This review article summarizes the involvement and interaction between long-distance systemic acquired resistance (SAR) signals and details the recently discovered role of lysine catabolite pipecolic acid (Pip) in defense amplification and priming that allows plants to acquire immunity at the systemic level.
Article on the targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids and the potential role in prevention and therapy of cancer.
Article on ursolic acid inhibiting the initiation, progression of prostate cancer and prolonging the survival of TRAMP mice by modulating pro-inflammatory pathways.
Article on the identification of cDNA clones encoding valosin-containing protein and other plant plasma membrane-associated proteins by a general immunoscreening strategy.
This article reports the draft F. vesca genome, which was sequenced to x39 coverage using second-generation technology, assembled de novo and then anchored to the genetic linkage map into seven pseudochromosomes.
Article reviews the common dysregulation of phosphatidylinositol-3 kinases (PI3K)/Akt/mTOR pathway in gastric cancer (GC) and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment.
This article investigates the metabolism, growth and muscle mitochondrial function in hatchlings of a turtle and a crocodilian, two ectotherms that never develop endothermy.
Article describing an investigation into whether γ-tocotrienol can abrogate angiogenesis-mediated tumor growth in hepatocellular carcinoma (HCC) and if so, through what molecular mechanisms.
Article investigates whether thymoquinone (TQ), a bioactive constituent of black seed oil, could suppress the proliferation and induce chemosensitization in human myeloma cells and xenograft mouse model. Overall, the results demonstrate that TQ can enhance the anticancer activity of bortezomib in vitro and in vivo and may have a substantial potential in the treatment of MM.
In this article, the authors evaluate the effect of lupeol on STAT3 signalling cascade and its regulated functional responses in hepatocellular carcinoma (HCC) cells. Constitutive activation of signal transducer and activator of transcription signalling 3 (STAT3) has been linked with survival, proliferation and angiogenesis in a wide variety of malignancies including HCC. Lupeol exhibited its potential anticancer effects in HCC through the downregulation of STAT3-induced pro-survival signalling cascade.
This article observes genetic and biochemical support for the importance of folylpolyglutamates in the lignocellulosic pathway and reinforces previous observations that targeting a single FPGS isoform for down-regulation leads to reduced lignin in plants.
This article discusses the effect and overall importance of the Arabidopsis thaliana AtSUC2 sucrose-proton symporter gene on carbon partitioning and plant growth.
This article presents herpetofaunal observations from Limnos and Agios Efstratios, two Asia Minor continental shelf islands in the Aegean Sea. Comprehensive surveys over 88 days in total on Limnos, over a period of nine years, consisted mainly of visual encounter surveys and road cruised observations, revealed the presence of three species of amphibians and twelve species of reptiles, including two new species records for the island (Malpolon insignitus and Pelobates syriacus). The results of these surveys provide a clearer understanding of the extant herpetofauna on Limnos and Agios Efstratios and offer discussion on natural history, possible erroneous historical records and preliminary ecological understanding of the herpetofaunal assemblages residing on these islands.
Article on an anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins.
Article on the potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma.
Article on methyl jasmonate and yeast elicitor induce differential transcriptional and metabolic re-programming in cell suspension cultures of the model legume Medicago truncatula.
This article contains RNA sequencing analysis of Arabidopsis thaliana plants subjected to light stress in order to identify and characterize rapid changes in the steady-state level of different transcripts in response to light stress.
Article discussing enhanced seed production under prolonged heat stress conditions in Arabidopsis thaliana plants deficient in cytosolic ascorbate peroxidase 2.
Article accompanying a poster for the 2010 Computational Neuroscience Annual Meeting. This article discusses computational criteria for establishing reflex from plasticity to hardwiring.
Article accompanying a poster presentation for the 2014 Annual Computational Neuroscience Meeting. This article discusses computational optimization problems in social interaction and empathic social emotion.
Article accompanying a poster presentation for the 2011 Computational Neuroscience Annual Meeting. This article discusses research on contributing factors in the judgement of fairness by monetary value.
Article accompanying a poster presentation for the 2012 Computational Neuroscience Annual Meeting. This article discusses the derivation of the evolution of empathic other-regarding social emotions as compared to non-social self-regarding emotions.
In this article, a theoretical model of social empathic emotion is derived based on the principles of survival by extending the maximization of self-gains to include others as an extended-self. This extended-self model of optimization for survival provides the computational mechanisms in the optimization process to maximize self-gains without minimizing the gains (or maximizing losses) for the other individuals. Thus, it can resolve conflicts in a competitive environment, and change the social dynamics into a cooperative interaction instead.
Article accompanying a poster presentation for the 2011 Computational Neuroscience Annual Meeting. This article discusses gender difference of emotional bias in sharing love.
Article accompanying a poster presentation for the 2014 Annual Computational Neuroscience Meeting. This article discusses optical imaging of prefrontal cortex hemodynamic response in executive function induced by increased cardiovascular activity.
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