International Convention Against Doping in Sport: Issues for Congress

International Convention Against Doping in Sport: Issues for Congress

Date: May 28, 2008
Creator: Wyler, Liana Sun
Description: The International Convention Against Doping in Sport seeks to harmonize anti-doping commitments for non-professional sports at the international level. This Convention was adopted by the United Nations Educational, Scientific, and Cultural Organization (UNESCO) in 2005 and entered in force on February 1, 2007. Issues that could arise as the Senate considers the treaty include its relationship to anti-doping regulations in professional sports, potential consequences that non-ratification could pose to the United States, and the legitimacy and effectiveness of current international anti-doping activities.
Contributing Partner: UNT Libraries Government Documents Department
International Convention Against Doping in Sport: Issues for Congress

International Convention Against Doping in Sport: Issues for Congress

Date: June 26, 2008
Creator: Wyler, Liana Sun
Description: The International Convention Against Doping in Sport seeks to harmonize anti-doping commitments for non-professional sports at the international level. Issues that could arise as the Senate considers the Convention include its relationship to anti-doping regulations in professional sports, potential consequences that non-ratification could pose to the United States, and the legitimacy and effectiveness of current international anti-doping activities.
Contributing Partner: UNT Libraries Government Documents Department
International Convention Against Doping in Sport: Issues for Congress

International Convention Against Doping in Sport: Issues for Congress

Date: August 11, 2008
Creator: Wyler, Liana Sun
Description: The International Convention Against Doping in Sport seeks to harmonize anti-doping commitments for non-professional sports at the international level. Issues that may continue to arise as policymakers evaluate the Convention include its relationship to anti-doping regulations in professional sports and the legitimacy and effectiveness of current international anti-doping activities.
Contributing Partner: UNT Libraries Government Documents Department
Biomedical Research Group, Health Division annual report 1954

Biomedical Research Group, Health Division annual report 1954

Date: December 1955
Creator: Langham, W. H. & Storer, J. B.
Description: This report covers the activities of the Biomedical Research Group (H-4) of the Health Division during the period January 1 through December 31, 1954. Organizationally, Group H-4 is divided into five sections, namely, Biochemistry, Radiobiology, Radiopathology, Biophysics, and Organic Chemistry. The activities of the Group are summarized under the headings of the various sections. The general nature of each section`s program, publications, documents and reports originating from its members, and abstracts and summaries of the projects pursued during the year are presented.
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EFFECTS OF X-IRRADIATION ON STEROID BIOTRANSFORMATIONS BY TESTICULAR TISSUE. Technical Progress Report.

EFFECTS OF X-IRRADIATION ON STEROID BIOTRANSFORMATIONS BY TESTICULAR TISSUE. Technical Progress Report.

Date: January 1, 1971
Creator: Ellis, L.C.
Description: None
Contributing Partner: UNT Libraries Government Documents Department
EFFECTS OF IONIZING RADIATION ON ENDOCRINE CELLS. VII. ANDROGEN SYNTHESIS AND METABOLISM BY RAT TESTICULAR MINCED AND TEASED-TUBULAR PREPARATIONS AFTER 450 r OF WHOLE-BODY X-IRRADIATION.

EFFECTS OF IONIZING RADIATION ON ENDOCRINE CELLS. VII. ANDROGEN SYNTHESIS AND METABOLISM BY RAT TESTICULAR MINCED AND TEASED-TUBULAR PREPARATIONS AFTER 450 r OF WHOLE-BODY X-IRRADIATION.

Date: October 31, 1971
Creator: Ellis, L.C. & Van Kampen, R.
Description: None
Contributing Partner: UNT Libraries Government Documents Department
PAPER CHROMATOGRAPHY OF STEROIDS

PAPER CHROMATOGRAPHY OF STEROIDS

Date: July 28, 1950
Creator: Kritchevsky, David & Calvin, M.
Description: A method for the paper chromatography of sterols involving impregnated paper has been developed.
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Review of Androgenic Anabolic Steroid Use

