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Radiation enhancement with /sup 127/I-deoxyuridine

Description: A technique for radiation enhancement of photon radiotherapy is outlined. High LET radiations in the form of Auger electron distributions are generated by photoactivation of stable iodine incorporated as iodinated deoxyuridine (IdUrd). Of the several halogenated deoxyribonucleosides evaluated, IdUrd was found to be the only thymidine analog providing effective photoactivation. This mechanism is combined with radiation sensitization to produce an overall radiation enhancement. Calculations show … more
Date: June 1, 1982
Creator: Fairchild, R.G.
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Partner: UNT Libraries Government Documents Department
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Principles and major agents in clinical oncology chemotherapy

Description: This paper provides a brief classification of drugs available for veterinary chemotherapy, as well as justifications for their use. Some common neoplasia and the drugs of choice for their treatment are described. A listing by class of systemic chemotherapeutic agents, their mode of action, tumors responsive to the drugs, precautions and common adverse effects and mode of administration is provided. 2 tabs. (MHB)
Date: October 1, 1991
Creator: Weller, R. E.
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Partner: UNT Libraries Government Documents Department
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Radiobiology of pions at LAMPF

Description: Recent radiobiology data for pion beams used in therapy are presented. The biological systems used were cultured cells suspended in gelatin and intestinal crypt assay. The importance of fast neutrons from pion stars in large treatment volumes is discussed. The data for compensating the depth dose distribution to produce uniform cell killing across the peak region are presented. The changes in biological effectiveness with peak width for pion beams (unlike heavy ions) are small because of fast n… more
Date: January 1, 1982
Creator: Raju, M.R. & Tokita, N.
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Partner: UNT Libraries Government Documents Department
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Proton linac for hospital-based fast neutron therapy and radioisotope production

Description: Recent developments in linac technology have led to the design of a hospital-based proton linac for fast neutron therapy. The 180 microamp average current allows beam to be diverted for radioisotope production during treatments while maintaining an acceptable dose rate. During dedicated operation, dose rates greater than 280 neutron rads per minute are achievable at depth, DMAX = 1.6 cm with source to axis distance, SAD = 190 cm. Maximum machine energy is 70 MeV and several intermediate energie… more
Date: September 1, 1989
Creator: Lennox, A. J.; Hendrickson, F. R.; Swenson, D. A.; Winje, R. A.; Young, D. E. (Fermi National Accelerator Lab., Batavia, IL (USA); Rush Univ., Chicago, IL (USA) et al.
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Partner: UNT Libraries Government Documents Department
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Application of protons to computer tomography

Description: It was demonstrated that the application of protons to computed tomography can result in a significant dose advantage relative to x rays. Thus, at the same dose as is delivered by contemporary commercial x-ray scanners, a proton scanner could produce reconstructions with a factor of 2 or more improvement in density resolution. Whether such an improvement can result in significantly better diagnoses of human disease is an open question which can only be answered by the implementation of a proton… more
Date: January 1, 1977
Creator: Hanson, K. M.; Bradbury, J. N.; Cannon, T. M.; Hutson, R. L.; Laubacher, D. B.; Macek, R. et al.
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Partner: UNT Libraries Government Documents Department
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Dosimetric implications of new compounds for neutron capture therapy (NCT)

Description: Systemic application of radiolabeled or cytotoxic agents should allow targeting of primary and metastatic neoplasms on a cellular level. In fact, drug uptake in non-target cell pools often exceeds toxic levels before sufficient amounts are delivered to tumor. In addition, at the large concentration of molecules necessary for therapy, effects of saturation are often found. Application of NCT can circumvent problems associated with high uptake in competing non-target cell pools, as the /sup 10/B(… more
Date: January 1, 1982
Creator: Fairchild, R.G.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Distributed Microprocessor Automation Network for Synthesizing Radiotracers Used in Positron Emission Tomography

