Cardiac and metabolic physiology of early larval zebrafish (Danio rerio) reflects parental swimming stamina
Date: February 24, 2012
Creator: Gore, Matthew & Burggren, Warren W.
Description: This article discusses cardiac and metabolic physiology of early larval zebrafish (Danio rerio) reflecting parental swimming stamina. Abstract: Swimming stamina in adult fish is heritable, it is unknown if inherited traits that support enhanced swimming stamina in offspring appear only in juveniles and/or adults, or if these traits actually appear earlier in the morphologically quite different larvae. To answer this question, mature adult zebrafish (Danio rerio) were subjected to a swimming performance test that allowed separation into low swimming stamina or high swimming stamina groups. Adults were then bred within their own performance groups. Larval offspring from each of the two groups, designated high (L(HSD)) and low stamina-derived larvae (L(LSD)), were then reared at 27°C in aerated water (21% O(2)). Routine (f(H),r) and active (f(H),a) heart rate, and routine [Formula: see text] and active [Formula: see text] mass-specific oxygen consumption were recorded from 5 days post fertilization (dpf) through 21 dpf, and gross cost of transport and factorial aerobic metabolic scope were derived from [Formula: see text] measurements. Heart rate generally ranged between 150 and 225 bpm in both L(HSD) and L(LSD) populations. However, significant (P<0.05) differences existed between the L(LSD) and L(HSD) populations at 5 and 14 dpf in ...
Contributing Partner: UNT College of Arts and Sciences
Permallink:digital.library.unt.edu/ark:/67531/metadc115198/
Role of Hypoxia in the Evolution and Development of the Cardiovascular System
Date: 2007
Creator: Fisher, Steven A. & Burggren, Warren W.
Description: This article discusses the role of hypoxia in the evolution and development of the cardiovascular system. How multicellular organisms obtain and use oxygen and other substrates has evolved over hundreds of millions of years in parallel with the evolution of oxygen-delivery systems. A steady supply of oxygen is critical to the existence of organisms that depend on oxygen as a primary source of fuel (i.e., those that live by aerobic metabolism). Not surprisingly, a number of mechanisms have evolved to defend against oxygen deprivation. This review highlights evolutionary and developmental aspects of O(2) delivery to allow understanding of adaptive responses to O(2) deprivation (hypoxia). First, the authors consider how the drive for more efficient oxygen delivery from the heart to the periphery may have shaped the evolution of the cardiovascular system, with particular attention to the routing of oxygenated and deoxygenated blood in the cardiac outlet. Then the authors consider the role of O(2) in the morphogenesis and the cardiovascular system of animals of increasing size and complexity. The authors conclude by suggesting areas for future research regarding the role of oxygen deprivation and oxidative stress in the normal development of the heart and vascular or in the pathogenesis of ...
Contributing Partner: UNT College of Arts and Sciences
Permallink:digital.library.unt.edu/ark:/67531/metadc115191/
Comparative Assessment of Peer Review: Project Outcomes Report
Date: January 2013
Creator: Frodeman, Robert; Holbrook, J. Britt; Moen, William E.; Burggren, Warren W. & Mitcham, Carl
Description: This report discusses the Comparative Assessment of Peer Review (CAPR) project outcomes. Public funding agencies are required to demonstrate accountability to their government funders (e.g., Congress) as well as to the public. Some agencies - including the US National Science Foundation (NSF) - have used broader societal impacts criteria as part of the review process of grant proposals in order to connect scientific research to societal needs. But these agencies have often encountered questions from scientists and engineers for how to integrate such demands for broader societal impacts into their research proposals. In an effort to help clarify the idea of broader impacts, in 2010 NSF and Congress proposed a list of national needs that NSF-funded research would be required to meet. But was this the best solution? This report discusses the authors' research.
Contributing Partner: UNT College of Arts and Sciences
Permallink:digital.library.unt.edu/ark:/67531/metadc139466/