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Impact of Radiation Biology on Fundamental in Biology
Research supported by OHER and its predecessors has as one of its major goals an understanding of the effects of radiation at low doses and dose rates on biological systems, so as to predict their effects on humans. It is not possible to measure such effects directly. They must be predicted from basic knowledge on how radiation affects cellular components such as DNA and membranes and how cells react to such changes. What is the probability of radiation producing human mutations and what are the probabilities of radiation producing cancer? The end results of such studies are radiation exposure standards for workers and for the general population. An extension of these goals is setting standards for exposure to chemicals involved in various energy technologies. This latter problem is much more difficult because chemical dosimetry is is a primitive state compared to radiation dosimetry.
Homosexuality and biology
Xerographic copy of an Atlantic Monthly article introducing scientific research on sexual orientation.
6th Annual Systems Biology Symposium: Systems Biology and the Environment
Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology is an annual two-day event gathering the most influential researchers transforming biology into an integrative discipline investigating complex systems. In recognition of the fundamental similarity between the scientific problems addressed in environmental science and systems biology studies at the molecular, cellular, and organismal levels, the 2007 Symposium featured global leaders in “Systems Biology and the Environment.” The objective of the 2007 “Systems Biology and the Environment” International Symposium was to stimulate interdisciplinary thinking and research that spans systems biology and environmental science. This Symposium was well aligned with the DOE’s Genomics:GTL program efforts to achieve scientific objectives for each of the three DOE missions: • Develop biofuels as a major secure energy source for this century, • Develop biological solutions for intractable environmental problems, and • Understand biosystems’ climate impacts and assess sequestration strategies Our scientific program highlighted world-class research exemplifying these priorities. The Symposium featured 45 minute lectures from 12 researchers including: Penny/Sallie Chisholm of MIT gave the keynote address “Tiny Cells, Global Impact: What Prochlorococcus Can Teach Us About Systems Biology”, plus Jim Fredrickson of PNNL, Nitin Baliga of ISB, Steve Briggs of UCSD, David Cox of Perlegen Sciences, Antoine Danchin of Institut Pasteur, John Delaney of the U of Washington, John Groopman of Johns Hopkins, Ben Kerr of the U of Washington, Steve Koonin of BP, Elliott Meyerowitz of Caltech, and Ed Rubin of LBNL. The 2007 Symposium promoted DOE’s three mission areas among scientists from multiple disciplines representing academia, non-profit research institutions, and the private sector. As in all previous Symposia, we had excellent attendance of participants representing 20-30 academic or research-oriented facilities along with 25-30 private corporations from 5-10 countries. To broaden the audience for …
[Exterior view of the Biology Building]
Photograph of an exterior view of the Biology Building, 1995.
7th Annual Systems Biology Symposium: Systems Biology and Engineering
Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology has been hosted by the Institute for Systems Biology in Seattle, Washington, since 2002. The annual two-day event gathers the most influential researchers transforming biology into an integrative discipline investingating complex systems. Engineering and application of new technology is a central element of systems biology. Genome-scale, or very small-scale, biological questions drive the enigneering of new technologies, which enable new modes of experimentation and computational analysis, leading to new biological insights and questions. Concepts and analytical methods in engineering are now finding direct applications in biology. Therefore, the 2008 Symposium, funded in partnership with the Department of Energy, featured global leaders in "Systems Biology and Engineering."
Integrating Concepts in Modern Molecular Biology into a High School Biology Curriculum
More so than any other science in the past several decades, Biology has seen an explosion of new information and monumental discoveries that have had a profound impact on much more than the science itself. Much of this has occurred at the molecular level. Many of these modern concepts, ideas, and technologies, as well as their historical context, can be easily understood and appreciated at the high school level. Moreover, it is argued here that the integration of this is critical for making biology relevant as a modern science. A contemporary high school biology curriculum should adequately reflect this newly acquired knowledge and how it has already has already begun to revolutionize medicine, agriculture, and the study of biology itself. This curriculum provides teachers with a detailed framework for integrating molecular biology into a high school biology curriculum. It is not intended to represent the curriculum for an entire academic year, but should be considered a significant component. In addition to examining key concepts and discoveries, it examines modern molecular techniques, their applications, and their relevance to science and beyond. It also provides several recommended labs and helpful protocols.
