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open access

Isorhamnetin Inhibits Proliferation and Invasion and Induces Apoptosis through the Modulation of Peroxisome Proliferator-activated Receptor ϒ Activation Pathway in Gastric Center

Description: Article on PPAR-γ, a nuclear transcription factor that plays a critical role in the development of gastric cancer.
Date: November 2, 2012
Creator: Ramachandran, Lalitha; Manu, Kanjoormana Aryan; Shanmugam, Muthu K.; Li, Feng; Siveen, Kodappully Sivaraman; Vali, Shireen et al.
open access

Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma

Description: Article on the potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma.
Date: October 26, 2012
Creator: Subramaniam, Aruljothi; Shanmugam, Muthu K.; Perumal, Ekambaram; Li, Feng; Nachiyappan, Alamelu; Dai, Xiaoyun et al.
open access

Effect of selection for commercially productive traits on the plasticity of cardiovascular regulation in chicken breeds during embryonic development

Description: Article investigates basic cardiovascular physiology in the Red Junglefowl, the broiler, and the White Leghorn breeds at 90% of incubation. The authors aimed to identify breed-specific features of arterial blood pressure and heart rate as well as the physiological mechanisms regulating them. They concluded that selection for rapid growth shifts cardiovascular regulatory plasticity to emphasize mechanisms that modulate pressure, and that selection for egg-laying capacity emphasizes mechanisms th… more
Date: October 1, 2012
Creator: Crossley, Dane A., II & Altimiras, J.
open access

Changes in Cell Wall Carbohydrate Extractability are Correlated with Reduced Recalcitrance of HCT Downregulated Alfalfa Biomass

Description: Article on changes in cell wall carbohydrate extractability and how these are correlated with reduced recalcitrance of hydroxycinnamoyl transferase (HCT) downregulated alfalfa biomass.
Date: August 2012
Creator: Pattathil, Sivakumar; Saffold, Trina; Gallego-Giraldo, Lina; O'Neill, Malcolm; York, William S.; Dixon, R. A. et al.
open access

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

Description: Article on the targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids and the potential role in prevention and therapy of cancer.
Date: July 28, 2012
Creator: Shanmugam, Muthu K.; Nguyen, An H.; Kumar, Alan Prem; Tan, Benny K-H & Sethi, Gautam
open access

An UPLC-ESI-MS/MS Assay Using 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate Derivatization for Targeted Aminio Acid Analysis: Application to Screening of Arabidopsis thaliana Mutants

Description: This article presents a method that enables thirty-eight metabolites (proteinogenic amino acids and related compounds) to be analyzed, with an improved sensitivity of 1 to 5 orders of magnitude compared to existing methods.
Date: July 6, 2012
Creator: Salazar, Carolina; Armenta, Jenny M. & Shulaev, Vladimir
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