Identifying genetic interactions of the spindle checkpoint in Caenorhabditis elegans.
Description:
Faithful segregation of chromosomes is ensured by the spindle checkpoint. If a kinetochore does not correctly attach to a microtubule the spindle checkpoint stops cell cycle progression until all chromosomes are attached to microtubules or tension is experienced while pulling the chromosomes. The C. elegans gene, san-1, is required for spindle checkpoint function and anoxia survival. To further understand the role of san-1 in the spindle checkpoint, an RNAi screen was conducted to identify gen…
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Date:
May 2009
Creator:
Stewart, Neil
Partner:
UNT Libraries