[Biology Building]
Photograph of the Biology Building on the North Texas campus. There are cars parked in front of and along the side of the building.
The Biology of Aging
No Description Available.
Third international congress of plant molecular biology: Molecular biology of plant growth and development
The Congress was held October 6-11, 1991 in Tucson with approximately 3000 scientists attending and over 300 oral presentations and 1800 posters. Plant molecular biology is one of the most rapidly developing areas of the biological sciences. Recent advances in the ability to isolate genes, to study their expression, and to create transgenic plants have had a major impact on our understanding of the many fundamental plant processes. In addition, new approaches have been created to improve plants for agricultural purposes. This is a book of presentation and posters from the conference.
A New Biology for the 21st Century; Ensuring the United States Leads the Coming Biology Revolution
In July, 2008, the National Institutes of Health (NIH), National Science Foundation (NSF), and Department of Energy (DOE) asked the National Research Council’s Board on Life Sciences to convene a committee to examine the current state of biological research in the United States and recommend how best to capitalize on recent technological and scientific advances that have allowed biologists to integrate biological research findings, collect and interpret vastly increased amounts of data, and predict the behavior of complex biological systems. From September 2008 through July of 2009, a committee of 16 experts from the fields of biology, engineering and computational science undertook to delineate those scientific and technological advances and come to a consensus on how the U.S. might best capitalize on them. This report, authored by the Committee on a New Biology for the 21st Century, describes the committee’s work and conclusions.
CaMV35S promoter – A plant biology and biotechnology workhorse in the era of synthetic biology
This review article calls for establishing the CaMV 35S promoter as a quantitative reference standard for transcription activity in plants.
[Students in biology class]
Photograph of five students in a biology class consisting of three women and two men. One woman is standing next to the biology table, the two men are sitting at each short end of the table, and the other two women are sitting next to each other in the middle of the table. The students sitting down each have their own microscopes, while the man sitting on the right looks through his and writes down on his paper. There are glass jars and more microscopes visible behind the students.
[Student in biology class]
Photograph of a student sitting in biology class with her microscope and test tubes resting on the table in front of her. She is holding a pencil as if she about to write on a sheet of paper.
[Dr. McBride, Biology]
Photograph of Dr. McBride of the Biology department. He poses in a suit and tie.
[Dr. McBride, Biology]
Photograph of Dr. McBride of the Biology department. He poses in a suit and tie.
Bomb Pulse Biology
No Description Available.
[Oven for biology in use]
Photograph of an oven made for the biology labs to heat vials of liquid and other mixtures. Over a dozen tubes are resting on racks inside of the wooden box and a small hot plate sits at the bottom. Two large machine hoses are connected to the inside.
[Biology Building entrance]
Photograph of the Biology Building exterior from across the street. There is a row of cars parked in front of the entrance and a bike is also parked next to it.
[Biology Department member]
Photograph of an unidentified member of the Biology Department. He is seated for a portrait photo and is wearing a suit with a thin bow tie and handkerchief.
[Band and Biology Lab]
A video of a jazz band rehearsal and students working in a science lab.
Neutron structural biology
This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). We investigated design concepts of neutron scattering capabilities for structural biology at spallation sources. This included the analysis of design parameters for protein crystallography as well as membrane diffraction instruments. These instruments are designed to be general user facilities and will be used by scientists from industry, universities, and other national laboratories.
Donnor Laboratory Semiannual Report -- Biology and Medicine: Fall 1964
No Description Available.
Systems Biology Knowledgebase for a New Era in Biology A Genomics:GTL Report from the May 2008 Workshop
Biology has entered a systems-science era with the goal to establish a predictive understanding of the mechanisms of cellular function and the interactions of biological systems with their environment and with each other. Vast amounts of data on the composition, physiology, and function of complex biological systems and their natural environments are emerging from new analytical technologies. Effectively exploiting these data requires developing a new generation of capabilities for analyzing and managing the information. By revealing the core principles and processes conserved in collective genomes across all biology and by enabling insights into the interplay between an organism's genotype and its environment, systems biology will allow scientific breakthroughs in our ability to project behaviors of natural systems and to manipulate and engineer managed systems. These breakthroughs will benefit Department of Energy (DOE) missions in energy security, climate protection, and environmental remediation.
