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An Assay Method for Determining Extra-Cellular Lipases from Pseudomonas aeruginosa

Description: The applicability of an isotopically labelled assay system to determine the lipase production in Pseudomonas aeruginosa was evaluated. Supernatant from cultures of Pseudomonas aeruginosa grown in a medium containing olive oil was incubated with a substrate containing labelled trioleate. Fatty acids were isolated by means of a liquid-liquid partition system. Enzyme activity was determined by measuring the amounts of free fatty acid by liquid scintillation counting. Findings indicate that the iso… more
Date: May 1978
Creator: Christensen, John N.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Coelomic Fluid Protein Profile in Earthworms Following Bacterial Challenge.

Description: Proteomic techniques were used to evaluate the protein profile of the earthworm, (Lumbricus terrestris), following a bacterial challenge. One control group received no injection; a second control group received injections of phosphate buffer solution (PBS). The experimental group received injections of PBS containing (Aeromonas hydrophila). After incubation for 12 hours at 20°C, coelomic fluid was collected from each group for analysis by 2-D electrophoresis. There were significant differences… more
Date: December 2006
Creator: Brooks, Geoffrey Lance
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Development of Cardiovascular Regulation in Embryos of the Domestic Fowl (Gallus Gallus), with a Partial Comparison to Embryos of the Desert Tortoise (Gopherus Agassizii)

Description: In adult vertebrates, cardiovascular regulation is accomplished by numerous systems with neural, hormonal and local components responsible for the majority of regulation. These regulatory components work in concert to maintain the essential function of blood perfusion to adult tissues. Given the essential nature of this function it is therefore surprising that the development of cardiovascular regulation during gestation is poorly understood. The majority of what is known is based on a single v… more
Date: August 1999
Creator: Crossley, Dane Alan
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Modulation of the Coelomic Fluid Protein Profile in the Earthworm, Lumbricus Terrestris, After Exposure to Copper as Copper Sulfate

Description: Proteomic techniques were used to analyze the protein profile of earthworm, Lumbricus terrestris, coelomic fluid collected by either whole body dissection method or the coelomic cavity puncture method. Data demonstrated that collection of coelomic fluid using the coelomic cavity puncture method protocol resulted in a 32% reduction, 377 +/- 4.5 vs 253+/- 19.9 (p=0.0007), in the number of individual proteins. It was determined that the coelomic cavity puncture method yielded a "cleaner" preparati… more
Date: May 2010
Creator: Herring, Reese
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Autonomic Control of Heat Rate Variability in Emu (Dromaius novaehollandiae) Hatchlings

Description: Thesis written by a student in the UNT Honors College discussing the role of the autonomic nervous system in the heart rate variability of day-old emu hatchlings. Atropine and propranolol were administered to block the action of cholinegric and adrenegric pathways and thereby reduce heart rate.
Date: Autumn 2002
Creator: Motiwala, Rajesh
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Honors College
open access

Unique applications of cultured neuronal networks in pharmacology, toxicology, and basic neuroscience

Description: This dissertation research explored the capabilities of neuronal networks grown on substrate integrated microelectrode arrays in vitro with emphasis on utilizing such preparations in three specific application domains: pharmacology and drug development, biosensors and neurotoxicology, and the study of burst and synaptic mechanisms. Chapter 1 details the testing of seven novel AChE inhibitors, demonstrating that neuronal networks rapidly detect small molecular differences in closely related comp… more
Date: May 2001
Creator: Keefer, Edward W.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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The aquatic insect communities of Holbrook Creek and Cochetopa Creek in Colorado.

Description: The first objective for this problem in lieu of thesis project was to gather, identify to the lowest practical taxonomic level and organize all available aquatic insects collected from high altitude Colorado aquatic systems during the summers of 1994, 1996, 1998, and 2002 for the University of North Texas Environmental Science Field Course (BIOL 5650). The curated collection will be housed in the Elm Fork Natural History Museum, located at the University of North Texas. The second objective was… more
Date: December 2003
Creator: Wallace, Mark Allen
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries

Influence of Hypoxia on Acute Lead Toxicity and Calcium Homeostasis in Early Life Stage Zebrafish (Danio rerio)

Description: The purpose of this study was to investigate the effects of Pb and hypoxia co-exposure on Pb toxicity and Ca homeostasis in early life stage (ELS) zebrafish (Danio rerio). Previous evidence indicates that exposure of ELS zebrafish to hypoxia (~20% air saturation) reduces Ca uptake, likely through down-regulation of the apical epithelial Ca channel (ECaC). Considering that Pb and Ca are known antagonists and compete for uptake pathways, it was hypothesized that co-exposure of Pb with hypoxia wou… more
Date: December 2021
Creator: Moghimi, Mehrnaz
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries

