Identification of functional information subgraphs in cultured neural networks

Identification of functional information subgraphs in cultured neural networks

Date: July 13, 2009
Creator: Gintautas, Vadas; Bettencourt, Luis & Ham, Michael I.
Description: This paper accompanies an oral presentation on the identification of functional information subgraphs in cultured neural networks.
Contributing Partner: UNT College of Arts and Sciences
Concentration-dependent Effects of D-Methylphenidate on Frontal Cortex and Spinal Cord Networks in vitro

Concentration-dependent Effects of D-Methylphenidate on Frontal Cortex and Spinal Cord Networks in vitro

Date: December 2004
Creator: Miller, Benjamin R.
Description: Spontaneously active frontal cortex and spinal cord networks grown on microelectrode arrays were used to study effects of D-methylphenidate. These central nervous system tissues have relatively low concentrations of dopaminergic and noradrenergic neurons compared to the richly populated loci, yet exhibit similar neurophysiological responses to methylphenidate. The spontaneous spike activity of both tissues was inhibited in a concentration-dependent manner by serial additions of 1-500 µM methylphenidate. Methylphenidate is non-toxic as spike inhibition was recovered following washes. The average concentrations for 50% spike rate inhibition (IC50 ± SD) were 118 ± 52 (n= 6) and 57 ± 43 (n = 11) for frontal cortex and spinal cord networks, respectively. A 3 hour exposure of a network to 1 mM methylphenidate was nontoxic. The effective concentrations described in this study are within the therapeutic dosage range. Therefore, the platform may be used for further investigations of drug mechanisms.
Contributing Partner: UNT Libraries
Problems Associated with the Estimation of Nerve Cell Densities in Cultured Neuronal Networks

Problems Associated with the Estimation of Nerve Cell Densities in Cultured Neuronal Networks

Date: Spring 2007
Creator: Pankonien, J. Blake
Description: Thesis written by a student in the UNT Honors College discussing the problems and variables associated with assessing the total number of neurons in a network from cell seeding concentrations and measurements of network area.
Contributing Partner: UNT Honors College
An in vitro model for testing drugs to treat tinnitus

An in vitro model for testing drugs to treat tinnitus

Date: October 2011
Creator: Wu, Calvin; Gopal, Kamakshi V.; Gross, Guenter W.; Lukas, Thomas J. & Moore, Ernest J.
Description: Article discussing an in vitro model for testing drugs to treat tinnitus.
Contributing Partner: UNT College of Arts and Sciences
Optimization of Cell Culture Procedures for Growing Neural Networks on Microelectrode Arrays

Optimization of Cell Culture Procedures for Growing Neural Networks on Microelectrode Arrays

Date: December 2007
Creator: Santa Maria, Cara L.
Description: This thesis describes the development of an optimized method for culturing dissociated, monolayer neuronal networks from murine frontal cortex and midbrain. It is presented as a guidebook for use by cell culture specialists and laboratory personnel who require updated and complete procedures for use with microelectrode array (MEA) recording technology. Specific cell culture protocols, contamination prevention and control, as well common problems encountered within the cell culture facility, are discussed. This volume offers value and utility to the rapidly expanding fields of MEA recording and neuronal cell culture. Due to increasing interest in determining the mechanisms underlying Parkinson's disease, the newly developed procedures for mesencephalon isolation and culture on MEAs are an important research contribution.
Contributing Partner: UNT Libraries
Determining Properties of Synaptic Structure in a Neural Network through Spike Train Analysis

Determining Properties of Synaptic Structure in a Neural Network through Spike Train Analysis

Date: May 2007
Creator: Brooks, Evan
Description: A "complex" system typically has a relatively large number of dynamically interacting components and tends to exhibit emergent behavior that cannot be explained by analyzing each component separately. A biological neural network is one example of such a system. A multi-agent model of such a network is developed to study the relationships between a network's structure and its spike train output. Using this model, inferences are made about the synaptic structure of networks through cluster analysis of spike train summary statistics A complexity measure for the network structure is also presented which has a one-to-one correspondence with the standard time series complexity measure sample entropy.
Contributing Partner: UNT Libraries
Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition

Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition

Date: February 15, 2014
Creator: Wu, Calvin; Gopal, Kamakshi V.; Moore, Ernest J. & Gross, Guenter W.
Description: Article on antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition.
Contributing Partner: UNT College of Arts and Sciences
Pharmacodynamics of potassium channel openers in cultured neuronal networks

Pharmacodynamics of potassium channel openers in cultured neuronal networks

Date: June 5, 2014
Creator: Wu, Calvin; Gopal, Kamakshi V.; Lukas, Thomas J.; Gross, Guenter W. & Moore, Ernest J.
Description: Article discussing pharmacodynamics of potassium channel openers in cultured neuronal networks.
Contributing Partner: UNT College of Arts and Sciences
Towards the timely detection of toxicants

Towards the timely detection of toxicants

Date: April 2004
Creator: Ignaccolo, Massimiliano; Grigolini, Paolo & Gross, Guenter W.
Description: Article discussing the problem of enhancing the sensitivity of biosensors to the influence of toxicants, with an entropy method of analysis, denoted as CASSANDRA, for the specific purpose of studying non-stationary time series.
Contributing Partner: UNT College of Arts and Sciences
Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks

Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks

Date: May 24, 2011
Creator: Gopal, Kamakshi V.; Wu, Calvin; Moore, Ernest J. & Gross, Guenter W.
Description: Article on the assessment of styrene oxide neurotoxicity using in vitro auditory cortex networks.
Contributing Partner: UNT College of Arts and Sciences
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