Fluoride-Induced Changes in In Vivo Papillary Cyclic AMP
Description:
Two separate experiments were designed to measure urinary cyclic AMP and renal papillary cyclic AMP, respectively, Results suggest that urinary cyclic AMP excretion rate is unchanged and cannot be used as an index of tubular sensitivity to either vasopressin or fluoride. However, renal papillary tissue cyclic AMP increased significantly (p<0.05) at plasma fluoride concentrations which result in polyuric renal failure. Further, it appears that fluoride independently stimulates cyclic AMP in the …
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Date:
December 1982
Creator:
Maxwell, Jack Allen
Partner:
UNT Libraries