Review of Androgenic Anabolic Steroid Use

Date: July 31, 2001
Creator: Borges, T.; Eisele, G. & Byrd, C.
Description: An area that has been overlooked within personnel security evaluations is employee use of androgenic-anabolic steroids (AAS). Current drug testing within the federal government does not include testing for anabolic steroids, and the difficulties to implement such testing protocols-not to mention the cost involved-make AAS testing highly improbable. The basis of this report is to bring to the forefront the damage that anabolic steroids can cause from both a physical and a psychological standpoint. Most individuals who use AASs do so to increase their muscle mass because they wish to gain some type of competitive edge during athletic competition or they wish to enhance their physical features for self-satisfaction and self-esteem (i.e., body building). Security officers are one group of men who often take high doses of anabolic steroids, according to the Second Report of the Senate Standing Committee (1990). The negative psychological characteristics for AAS use is extensive and includes prominent hostility, aggressiveness, irritability, euphoria, grandiose beliefs, hyperactivity, reckless behavior, increased sexual appetite, unpredictability, poor impulse control, mood fluctuations, and insomnia. The drug may invoke a sense of power and invincibility (Leckman and Scahill, 1990). Depressive symptoms, such as anhedonia, fatigue, impaired concentration, decreased libido, and even suicidality (Pope ...
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Novel Chemical Strategies for Labeling Small Molecule Ligands for Androgen, Progestin, and Peroxisome Proliferator-Activated Receptors for Imaging Prostate and Breast Cancer and the Heart

Novel Chemical Strategies for Labeling Small Molecule Ligands for Androgen, Progestin, and Peroxisome Proliferator-Activated Receptors for Imaging Prostate and Breast Cancer and the Heart

Date: April 19, 2007
Creator: Katzenellenbogen, John, A.
Description: Summary of Progress The specific aims of this project can be summarized as follows: • Aim 1: Prepare and evaluate radiolabeled ligands for the peroxisome proliferator-activated receptor  (PPAR), a new nuclear hormone receptor target for tumor imaging and hormone therapy. • Aim 2: Prepare steroids labeled with a cyclopentadienyl tricarbonyl technetium or rhenium unit. • Aim 3: Prepare and evaluate other organometallic systems of novel design as ligand mimics and halogenated ligands for nuclear hormone receptor-based tumor imaging. As is described in detail below, we made excellent progress on all three of these aims; the highlights of our progress are the following: • we have prepared the first fluorine-18 labeled analogs of ligands for the PPAR receptor and used these in tissue distribution studies in rats • we have developed three new methods for the synthesis of cyclopentadienyltricarbonyl rhenium and technetium (CpRe(CO)3 and CpTc(CO)3) systems and we have adapted these to the synthesis of steroids labeled with these metals, as well as ligands for other receptor systems • we have prepared a number of fluorine-18 labeled steroidal and non-steroidal androgens and measured their tissue distribution in rats • we have prepared iodine and bromine-labeled progestins with high progesterone receptor ...
Contributing Partner: UNT Libraries Government Documents Department
A novel approach to the study of the functional proteome in breast cancer

A novel approach to the study of the functional proteome in breast cancer

Date: October 10, 2008
Creator: Hennessy, Bryan; Lu, Yiling; Gonzalez-Angulo, Ana Maria; Carey, Mark; Myhre, Simen; Ju, Zhenlin et al.
Description: Factors including intratumoral heterogeneity and variability in tissue handling potentially hamper the application of reverse phase protein arrays (RPPA) to study of the solid tumor functional proteome. To address this, RPPA was applied to quantify protein expression and activation in 233 human breast tumors and 52 breast cancer cell lines. Eighty-two antibodies that recognize kinase and steroid signaling events and their effectors were validated for RPPA because of the importance of these proteins to breast carcinogenesis. Reproducibility in replicate lysates was excellent. Intratumoral protein expression was less variable than intertumoral expression, and prognostic biomarkers retained the ability to accurately predict patient outcomes when analyzed in different tumor sites. Although 21/82 total and phosphoproteins demonstrated time-dependent instability in breast tumors that were placed at room temperature after surgical excision for 24 hours prior to freezing, the functional proteomic 'fingerprint' was robust in most tumors until at least 24 hours before tissue freezing. Correlations between RPPA and immunohistochemistry were statistically significant for assessed proteins but RPPA demonstrated a superior dynamic range and detected, for example, an 866-fold difference in estrogen receptor alpha level across breast tumors. Protein and mRNA levels were concordant (at p {le} 0.05) for 41.3% and 61.1% of assayed ...
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Targeted Radiotherapy of Estrogen Receptor Positive Tumors