A Multimedia Atlas of Dissection for Comparative Anatomy of the Vertebrates

Description: Traditional methods of teaching the laboratory course for Comparative Anatomy of the Vertebrates could be improved by applying current computer technology to construct an interactive, multimedial atlas of dissection. Five specimens used in comparative anatomy courses at most institutions were chosen as representative members of the Phylum Chordata: amphioxus, lamprey, dogfish shark, mud puppy, and cat. Specimens were dissected according to the modified method of Wischnitzer, 1993, and each stag… more
Access: Restricted to UNT Community Members. Login required if off-campus.
Date: August 1999
Creator: Curran, Anthony A.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Studies on Zebrafish Thrombocyte Function

Description: Thrombocytes are important players in hemostasis. There is still much to be explored regarding the molecular basis of the thrombocyte function. In our previous microarray analysis data, we found IFT122 (an intraflagellar transport protein known to be involved in cilia formation) transcripts in zebrafish thrombocytes. Given recent discoveries of non-ciliary roles for IFTs, we examined the possibility that IFT122 affects thrombocyte function. We studied the role of IFT122 in thrombocyte function.… more
Date: May 2017
Creator: Pulipakkam Radhakrishnan, Uvaraj
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Neurotoxicity of the Industrial Solvent 4-Methylcyclohexanemethanol: Involvement of the GABA Receptor

Description: A recent chemical spill of 4-Methylcyclohexanemethanol (4-MCHM) in West Virginia left 300,000 people without water. Officials claimed that this compound is not lethally toxic, but potentially harmful if swallowed or inhaled, and can cause eye and skin irritation. Sittig's Handbook of Toxic and Hazardous Chemical Carcinogens reports high exposures from skin contact or inhalation may cause damage to the heart, liver, kidneys, and lungs, and may result in death. However, no quantitative data seem… more
Date: May 2015
Creator: Gibson, Jason (Jason Robert)
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Implications of Diet in Cardiovascular Disease Risk: Postprandial Changes in Circulating Monocytes and Endotoxemia

Description: It is well established that continual consumption of a diet high in fat leads to the development of chronic conditions such as obesity, cardio metabolic syndrome, and atherosclerosis that are associated with high incidence of cardiovascular disease. Recent studies have identified endotoxin-derived inflammation as a major diving force for the development of these conditions. Our laboratory has recently demonstrated that consumption of a single high-fat meal results in acute postprandial endotoxe… more
Date: August 2018
Creator: Venable, Andrea Henning
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Beta-adrenergic Blockade Via Atenolol and Its Effects on Blood Pressure, Heart Rate, and Renal Morphology in the Developing Chicken Gallus Gallus Domesticus

Description: Chicken embryos were chronically exposed to the ?1- blocker atenolol during one of three stages: mesonephros (E7-E9), mesonephros-metanephros (E11-E13), or metanephros (E15-E17). Mesonephros group hearts were larger than all other groups (P < 0.01). Mesonephros and metanephros group kidneys were larger than all remaining groups (P < 0.0001). The mesonephros group nephron number was ~40% lower than control values (P = 0.002). Glomerular areas were 26% and 18% larger than the control group in the… more
Date: December 2012
Creator: Rossitto Lopez, Josie Jovita
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Chronic Hypoxia and Hyperoxia Modifies Morphology and Vegf Expression of the Lungs of the Developing Chicken (Gallus Gallus Domesticus)

Description: This study determines effects of oxygen levels on morphology and VEGF expression of developing chicken lungs following incubation in normoxia (21% O2), hypoxia (15% O2) or hyperoxia (30% O2), until developmental days 16 or 18. Lung morphology was assessed using light microscopy, while VEGF expression was determined with ELISA. In hypoxia, the proportion of parabronchial tissue and parabronchi including lumina increased from day 16 to 18 (61 to 68% and 74.2 to 82.2%, respectively). Non-parabronc… more
Date: December 2012
Creator: Lewallen, Melissa Anjanette
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Resistance Exercise and Alcohol: Combined Effects on Physiology and Performance

Description: Resistance exercise (RE) training is a well-known and effective method for promoting increases in muscle mass and strength. A single bout of RE induces physiological disturbances that require coordinated activation of the immune system and intramuscular signaling in order to return the tissue to homeostasis and adapt to the RE challenge. On the other hand, acute binge alcohol consumption can affect the immune response to an inflammatory challenge, intramuscular anabolic signaling, and muscle pr… more
Date: August 2018
Creator: Levitt, Danielle E.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Glucose and Altered Ceramide Biosynthesis Impact the Transcriptome and the Lipidome of Caenorhabditis elegans

Description: The worldwide rise of diabetes and obesity has spurred research investigating the molecular mechanisms that mediate the deleterious effects associated with these diseases. Individuals with diabetes and/or obesity are at increased risk from a variety of health consequences, including heart attack, stroke and peripheral vascular disease; all of these complications have oxygen deprivation as the central component of their pathology. The nematode Caenorhabditis elegans has been established as a mod… more
Date: August 2016
Creator: Ladage, Mary Lee
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries

Application of Cultured Neuronal Networks for Use as Biological Sensors in Water Toxicology and Lipid Signaling.