Cambridge Healthtech Institute's Fourth Annual In silico Biology Conference "Modeling Systems Biology for Research and Target Prioritization"
In silico biology, the computer aided analysis of biological systems, is a relatively young research area. It first has been coined in the late 1990's and emerged from Theoretical and Computational Biology. As in other fields before, biology experiences an increased use of systems mathematics and computer simulation. With the human genome sequence available, with an exponentially growing number of completely sequenced genomes from various model organisms and with expression and proteomic data at hand, the research paradigm is shifted towards systems analysis and simulation. Computer aided modeling of complex biomolecules and assemblies are already routinely performed. Nowadays, theoretical description and computer simulation of cellular components in larger intra- and inter-cellular networks is of growing importance. Together with classic biological and clinical experiments as well as data from functional genomics, in silico biology will take the leading role in the analysis of biological systems.
Biology and Medicine Semiannual Report for October 1957 Through March 1958
Data are presented from the following studies: the radiation chemistry of pepsin, gelatin, methanol, benzene, and hexanes; the effects of irradiation of the pituitary in advanced cancer using high-energy particles from the 184-inch cyclotron; applications of ion beams in biological studies; the metabolism of strontium-90 and its relation to calcium metabolism in rats; hematological effects of low-level radiation doses in man; the influence of diet on serum lipoproteins; development of simplified methods for the analysis of blood serum for lipid content; tracer studies employing iron59 of red blood cell production and destruction and iron metabolism in a wide variety of blood disorders; tracer studies on heart function and blood circulation employing I/sup 131/; applications of C/sup 14/ in studies of leukocyte formation from which it was concluded that peripheral neutrophils have a 2-day life span, large lyphocytes a life span of 2 to 3 days, and small lyphocytes a life span of between 8 and 14 days; tracer studies employing P/sup 32/ in studies of the phagocytic action of cells of the reticuloendothelial system; factors regulating the volume of the body fluids; and development of a method for determining estrogen concentration in urine. Radiation protection activities are summarized. Lists are included of reports issued and papers published during the period. (For preceding period see UCRL-8031.J (C.H.)
[Architectural rendering of Biology Building]
Photograph of the architect's rendering of the biology building for the North Texas State University.
An Evaluation of an Individualized Biology Program
The problem of this study was to compare the achievement and attitude of students in an individualized biology program, modeled after parts of the Proposed Texas Science Framework, with the achievement and attitude of students in conventional biology classes. The subjects used for the study were tenth grade, first year biology students in three high schools in a large North Central Texas city. Each of the three high schools was selected to represent a particular category of high schools. The categories were based upon the mean achievement scores for the students within a school. The categories of schools were above average, medium low, and very low. In each of the schools the classes and teachers in the experimental group and the control group were matched as closely as possible.
Syllabus for Advanced Placement Biology
The purpose of this syllabus is to provide a working copy to those teachers of the advanced placement biology course taught at the high school level. Reference materials used were the Texas Education Agency ( TEA ) approved Campbell text Biology and the College Board's, Advanced Placement Biology Laboratory Manual. The syllabus is divided into major topics with outlined notes and includes laboratory exercises as recommended by the College Board. The AP biology course is intended to be equivalent to college biology. College freshman biology courses can differ among colleges and among teachers within the same college. This syllabus is intended to serve as an aid to AP teachers, to cover the topics and experiments as set out by the College Board, and to the high school student, the necessary material to successfully complete the AP examination while providing freshman biology equivalence.
Electron Paramagnetic Resonance in Biology
A review of the theories of electron paramagnetic resonance in biology is presented, including a discussion of the nature of the physical observation, followed by examples of materials of biological interest. Iq discussing these examples, information is presented in terms of the nature of the starting material under observation rather than the nature of the magnetic entities observed. The examples proceed from the simpler molecules of biological interest (metabolites, vitamins, cofactors) into the more complex materials (polymers, proteins, nucleic acids) toward cellular organelles (mitochondria, chloroplasts) and, finally, to whole cells, organisms and organs. The observation of photoinduced unpaired electrons in photosynthetic material is described and the various parameters controlling it are discussed. The basic observation is interpreted in terms of a primary photophysical act of quantum conversion.