Targeted Radiotherapy of Estrogen Receptor Positive Tumors

Date: August 31, 2006
Creator: Rajagopalan, Raghavan
Description: The overall objectives of the proposal were to develop estrogen receptor (ER) binding small molecule radiopharmaceuticals for targeted radiotherapy of ER positive (ER+) tumors. In particular, this proposal focused on embedding a {sup 186,188}Re or a {sup 32}P radionuclide into an estrogen steroidal framework by isosteric substitution such that the resulting structure is topologically similar to the estrogen (estrogen mimic). The estrogen mimic molecules expected to bind to the ER and exhibit biodistribution akin to that of native estrogen due to structural mimicry. It is anticipated that the {sup 186,188}Re- or a {sup 32}P-containing estrogen mimics will be useful for targeted molecular radiotherapy of ER+ tumors. It is well established that the in vivo target tissue uptake of estrogen like steroidal molecules is related to the binding of the steroids to sex hormone binding globulin (SHBG). SHBG is important in the uptake of estrogens and testosterone in target tissues by SHBG receptors on the cell surface. However, hitherto the design of estrogen like small molecule radiopharmaceuticals was focused on optimizing ER binding characteristics without emphasis on SHBG binding properties. Consequently, even the molecules with good ER affinity in vitro, performed poorly in biodistribution studies. Based on molecular modeling studies the ...
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A STUDY OF THE EFFECTS OF NUCLEAR RADIATION ON ORGANIC EXPLOSIVES

A STUDY OF THE EFFECTS OF NUCLEAR RADIATION ON ORGANIC EXPLOSIVES

Date: January 1, 1960
Creator: Urizar, M.J.; Loughran, E.D. & Smith, L.C.
Description: Samples of 6 explosive compounds (TNT, tetryl, NC, ROX, HMX, and PETN) and 4 explosive mixtures were exposed to the neutron and gamma radiation from a power reactor at integrated flux levels of approximately 10/sup 15/ and 3 x 10/ sup 16/ n/cm/sup 2/. The irradiated samples were subjected to a variety of chemical and physical tests. Only minor effects were noted at the lower exposure level, but extensive deterioration of the aliphatic and and heterocyclic compounds occurred in the 10/sup 16/ run. G-values of 2.9 and 1.4 were obtained for the destruction of ROX and HMX, respectively. An experiment in which samples of 5 explosive compounds and mixtures were exposed to a radiation burst from the Godiva II critical assembly is described. No significant damage to the samples resulted from this exposure. (auth)
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Non-carrier-added 186, 188Re labeled 17a-ethynylestradiol : a potential breast cancer imaging and therapy agent

Non-carrier-added 186, 188Re labeled 17a-ethynylestradiol : a potential breast cancer imaging and therapy agent

Date: January 1, 2001
Creator: Fassbender, M. E. (Michael E.); Phillips, Dennis R.; Peterson, E. J. (Eugene J.); Ott, K. C. (Kevin C.) & Arterburn, J. B. (Jeffrey B.)
Description: Receptor-targeted radiopharmaceuticals constitute potential agents for the diagnosis and therapy of cancer. Breast cancer is the most prevalent form of diagnosed cancer in women in the United States, and it accounts for the second highest number of cases of cancer fatalities (1). In Approximately two-thirds of the breast tumors, estrogen and progesterone steroid hormone receptors can be found. Such tumors can often be treated successfully with anti-estrogen hormone therapy (2). Hence, the ability to determine the estrogen receptor (ER) contend of the breast tumor is essential for making the most appropriate choice of treatment for the patient. Along with this diagnostic aspect, steroid-based radiopharmaceuticals with high specific activity offer an encouraging prospect for therapeutic applications: {sup 186,188}Re labeled steroids binding to receptors expressed by cancer cells appear to be potential agents for the irradiation of small to medium-sized tumors. {sup 186}Re has been regarded as an ideal radionuclide for radiotherapy due to its appropriate half-live of 90 h and {beta}-energy of 1.07 MeV. Moreover, the {gamma}-emission of 137 keV that allows in vivo imaging while in therapy is an additional bonus. {sup 188}Re is obtained from a {sup 188}W/{sup 188}Re radionuclide generator system, representing an advantage for availability at radiopharmacy ...
Contributing Partner: UNT Libraries Government Documents Department