl pyrophosphate

Description: The synthesis of tritiated farnesyl pyrophosphate with high specific activity is reported. trans-trans Farnesol was oxidized to the corresponding aldehyde followed by reduction with lithium aluminium tritide (5%-{sup 3}H) to give trans-trans (1-{sup 3}H)farnesol. The specific radioactivity of the alcohol was determined from its triphenylsilane derivative, prepared under very mild conditions. The tritiated alcohol was phosphorylated by initial conversion to an allylic halide, and subsequent trea… more
Date: August 1, 1991
Creator: Saljoughian, M.; Morimoto, H. & Williams, P. G.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Charge separation in photoredox reactions

Description: This report deals with the photoreduction of alkylmethylviologens in vesicles in which the combined effect of the alkylmethylviologen chain length and the addition of cholesterol to the vesicle system has been assessed. Although the alkyl chain length effect predominately controls the photoreduction yield it is shown that cholesterol addition can tune the magnitude of this effect. A series of neutral alkylphenothiazines has been synthesized and the effect of alkyl chain length in variously char… more
Date: October 1, 1991
Creator: Kevan, L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Principles and major agents in clinical oncology chemotherapy

Description: This paper provides a brief classification of drugs available for veterinary chemotherapy, as well as justifications for their use. Some common neoplasia and the drugs of choice for their treatment are described. A listing by class of systemic chemotherapeutic agents, their mode of action, tumors responsive to the drugs, precautions and common adverse effects and mode of administration is provided. 2 tabs. (MHB)
Date: October 1, 1991
Creator: Weller, R. E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Cell-mediated mutagenesis and cell transformation by chemical carcinogens

Description: Results are reported from studies that showed that mutagenesis of mammalian cells can be achieved by carcinogenic polycyclic hydrocarbons, nitrosamines, and aflatoxins when tested in the presence of fibroblasts and hepatocytes which are able to metabolize these carcinogens. Further, we have found that there is a relationship between the degree of mutant induction and the degree of carcinogenicity of the different chemicals tested. By simultaneously measuring the frequency of cell transformation… more
Date: January 1, 1977
Creator: Huberman, E. & Langenbach, R.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Selenium and tellurium as carbon substitutes

Description: This review has summarized structure-activity studies with /sup 75/Se- and /sup 123m/Te-labeled radiopharmaceuticals in which the selenium or tellurium heteroatom has been inserted between carbon-carbon bonds. The agents that have been investigated in most detail include steroids for adrenal imaging and long-chain fatty acids, and a variety of other unique agents have also been studied. Because of the great versatility of the organic chemistry of selenium and tellurium, there is continuing inte… more
Date: January 1, 1980
Creator: Knapp, F. F. Jr.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Nuclear medicine technology. Progress report for quarter ending September 30, 1979

Description: Adrenal uptake in rats of /sup 117m/Sn-labeled 23-(trimethyl stanna)-24-nor-5..cap alpha..-cholan-3..beta..-o1 is demonstrated. The adrenal:blood and adrenal:liver ratios were 33:1 and 9:1, only one day after intravenous administration. A variety of /sup 117m/Sn-labeled steroids with structural modifications were also prepared to determine their effects on the adrenal uptake of these unusual steroids. Structural features required for significant adrenal uptake were determined. The diffusion cha… more
Date: January 1, 1979
Creator: Knapp, F. F. Jr.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Biochemical endpoints of glucocorticoid hormone action

Description: Both the rapidly evolving metabolic effects of glucocorticoids and the more slowly developing lethal actions appear to be initiated via the synthesis of new mRNAs and proteins. The chronic suppression of cell growth may be the consequence of suppression of overall rates of protein synthesis (and probably RNA and DNA synthesis as well) that in turn may represent the cellular response to the small changes in ratios of adenine nucleotides that result from the suppression of oxidative ATP productio… more
Date: January 1, 1978
Creator: Young, D. A.; Nicholson, M. L.; Guyette, W. A.; Giddings, S. J.; Mendelsohn, S. L.; Nordeen, S. K. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Nuclear medicine technology progress report for quarter ending June 30, 1979

Description: Diffusion chamber assay system studies on the relative cytotoxicity and target cell uptake of /sup 195m/Pt-labeled cis- and trans-dichlorodiammineplatinum(II) (cis- and trans-DDP) are reported. These two agents are excellent candidates for such studies since cis-DDP is an established potent antitumor agent while the trans-isomer exhibits little antitumor activity. The KB tumor cell population in chambers from the cis-DDP-treated animals decreased while the cell population in chambers from the t… more
Date: August 1, 1979
Creator: Knapp, F. F. Jr.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

