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Long-distance communication and signal amplication in systemic acquired resistance

Description: This review article summarizes the involvement and interaction between long-distance systemic acquired resistance (SAR) signals and details the recently discovered role of lysine catabolite pipecolic acid (Pip) in defense amplification and priming that allows plants to acquire immunity at the systemic level.
Date: February 22, 2013
Creator: Shah, Jyoti & Zeier, Jürgen
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Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

Description: Article on the targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids and the potential role in prevention and therapy of cancer.
Date: July 28, 2012
Creator: Shanmugam, Muthu K.; Nguyen, An H.; Kumar, Alan Prem; Tan, Benny K-H & Sethi, Gautam
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Ursolic Acid Inhibits the Initiation, Progression of Prostate Cancer and Prolongs the Survival of TRAMP Mice by Modulating Pro-Inflammatory Pathways

Description: Article on ursolic acid inhibiting the initiation, progression of prostate cancer and prolonging the survival of TRAMP mice by modulating pro-inflammatory pathways.
Date: March 12, 2012
Creator: Shanmugam, Muthu K.; Ong, Tina H.; Kumar, Alan Prem; Chang, Kai Lun; Ho, Paul C.; Wong, Peter T. H. et al.
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Identification of cDNA clones encoding valosin-containing protein and other plant plasma membrane-associated proteins by a general immunoscreening strategy

Description: Article on the identification of cDNA clones encoding valosin-containing protein and other plant plasma membrane-associated proteins by a general immunoscreening strategy.
Date: May 1, 1995
Creator: Shi, Jinrui; Dixon, R. A.; Gonzales, Robert A.; Kjellbom, Per & Bhattacharyya, Madan Kumar
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The Genome of Woodland Strawberry (Fragaria Vesca)

Description: This article reports the draft F. vesca genome, which was sequenced to x39 coverage using second-generation technology, assembled de novo and then anchored to the genetic linkage map into seven pseudochromosomes.
Date: December 26, 2010
Creator: Shulaev, Vladimir; Sargent, Daniel J.; Crowhurst, Ross N.; Mockler, Todd C.; Folkerts, Otto; Delcher, Arthur et al.
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Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?

Description: Article reviews the common dysregulation of phosphatidylinositol-3 kinases (PI3K)/Akt/mTOR pathway in gastric cancer (GC) and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment.
Date: October 26, 2015
Creator: Singh, Shikha Satendra; Yap, Wei Ney; Arfuso, Frank; Kar, Shreya; Wang, Chao; Cai, Wanpei et al.
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Post-hatching development of mitochondrial function, organ mass and metabolic rate in two ectotherms, the American alligator (Alligator mississippiensis) and the common snapping turtle (Chelydra serpentina)

Description: This article investigates the metabolism, growth and muscle mitochondrial function in hatchlings of a turtle and a crocodilian, two ectotherms that never develop endothermy.
Date: March 9, 2016
Creator: Sirsat, Sarah K. G.; Sirsat, Tushar S.; Price, Edwin R. & Dzialowski, Edward M. (Edward Michael)
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γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mammalian target of rapamycin pathway in an orthotopic mouse model

Description: Article describing an investigation into whether γ-tocotrienol can abrogate angiogenesis-mediated tumor growth in hepatocellular carcinoma (HCC) and if so, through what molecular mechanisms.
Date: March 31, 2014
Creator: Siveen, Kodappully Sivaraman; Ahn, Kwang Seok; Ong, Tina H.; Shanmugam, Muthu K.; Li, Feng; Yap, Wei Ney et al.
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Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model

Description: Article investigates whether thymoquinone (TQ), a bioactive constituent of black seed oil, could suppress the proliferation and induce chemosensitization in human myeloma cells and xenograft mouse model. Overall, the results demonstrate that TQ can enhance the anticancer activity of bortezomib in vitro and in vivo and may have a substantial potential in the treatment of MM.
Date: December 18, 2013
Creator: Siveen, Kodappully Sivaraman; Mustafa, Nurulhuda; Li, Feng; Kannaiyan, Radhamani; Ahn, Kwang Seok; Kumar, Alan Prem et al.
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Negative Regulation of Signal Transducer and Activator of Transcription-3 Signalling Cascade by Lupeol Inhibits Growth and Induces Apoptosis in Hepatocellular Carcinoma Cells

Description: In this article, the authors evaluate the effect of lupeol on STAT3 signalling cascade and its regulated functional responses in hepatocellular carcinoma (HCC) cells. Constitutive activation of signal transducer and activator of transcription signalling 3 (STAT3) has been linked with survival, proliferation and angiogenesis in a wide variety of malignancies including HCC. Lupeol exhibited its potential anticancer effects in HCC through the downregulation of STAT3-induced pro-survival signalling… more
Date: August 7, 2014
Creator: Siveen, Kodappully Sivaraman; Nguyen, An H.; Lee, J. H.; Li, Feng; Singh, S. S.; Kumar, Alan Prem et al.
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