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Discovering and validating biological hypotheses from coherent patterns in functional genomics data

Description: The area of transcriptomics analysis is among the more established in computational biology, having evolved in both technology and experimental design. Transcriptomics has a strong impetus to develop sophisticated computational methods due to the large amounts of available whole-genome datasets for many species and because of powerful applications in regulatory network reconstruction as well as elucidation and modeling of cellular transcriptional responses. While gene expression microarray data… more
Date: August 12, 2008
Creator: Joachimiak, Marcin Pawel
Item Type: Refine your search to only Presentation
Partner: UNT Libraries Government Documents Department
open access

New developments for the site-specific attachment of protein to surfaces

Description: Protein immobilization on surfaces is of great importance in numerous applications in biology and biophysics. The key for the success of all these applications relies on the immobilization technique employed to attach the protein to the corresponding surface. Protein immobilization can be based on covalent or noncovalent interaction of the molecule with the surface. Noncovalent interactions include hydrophobic interactions, hydrogen bonding, van der Waals forces, electrostatic forces, or physic… more
Date: May 12, 2005
Creator: Camarero, J A
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Final project report

Description: The proposed overarching goal for this project was the following: Data integration, simulation and visualization will facilitate metabolic and regulatory network prediction, exploration, and formulation of hypotheses. We stated three specific aims to achieve the overarching goal of this project: (1) Integration of multiple levels of information such as mRNA and protein levels, predicted protein-protein interactions/associations and gene function will enable construction of models describing env… more
Date: November 12, 2008
Creator: Hood, Nitin S. Baliga and Leroy
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Integrated Omics in Systems Biology: The New Frontier for Environmental Biotechnology

Description: Environmental biotechnology encompasses a wide range of characterization, monitoring and control for bioenergy and bioremediation technologies that are based on biological processes. Recent breakthroughs in our understanding of biogeochemical processes and genomics are leading to exciting new and cost effective ways to monitor and manipulate the environment and potentially produce bioenergy fuels as we also cleanup the environment. Indeed, our ability to sequence an entire microbial genome in j… more
Date: August 12, 2008
Creator: Hazen, Terry C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Berkeley Lab Computing Sciences: Accelerating Scientific Discovery

Description: Scientists today rely on advances in computer science, mathematics, and computational science, as well as large-scale computing and networking facilities, to increase our understanding of ourselves, our planet, and our universe. Berkeley Lab's Computing Sciences organization researches, develops, and deploys new tools and technologies to meet these needs and to advance research in such areas as global climate change, combustion, fusion energy, nanotechnology, biology, and astrophysics.
Date: December 12, 2008
Creator: Hules, John A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

OF MICROBES AND MEN: A SPECIAL REPORT IN THE JOURNAL FOR MINORITY MEDICAL STUDENTS

Description: In support of the mission for the Office of Science and the Office of Biological and Environmental Research (BER), Spectrum Publishers proposes an editorial project to inform and educate minority undergraduate students in the sciences, minority medical students and minority medical residents of the opportunities and challenges available to them as they complete their training. This editorial project will take the form of a 32-page insert in the Journal for Minority Medical Students. The subject… more
Date: November 12, 2008
Creator: BOWERS, BILL
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Biological Sciences for the 21st Century: Meeting the Challenges of Sustainable Development in an Era of Global Change

Description: The symposium was held 10-12 May, 2007 at the Capitol Hilton Hotel in Washington, D. C. The 30 talks explored how some of today's key biological research developments (such as biocomplexity and complex systems analysis, bioinformatics and computational biology, the expansion of molecular and genomics research, and the emergence of other comprehensive or system wide analyses, such as proteomics) contribute to sustainability science. The symposium therefore emphasized the challenges facing agricu… more
Date: May 12, 2007
Creator: Cracraft, Joel & O'Grady, Richard
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

DOE Joint Genome Institute 2008 Progress Report

Description: While initially a virtual institute, the driving force behind the creation of the DOE Joint Genome Institute in Walnut Creek, California in the Fall of 1999 was the Department of Energy's commitment to sequencing the human genome. With the publication in 2004 of a trio of manuscripts describing the finished 'DOE Human Chromosomes', the Institute successfully completed its human genome mission. In the time between the creation of the Department of Energy Joint Genome Institute (DOE JGI) and comp… more
Date: March 12, 2009
Creator: Gilbert, David
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

2008 Co2 Assimilation in Plants: Genome to Biome Gordon Research Conference - August 17-22

Description: Formerly entitled 'CO2 Fixation and Metabolism in Green Plants', this long-standing Gordon Research Conference has been held on a triennial basis since 1976. In 1990 the participants decided to alternate between sites in the U.S. and outside the U.S. The 2005 conference was held in Europe at the Centre Paul Langevin in Aussois, France, so the 2008 conference returns to a U.S. site - the University of New England in Biddeford, Maine. The 2008 conference covers basic plant research related to pho… more
Date: August 12, 2009
Creator: Maroney, James V.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Molecular Basis of Microbial One-Carbon Metabolism 2008 Gordon Research Conference (July 20-25, 2008)

Description: One-carbon (C-1) compounds play a central role in microbial metabolism. C-1 compounds include methane, carbon monoxide, CO2, and methanol as well as coenzyme-bound one-carbon compounds (methyl-B12, CH3-H4folate, etc). Such compounds are of broad global importance because several C-1 compounds (e.g., CH4) are important energy sources, some (e.g., CO2 and CH4) are potent greenhouse gases, and others (e.g., CH2Cl2) are xenobiotics. They are central in pathways of energy metabolism and carbon fixat… more
Date: August 12, 2009
Creator: Ragsdale, Stephen W.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Unraveling the Architecture and Structural Dynamics of Pathogens by High-Resolution in vitro Atomic Force Microscopy

Description: Progress in structural biology very much depends upon the development of new high-resolution techniques and tools. Despite decades of study of viruses, bacteria and bacterial spores and their pressing importance in human medicine and biodefense, many of their structural properties are poorly understood. Thus, characterization and understanding of the architecture of protein surface and internal structures of pathogens is critical to elucidating mechanisms of disease, immune response, physicoche… more
Date: April 12, 2005
Creator: Malkin, A J; Plomp, M; Leighton, T J; McPherson, A & Wheeler, K E
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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