(Radiolabeled androgens and progestins as imaging agents for tumors of the prostate and breast)

Description: The specific aims of the previous grant application can be summarized as follows: Synthesize fluorine-substituted progestins from the following high affinity classes: R5020 (promegestone), norgestrel, RU486, and retroprogestins; Synthesize fluorine-substituted androgens from the following high affinity classes: mibolerone, R1881 (metribolone) and 2-oxometribolone; Evaluate the receptor binding and non-specific binding of these fluorosteroids by in vitro binding assays; Develop and optimize fluo… more
Date: January 1, 1991
Creator: Katzenellenbogen, J.A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Health and safety research division. Nuclear medicine technology progress report for period ending March 31, 1979

Description: The preparation of a unique class of trimethyltin-substituted steroids is described that were designed because of the potential use of the /sup 117m/Sn-labeled analogs for adrenal imaging. The trimethyltin-substituted steroids were readily prepared on the microscale in yields ranging from 40 to 80%. Studies with the /sup 123m/Te-labeled fatty acids have continued, and radiolabeled 6-telluraheptadecanoic acid and 11-telluraheptadecanoic acid have shown pronounced heart uptake in rats. These resu… more
Date: August 1, 1979
Creator: Knapp, F. F. Jr.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Anticancer chemotherapy

Description: This document examines chemotherapeutic agents for use in veterinary oncology. It lists some of the most common categories of chemotherapeutic drugs, such as alkylating agents and corticosteroids. For each category, the paper lists some example drugs, gives their mode of action, tumors usually susceptible to the drug, and common side effects. A brief discussion of mechanisms of drug resistance is also provided. (MHB)
Date: October 1, 1991
Creator: Weller, R. E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Mammary tumors and serum hormones in the bitch treated with medroxyprogesterone acetate or progesterone for four years

Description: After four years of a long term contraceptive steroid safety study, the incidence and the histologic type of mammary dysplasia produced is similar in beagles treated with medroxyprogesterone acetate (medroxyprogesterone) or progesterone. Serum insulin, thyroid stimulating hormone (TSH), triiodothyronine, growth hormone, prolactin, 17..beta..-estradiol, progesterone, and cortisol were determined by radioimmunoassay on samples collected after 45 months of treatment. Serum growth hormone and insul… more
Date: January 1, 1978
Creator: Frank, D. W.; Kirton, K. T.; Murchison, T. E.; Quinlan, W. J.; Coleman, M. E.; Gilbertson, T. J. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Efficient microscale preparation of tin-117m-tin tetrachloride-a pivotal intermediate for the synthesis of tin-117m-labeled radiopharmaceuticals

Description: A microscale technique has been developed for the preparation of /sup 117m/SnCl/sub 4/. The radiolabeled tin tetrachloride is an important intermediate for the synthesis of /sup 117m/Sn-labeled organic radiopharmaceuticals. The flow-through system involves high temperature chlorination of metallic /sup 117m/Sn with subsequent cryogenic collection of the /sup 117m/SnCl/sub 4/ in a special reaction vessel. This vessel can then be used for the conversion of the tin tetrachloride to various useful … more
Date: January 1, 1979
Creator: Woo, David V.; Knapp, Furn F., Jr.; Butler, Thomas A. & Callahan, Alvin P.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Bile Salt Surfactants in Micellar Electrokinetic Capillary Chromatography: Application to Hydrophobic Molecule Separations

Description: Bile Salt surfactants are used in the micellar electrokinetic capillary chromatography (MECC) separation of various hydrophobic compounds. The use of methanol in the mobile phase allows the separation of previously intractable compounds including polyaromatic hydrocarbons. The effects of methanol on critical micelle concentration is investigated for sodium dodecyl sulfate (SDS) and the bile salt sodium cholate. It is determined that the unique structure of the bile salt micelle is much more tol… more
Date: January 1, 1990
Creator: Cole, Roderic O.; Sepaniak, Michael J.; Hinze, Willie L.; Gorse, Joseph & Oldiges, Kimberly
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Solvent Tailoring in Coal Liquefaction. Quarterly Report, February 1982-May 1982. [In Many Cases the Simple Organic Compounds Listed Were Hydrogenated]

