[Chemistry]

[Chemistry]

Date: unknown
Creator: unknown
Description: Photograph of two student mixing chemicals in a chemistry class. The male student is pouring liquid from a graduated cylinder into a round bottom flask, while the female student is using a pipette to pour liquid into a bottle. They are surrounded by chemistry lab material and are wearing protective aprons.
Contributing Partner: UNT Libraries Special Collections
Technetium chemistry

Technetium chemistry

Date: April 1996
Creator: Burns, C.; Bryan, J.; Cotton, F.; Ott, K.; Kubas, G.; Haefner, S. et al.
Description: Technetium chemistry is a young and developing field. Despite the limited knowledge of its chemistry, technetium is the workhorse for nuclear medicine. Technetium is also a significant environmental concern because it is formed as a byproduct of nuclear weapons production and fission-power generators. Development of new technetium radio-pharmaceuticals and effective environmental control depends strongly upon knowledge of basic technetium chemistry. The authors performed research into the basic coordination and organometallic chemistry of technetium and used this knowledge to address nuclear medicine and environmental applications. This is the final report of a three-year Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL).
Contributing Partner: UNT Libraries Government Documents Department
CLOUD CHEMISTRY.

CLOUD CHEMISTRY.

Date: March 2001
Creator: Schwartz, S. E.
Description: Clouds present substantial concentrations of liquid-phase water, which can potentially serve as a medium for dissolution and reaction of atmospheric gases. The important precursors of acid deposition, SO{sub 2} and nitrogen oxides NO and NO{sub 2} are only sparingly soluble in clouds without further oxidation to sulfuric and nitric acids. In the case of SO{sub 2} aqueous-phase reaction with hydrogen peroxide, and to lesser extent ozone, are identified as important processes leading to this oxidation, and methods have been described by which to evaluate the rates of these reactions. The limited solubility of the nitrogen oxides precludes significant aqueous-phase reaction of these species, but gas-phase reactions in clouds can be important especially at night.
Contributing Partner: UNT Libraries Government Documents Department
PEROXYNITRITE CHEMISTRY

PEROXYNITRITE CHEMISTRY

Date: November 29, 2000
Creator: Lymar, S. V.
Description: This century old area of research has been experiencing a renaissance during the last decade, with the annual number of publications on the subject increasing from only one in 1990 to nearly 200 in the late-1990s. This renewed interest is stimulated by the discovery of biological roles of nitric oxide, distinguished by the 1998 Nobel prize, and the recognition that the conversion of nitric oxide into peroxynitrite may play major roles in human diseases associated with oxidative stress and in cellular defense against invading pathogens. Peroxynitrite (ONOO{sup {minus}})is a structural isomer of nitrate (NO{sub 3}{sup {minus}}) that contains a peroxo bond. The physiological route to ONOO{sup {minus}} is provided by the combination of nitric oxide ({center_dot}NO) with superoxide ({center_dot}O{sub 2}{sup {minus}}), an extremely rapid reaction occurring upon every encounter of these radicals (the upper dot denotes radical species). Both {center_dot}NO and {center_dot}O{sub 2}{sup {minus}} are the oxygen metabolic products simultaneously generated in a number of cell types within a human body. Compared to its precursors, peroxynitrite is a much stronger oxidant capable of oxidizing proteins, nucleic acids, and lipids.
Contributing Partner: UNT Libraries Government Documents Department
Metals in Chemistry and Biology: Computational Chemistry Studies

Metals in Chemistry and Biology: Computational Chemistry Studies

Date: May 2007
Creator: Dinescu, Adriana
Description: Numerous enzymatic reactions are controlled by the chemistry of metallic ions. This dissertation investigates the electronic properties of three transition metal (copper, chromium, and nickel) complexes and describes modeling studies performed on glutathione synthetase. (1) Copper nitrene complexes were computationally characterized, as these complexes have yet to be experimentally isolated. (2) Multireference calculations were carried out on a symmetric C2v chromium dimer derived from the crystal structure of the [(tBu3SiO)Cr(µ-OSitBu3)]2 complex. (3) The T-shaped geometry of a three-coordinate β-diketiminate nickel(I) complex with a CO ligand was compared and contrasted with isoelectronic and isosteric copper(II) complexes. (4) Glutathione synthetase (GS), an enzyme that belongs to the ATP-grasp superfamily, catalyzes the (Mg, ATP)-dependent biosynthesis of glutathione (GSH) from γ-glutamylcysteine and glycine. The free and reactant forms of human GS (wild-type and glycine mutants) were modeled computationally by employing molecular dynamics simulations, as these currently have not been structurally characterized.
Contributing Partner: UNT Libraries
[Chemistry Society, 1942]

[Chemistry Society, 1942]

Date: 1942
Creator: unknown
Description: Photograph of the chemistry society posing in front of the entrance of a building in the 1940's.
Contributing Partner: UNT Libraries Special Collections
[Chemistry Students in Lab]

[Chemistry Students in Lab]

Date: unknown
Creator: unknown
Description: Photograph of two male students studying chemicals in a laboratory. One student is sitting on a stool holding a test tube as the other student stands and watches.
Contributing Partner: UNT Libraries Special Collections
[Chemistry lab / robotics / forensics]

[Chemistry lab / robotics / forensics]

Date: January 22, 1994
Creator: Center for Media Production
Description: Video footage of students and faculty at the University of North Texas working in biology, robotics, and forensics labs.
Contributing Partner: UNT Libraries Special Collections
Isomerization Reactions in Organosilicon Chemistry

Isomerization Reactions in Organosilicon Chemistry

Date: August 1985
Creator: Kwak, Young-Woo
Description: None
Contributing Partner: UNT Libraries
Algorithmic Strategies in Combinatorial Chemistry

Algorithmic Strategies in Combinatorial Chemistry

Date: August 1, 2000
Creator: GOLDMAN,DEBORAH; ISTRAIL,SORIN; LANCIA,GIUSEPPE; PICCOLBONI,ANTONIO & WALENZ,BRIAN
Description: Combinatorial Chemistry is a powerful new technology in drug design and molecular recognition. It is a wet-laboratory methodology aimed at ``massively parallel'' screening of chemical compounds for the discovery of compounds that have a certain biological activity. The power of the method comes from the interaction between experimental design and computational modeling. Principles of ``rational'' drug design are used in the construction of combinatorial libraries to speed up the discovery of lead compounds with the desired biological activity. This paper presents algorithms, software development and computational complexity analysis for problems arising in the design of combinatorial libraries for drug discovery. The authors provide exact polynomial time algorithms and intractability results for several Inverse Problems-formulated as (chemical) graph reconstruction problems-related to the design of combinatorial libraries. These are the first rigorous algorithmic results in the literature. The authors also present results provided by the combinatorial chemistry software package OCOTILLO for combinatorial peptide design using real data libraries. The package provides exact solutions for general inverse problems based on shortest-path topological indices. The results are superior both in accuracy and computing time to the best software reports published in the literature. For 5-peptoid design, the computation is rigorously reduced to an exhaustive ...
Contributing Partner: UNT Libraries Government Documents Department
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