Systems biology approach to bioremediation
Bioremediation has historically been approached as a �black box� in terms of our fundamental understanding. Thus it succeeds and fails, seldom without a complete understanding of why. Systems biology is an integrated research approach to study complex biological systems, by investigating interactions and networks at the molecular, cellular, community, and ecosystem level. The knowledge of these interactions within individual components is fundamental to understanding the dynamics of the ecosystem under investigation. Understanding and modeling functional microbial community structure and stress responses in environments at all levels have tremendous implications for our fundamental understanding of hydrobiogeochemical processes and the potential for making bioremediation breakthroughs and illuminating the �black box�.
[Biology Building Under Construction]
Photograph of the Biology Building under construction on the North Texas campus. The Chemistry Building stands behind the construction site and Bruce Hall is on the left. There is a row of parked cars visible in the bottom left corner.
Semiannual Report for Biology and Medicine
No Description Available.
Biology of the transuranium elements. A bibliography
No Description Available.
[Workers on the Biology Building site]
Photograph of the workers at the construction site of the Biology Building. Some are using a crane in the back along the framing and others on the lower level are spacing the foundation before concrete is poured.
[Biology Building construction 8]
Photograph of the Biology Building being constructed. There are three concrete sections built and finished framing on the first, framing started on the second and workers are visible on the third section. A wall surrounds the construction site and piles of wood planks are out in front of the building.
[Biology Building construction 6]
Photograph of the construction of the new Biology Building. There are three section of concrete with framing built on the first and begun on the second. Workers are visible on the third section. A wall frames the lot and there are piles of wood planks out in front of the building.
[Biology Building construction 2]
Photograph of the Biology Building being constructed. A wall is up around the lot its being built on, cars are lined up in the parking spots in front. Construction workers are visible on the structure.
[Biology Department meeting 5]
Photograph of three Biology Department members gathered around a lab table. Two are seated while the third remains standing. On the table are petri dishes, beakers, droppers, and microscopes.
[Biology researchers begin experiment]
Photograph of two biology researchers, one sitting and one standing, gathered around their station in the lab. The researcher that's sitting is holding a small machine with a point at one end and the one standing is adjusting the overhead light so that everything on the tabletop is visible. Next to the set-up is a tray with various instruments on it, including scissors and tweezers.
[Biology teacher giving presentation]
Photograph of a Biology Department professor writing on an overhead projector during a class lecture. The projection is about the human tissue epithelium. Some students are taking notes while others are looking at the teacher.
[Biology students participating in lab]
Photograph of a biology student looking intently at some form of viewing mechanism. It is a plastic stand that holds a small paper with a pinpoint grid. A plastic arm curves out from where the student is looking. Other students are gathered around while the teacher holds one of the arms.
[Biology Department meeting 1]
Photograph of a meeting of members of the Biology Department. The three men are gathered around a table with microscopes, petri dishes, beakers, and droppers laid out on top.
[Biology Building construction 1]
Photograph of the new Biology Building being constructed on
[Biology Building Exterior 2]
Photograph of one of the exterior corners of the Biology Building after completion. It is three stories and appears to have an attic space. Two entrances can be seen, one on each side visible. Cars are lined up in the spaces outside and people are walking in and out.
[Biology researchers adjusting station]
Photograph of two researchers, one sitting and one standing, at a station set up on a small table. The one sitting is adjusting clamps attached to what appears to be a towel, while the standing researcher adjust the light directly above the set-up. On the table beside the towel is a tray of instruments, including scissors and tweezers.
[Biology Building exterior 4]
Photograph of one of the exterior corners of the Biology Building after completion. It is three stories and appears to have an attic space. Two entrances can be seen, one on each side visible. Cars are lined up in the spaces outside and people are walking in and out.
[Biology Building construction 5]
Photograph of the construction progress of the new biology building. There are three concrete sections with finished framing on the first, framing progress on the second, and workers are visible on the top of the third section. There is a wall around the lot and piles of wood stacked outside.
[Biology Department meeting 2]
Photograph of three Biology Department members in a lab room. They are gathered around a table that has petri dishes, beakers, droppers, and microscopes on it.
[Students walking into Biology Building]
Photograph of university students walking into the Biology Building through its main entrance. The doorway is bordered by two columns and has a lamp above the entrance. Cars are parked along the street in front of it. Beside it the Chemistry Building is visible.
[Biology teacher gives lecture]
Photograph of a biology teacher giving a lecture on "Types of Epithelial Tissue" in a large lecture hall. Some students are taking notes while others are looking up and listening.
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