Description: This presentation describes an evolving distributed microprocessor network for automating the routine production synthesis of radiotracers used in Positron Emission Tomography. We first present a brief overview of the PET method for measuring biological function, and then outline the general procedure for producing a radiotracer. The paper identifies several reasons for our automating the syntheses of these compounds. There is a description of the distributed microprocessor network architecture… more
Date: September 1, 1984
Creator: Russell, J. A. G.; Alexoff, D. L. & Wolf, A. P.
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Partner: UNT Libraries Government Documents Department
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Heavy-ion radiography and heavy-ion computed tomography

Description: Heavy-ion projection and CT radiography is being developed into a safe, low-dose, noninvasive radiological procedure that can quantitate and image small density differences in human tissues. The applications to heavy-ion mammography and heavy-ion CT imaging of the brain in clinical patients suggest their potential value in cancer diagnosis.
Date: February 1, 1982
Creator: Fabrikant, J. I.; Holley, W. R.; McFarland, E. W. & Tobias, C. A.
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Partner: UNT Libraries Government Documents Department
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Improved radioimmunotherapy of hematologic malignancies

Description: This research project proposes to develop novel new approaches of improving the radioimmunodetection and radioimmunotherapy of malignancies by augmenting retention of radioimmunoconjugates by tumor cells. The approaches shown to be effective in these laboratory experiments will subsequently be incorporated into out ongoing clinical trials in patients. Specific project objectives include: to study the rates of endocytosis, intracellular routing, and metabolic degradation of radiolabeled monoclon… more
Date: March 24, 1992
Creator: Press, O.W.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Pulsed system for obtaining microdosimetric data with high intensity beams

Description: The use of heavy particle accelerators for radiation therapy requires high intensity beams in order to produce useful dose rates. The 800-MeV proton beam at LAMPF passes through different production targets to generate secondary pion beams. Conventional microdosimetric techniques are not applicable under these conditions because exceedingly high count rates result in detector damage, gas breakdown, and saturation effects in the electronics. We describe a new microdosimetric system developed at … more
Date: January 1, 1977
Creator: Zaider, M.; Dicello, J.F. & Hiebert, R.D.
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Partner: UNT Libraries Government Documents Department
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Annual progress report, July 1, 1979-June 30, 1980

Description: Research progress is reported for the year 1979-1980. The report is divided into sections dealing individually with the divisions of Biomolecular and Cellular Science, Environmental Biology, and Nuclear Medicine. The sections have been individually entered into EDB. (ACR)
Date: January 1, 1980
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Pion production cross sections and associated parameters

Description: Negative pions have been used for radiotherapy at the meson factories LAMPF (USA), SIN (Switzerland), and TRIUMF (Canada) and have been planned for use at new meson facilities under construction (USSR) and at proposed dedicated medical facilities. Providing therapeutically useful dose rates of pions requires a knowledge of the pion production cross sections as a function of primary proton energy (500 to 1000 MeV), pion energy (less than or equal to100 MeV), production angle, and target material… more
Date: January 1, 1985
Creator: Bradbury, J.N.
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Partner: UNT Libraries Government Documents Department
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Fossil energy program. Progress report, July 1980

Description: This report - the seventy-second of a series - is a compendium of monthly progress reports for the ORNL research and development programs that are in support of the increased utilization of coal and other fossil fuel alternatives to oil and gas as sources of clean energy. The projects reported this month include those for coal conversion development, chemical research and development, materials technology, component development and process evaluation, technical support to major liquefaction pro… more
Date: October 1, 1980
Creator: McNeese, L. E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Publications of Los Alamos research 1980

Description: This bibliography is a compilation of unclassified publications of work done at the Los Alamos National Laboratory for 1980. Papers published in 1980 are included regardless of when they were actually written. Publications received too late for inclusion in earlier compilations have also been listed. Declassification of previously classified reports is considered to constitute publication. All classified issuances are omitted-even those papers, themselves unclassified, which were published only… more
Date: September 1, 1981
Creator: Salazar, C. A. & Willis, J. K. (comps.)
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Publications in biomedical and environmental sciences programs, 1981