Description: This dissertation research explored the capabilities of neuronal networks grown on substrate integrated microelectrode arrays in vitro to be applied to toxicological research and lipid signaling. Chapter 1 details the effects of chlorine on neuronal network spontaneous electrical activity and pharmacological sensitivity. This study demonstrates that neuronal networks can maintain baseline spontaneous activity, and respond normally to pharmacological manipulations in the present of three times… more
Access: Restricted to the UNT Community Members at a UNT Libraries Location.
Date: August 2004
Creator: Dian, Emese Emöke
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Examination of the Relationship Between Glucuronic Acid and Vascular Damage in Rats

Description: The goal of this experiment was to examine the role of glucuronic acid in the development of vascular damage in the kidneys and retinas of diabetic individuals. Glucuronic acid was provided to rats in their water at various concentrations in order to increase plasma levels of the compound. Kidneys and retinas were excised and compared to control specimens using microscopy to determine the effect of elevated blood glucuronic acid levels on the occurrence of microaneurysms in renal capillary netw… more
Date: May 2013
Creator: Moore, Ryan
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Classification of Toolmark Surfaces on Zipper Teeth

Description: This study proposes the classification of the toolmark under the heads of zipper teeth as a subclass characteristic as outlined by the Association of Firearm and Toolmark Examiners (AFTE). Two separate cases in which zipper teeth were found at crime scenes prompted this study. Brass zipper teeth manufactured by YKK were taken from 20 pairs of jeans and studied using a Reichert comparison microscope at 4X power. Photographs were taken and over 750 comparisons made. It was found that the toolmark… more
Date: December 1999
Creator: Jacobsen, Dawn
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Women Have Higher Skin Temperature on the Back during Treadmill Exercise in a Hot, Humid Environment

Description: A common measurement of body temperature during exercise in a hot, humid environment is mean skin temperature collected from 3-12 sites on the body. However, such an approach fails to demonstrate localized differences in skin temperature that are likely to exist as a function of gender. The purpose of this study was to examine potential differences in skin temperature between men and women at 17 different locations on the body. Young women (21 ± 1 y; n = 11) and men (23 ± 3; n = 10) were recrui… more
Date: August 2014
Creator: Venable, Adam Steven
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries

Phenotype Analysis of the CISD Gene Family Relative to Mitochondrial Function in Caenorhabditis elegans

Description: NEET proteins belong to a unique class of [2Fe-2S] cluster proteins that have been shown to participate in various biological processes such as regulating iron, reactive oxygen species and apoptosis within the cell and are localized to the mitochondria. Disruption of the mitochondrial NEET proteins are associated with different human diseases such as obesity, neurodegeneration, cancer and diabetes. In humans, a missense mutation in the CISD2 gene results in a heritable multisystem disorder term… more
Access: Restricted to UNT Community Members. Login required if off-campus.
Date: December 2019
Creator: Mungwira, Chipo F
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Linkage Relationships of Greenbug Resistance in Barley, Hordeum Vulgare L.

Description: The linkage relationship and arm location of the gene for greenbug resistance in the variety Will was determined by using primary trisonomics and tertiary trisomic homozygous translocations. The gene for greenbug resistance was found to be on linkage group 1 by using primary trisonomics. The gene was located on the cetromere segment of the Tl-6a translocation by using a tertiary trismoic homozygous for greenbug resistance. The data further substantiates the feasibility of using trisomics in pla… more
Date: December 1972
Creator: Gardenhire, James H.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Obligately Thermophilic Nitrogen-Fixation in Some Soil Bacteria

Description: In the work presented here, it is claimed that bacteria have been isolated which are capable of growth at high temperatures utilizing molecular nitrogen as their sole nitrogen source. Soil bacteria were isolated which grew at 55 C in nitrogen-free media. They were found to be obligatory thermophiles in nitrogen-free media and facultative thermophiles in media containing organically bound nitrogen.
Date: August 1971
Creator: Milam, Mary
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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