Description: Twenty-three model donor solvents were used to rank their efficacy for the dissolution of Western Kentucky No. 9/14 coal. The transfer of hydrogen from the solvent to the coal fragments, as measured by coal conversion, was examined at three levels of available hydrogen. The hydrogen donors are ranked according to their ability to convert coal to THF solubles. Aromatic analogs of the model donors showed little ability to convert coal to THF solubles. Factors which influence hydrogen donation inc… more
Date: January 1, 1982
Creator: Tarrer, A. R.; Guin, J. A.; Curtis, C. W. & Williams, D. C.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Radiolabeled androgens and progestins as imaging agents for tumors of the prostate and breast

Description: We are preparing progestins and androgens, labeled with the single photon emitters technetium-99m and rhenium-186 and the positron-emitting radionuclide fluorine-18. In both cases, ligands selected have very high affinity for the respective receptor, low affinity for blood and non-specific binders and to be reasonably resistant to metabolism: The progestins will be derivatives of the potent progestins ORG2058, norgestrel, RU486, and an unusual retroprogestin and the androgens will be derivative… more
Date: August 8, 1992
Creator: Katzenellenbogen, J.A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Detection of atypical bile acids in disease states and their identification by gas chromatography-mass spectrometry-computer techniques

Description: The study of the bile acid constituents of serum, bile, urine, and stool of patients exhibiting liver disease has increased in importance with the availability of newer methods for their detection and identification. A cogent question for study has been whether specific bile acids are toxic and thus are the cause of liver disease, or whether they accumulate as a result of disease-induced alteration in metabolism. Examining a wide variety of clinical samples, we have observed that many patients … more
Date: January 1, 1978
Creator: Szczepanik-Van Leeuwen, P. A. & Stellaard, F.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Specific allogeneic unresponsiveness in the adult host: present-day experimental models

Description: As part of a long-term intensive effort to apply the induction of adult allogensic unresponsiveness to the transplantation problem, two techniques to control the variability in the persistence of immunologically competent postthymic cells iin the treated host and/or the inoculum of autologous marrow returned to the host after irradiation are described. The first consisted of exposing the peripheral blood of prospective recipients to a 5-week course of extra-corporeal irradiation (ECIB), the oth… more
Date: January 1, 1982
Creator: Rapaport, F.T.; Bachvaroff, R.J.; Cronkite, E.; Chanana, A.; Sato, T.; Asari, H. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Interactive radiopharmaceutical facility between Yale Medical Center and Brookhaven National Laboratory. Progress report, November 1, 1980-October 31, 1981

Description: Research conducted in three principal areas is discussed and summarized. (1) Investigation of the influence of antiarrhythmic agents, such as lidocaine and procainamide, on the chemotaxis and nylon fiber adherence of indium-111-labelled human polymorphonulcear leukocytes (PMNs) in vitro revealed that at normal therapeutic levels of lidocaine and procaine, the adherence and chemotactic function of In-111-PMNs remain unaltered. Results with higher therapeutic blood levels are also discussed. (2) … more
Date: unknown
Creator: Gottschalk, A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Development and application of resistive pulse spectroscopy: studies on the size, form and deformability of red blood cells

Description: The following studies were conducted using the resistive pulse spectroscopy (RPS) technique: cumulative spectra and individual pulse forms for rigid latex polymer spheres; acquisition and analysis of RPS spectral data by means of special computer program; interaction of red blood cells with glutaraldehyde; membrane properties of erythrocytes undergoing abrupt osmotic hemolysis; reversible effects of the binding of chlorpromazine HCl at the red cell membrane surface; effects of high cholesterol … more
Date: January 1979
Creator: Yee, J. P.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Nuclear Medicine Technology. Progress Report for Quarter Ending September 30, 1978

Description: A unique class of radiopharmaceuticals labeled with the /sup 117m/Sn nuclide has been developed. The attractive properties of /sup 117m/Sn include a 14-day physical half-life and the emission of a single ..gamma..-photon with an optimal energy of 159 keV. A specialized apparatus was designed for the conversion of metallic /sup 117m/Sn to /sup 117m/SnCl/sub 4/ which was subsequently converted to a variety of useful /sup 117m/Sn-labeled organotin intermediates. The availability of this unique app… more
Date: February 1, 1979
Creator: Knapp, Furn F., Jr.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

(Development of Bromine-77 from the LAMPF facility)

Description: The objective of the work was to conduct the necessary studies required to evaluate the efficacy, potential benefit and role of bromine-77 labeled steroids in the detection and evaluation of treatment for hormone-dependent tumors. This report presents progress on the following tasks: An initial investigation concentrating on the radiobromination at carbon-6 or carbon-7 in selected simple steroids utilizing the nuclides, bromine-82 and bromine-77, analytical spectroscopy of radiolabeled compound… more
Date: January 1, 1989
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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