Description: This bibliography contains 698 references to articles in journals, books, and reports published in the subject area of biomedical and environmental sciences during 1981. There are 520 references to articles published in journals and books and 178 references to reports. Staff members in the Biomedical and Environmental Sciences divisions have other publications not included in this bibliography; for example, theses, book reviews, abstracts published in journals or symposia proceedings, pending j… more
Date: July 1, 1982
Creator: Moody, J.B. (comp.)
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Imaging using accelerated heavy ions

Description: Several methods for imaging using accelerated heavy ion beams are being investigated at Lawrence Berkeley Laboratory. Using the HILAC (Heavy-Ion Linear Accelerator) as an injector, the Bevalac can accelerate fully stripped atomic nuclei from carbon (Z = 6) to krypton (Z = 34), and partly stripped ions up to uranium (Z = 92). Radiographic studies to date have been conducted with helium (from 184-inch cyclotron), carbon, oxygen, and neon beams. Useful ranges in tissue of 40 cm or more are availab… more
Date: May 1, 1982
Creator: Chu, W.T.
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Partner: UNT Libraries Government Documents Department
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Health and Environmental Research: summary of accomplishments. Volume 2

Description: This is an account of some of the accomplishments of the health and environmental research program performed in national laboratories, universities, and research institutes. Both direct and indirect societal benefits emerged from the new knowledge provided by the health and environmental research program. In many cases, the private sector took this knowledge and applied it well beyond the mission of supporting the defense and energy needs of the Nation. Industrial and medical applications, for … more
Date: August 1, 1986
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Proceedings of clinical SPECT (single photon emission computed tomography) symposium

Description: It has been five years since the last in-depth American College of Nuclear Physicians/Society of Nuclear Medicine Symposium on the subject of single photon emission computed tomography (SPECT) was held. Because this subject was nominated as the single most desired topic we have selected SPECT imaging as the basis for this year's program. The objectives of this symposium are to survey the progress of SPECT clinical applications that have taken place over the last five years and to provide practi… more
Date: September 1, 1986
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Nuclear data development and shield design for neutrons below 60 MeV

Description: A nuclear data library was created for medium-energy-neutron-transport calculations. The 60-group library includes P/sub 5/ cross sections in standard LASL format for H, B, C, N, O, Si, Fe, and W. The 60-group structure was chosen from a sensitivity analysis of a thick iron shield calculated with a 50-MeV deuteron-on-beryllium neutron source spectrum and a 121-group cross-section set. The library combines processed ENDF/B-IV cross-section data below 20 MeV and higher-energy cross-section parame… more
Date: February 1, 1978
Creator: Wilson, W.B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Evaluation of the distribution of absorbed dose in child phantoms exposed to diagnostic medical x rays

Description: The purpose of this study was to determine, by theoretical calculation and experimental measurement, the absorbed dose distributions in two heterogeneous phantoms representing one-year- and five-year-old children from typical radiographic examinations for those ages. Theoretical work included the modification of an existing internal dose code which uses Monte Carlo methods to determine doses within the Snyder-Fisher mathematical phantom. A Ge(Li) detector and a pinhole collimator were used to m… more
Date: April 1, 1978
Creator: Chen, W. L.; Poston, J. W. & Warner, G. G.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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In Vivo Measurement of Cadmium in an Occupationally-Exposed Population

Description: Exposure to cadmium is recognized as a potentially serious health problem. A number of clinical abnormalities have been observed in workers occupationally exposed to cadmium. Therefore, it is essential that accurate data on body burdens be available in order to formulate dose-response relationships in man. The present Brookhaven facility for in vivo measurements of cadmium in man is described, and recent results from a field study to a cadmium production plant are reported. The cadmium content … more
Date: 1980~
Creator: Ellis, K. J.; Morgan, W. D.; Yasumura, S.; Vartsky, D.; Zanzi, I. & Cohn, S. H.
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Partner: UNT Libraries Government Documents Department
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