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open access

Metabolic engineering of raffinose-family oligosaccharides in the phloem reveals alterations in carbon partitioning and enhances resistance to green peach aphid

Description: This article discusses the use of metabolic engineering to generate raffinose-family oligosaccharides (RFOs) at the inception of the translocation stream of Arabidopsis thaliana, which loads from the apoplasm and transports predominantly sucrose, and the fate of the sugars through the plant determined.
Date: July 19, 2013
Creator: Cao, Te; Lahiri, Ipsita; Singh, Vijay; Louis, Joe; Shah, Jyoti & Ayre, Brian G.
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open access

Long-distance communication and signal amplication in systemic acquired resistance

Description: This review article summarizes the involvement and interaction between long-distance systemic acquired resistance (SAR) signals and details the recently discovered role of lysine catabolite pipecolic acid (Pip) in defense amplification and priming that allows plants to acquire immunity at the systemic level.
Date: February 22, 2013
Creator: Shah, Jyoti & Zeier, Jürgen
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Comparative Genomics of Cluster O Mycobacteriophages

Description: This article describes a group of five closely related mycobacteriophages--Corndog, Catdawg, Dylan, Firecracker, and YungJamal--designated as Cluster O with long flexible tails but with unusual prolate capsids
Date: March 5, 2015
Creator: Cresawn, Steven G.; Pope, Welkin H.; Jacobs-Sera, Deborah; Bowman, Charles A.; Russell, Daniel A.; Dedrick, Rebekah M. et al.
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open access

ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and c-Myc to reduce breast cancer proliferation

Description: This article shows that miR196a was highly expressed in ER+MCF-7 breast cancer cells when compared to normal mammary gland cells, with expression levels negatively correlating to ANXA1.
Date: April 20, 2016
Creator: Yuan, Yi; Anbalagan, Durkeshwari; Lee, Lay Hoon; Samy, Ramar Perumal; Shanmugam, Muthu K.; Kumar, Alan Prem et al.
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open access

Gelsolin-Cu/Znsod Interaction Alters Intracellular Reactive Oxygen Species Levels to Promote Cancer Cell Invasion

Description: This article shows that increased gelsolin enhances the invasive capacity of colon cancer cells, and this is mediated via gelsolin's effects in elevating intracellular superoxide levels.
Date: July 6, 2016
Creator: Tochhawng, Lalchhandami; Deng, Shuo; Pugalenthi, Ganesan; Kumar, Alan Prem; Lim, Kiat Hon; Yang, Henry et al.
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open access

The Prognostic Value of the Stem-Like Group in Colorectal Cancer Using a Panel of Immunohistochemistry Markers

Description: This article examines the immunohistochemical expression profile of 18 markers, each representing a putative role in cancer development, in 493 primary colorectal carcinomas using tissue microarrays.
Date: March 26, 2015
Creator: Ong, Chee Wee; Chong, Pei Yi; McArt, Darragh G.; Chan, Jason Yongsheng; Tan, Hwee Tong; Kumar, Alan Prem et al.
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open access

Novel aromatase inhibitors selection using induced fit docking and extra precision methods: Potential clinical use in ER-alpha-positive breast cancer

Description: This article aims to identify new molecules which could block or suppress the activity of aromatase enzyme by molecular docking studies using Schrödinger-Maestro v9.3.
Date: October 10, 2016
Creator: Kumavath, Ranjith; Azad, Manan; Devarapalli, Pratap; Tiwari, Sandeep; Kar, Shreya; Barh, Debmalya et al.
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open access

Erratum to: More Comprehensive Forensic Genetic Marker Analyses for Accurate Human Remains Identification Using Massively Parallel DNA Sequencing

Description: This article provides erratum for the article "More Comprehensive Forensic Genetic Marker Analyses for Accurate Human Remains Identification Using Massively Parallel DNA Sequencing," which incorrectly deleted an author from the author list.
Date: April 20, 2017
Creator: Ambers, Angie D.; Churchill, Jennifer D.; King, Jonathan L.; Stoljarova, Monika; Gill-King, Harrell; Assidi, Mourad et al.
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open access

The Genome of Woodland Strawberry (Fragaria Vesca)

Description: This article reports the draft F. vesca genome, which was sequenced to x39 coverage using second-generation technology, assembled de novo and then anchored to the genetic linkage map into seven pseudochromosomes.
Date: December 26, 2010
Creator: Shulaev, Vladimir; Sargent, Daniel J.; Crowhurst, Ross N.; Mockler, Todd C.; Folkerts, Otto; Delcher, Arthur et al.
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open access

Developmental plasticity of mitochondrial function in American alligators, Alligator mississippiensis

Description: This article investigates the effects of chronic developmental hypoxia on cardiac mitochondrial function in embryonic and juvenile American alligators (Alligator mississippiensis).
Date: October 1, 2016
Creator: Galli, Gina L. J.; Crossley, Janna; Elsey, Ruth M.; Dzialowski, Edward M. (Edward Michael); Shiels, Holly A. & Crossley, Dane A., II
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open access

Evolutionary implications of the distribution and variation of the skeletal muscles of the anuran lymphatic system

Description: This article defines character states and describes variation of these putative lymphatic skeletal muscles: the M. cutaneus pectoris, M. cutaneus dorsi, M. piriformis, M. sphincter ani cloacalis, and the complex of the M. gracilis minor/M. abdominal crenator.
Date: April 3, 2013
Creator: Drewes, Robert C.; Hillman, Stanley S.; Hedrick, Michael & Withers, Philip C.
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open access

Interactions between mitoNEET and NAF-1 in cells

Description: This article uses yeast two-hybrid to demonstrate through vivo bimolecular fluorescence complementation (BiFC), direct coupling analysis (DCA), RNA-sequencing, ROS and iron imaging, and single and double shRNA lines with suppressed mNT, NAF-1 and mNT/NAF-1 expression, that mNT and NAF-1 directly interact in mammalian cells and could function in the same cellular pathway.
Date: April 20, 2017
Creator: Karmi, Ola; Holt, Sarah H.; Song, Luhua; Tamir, Sagi; Luo, Yuting; Bai, Fang et al.
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open access

Malonylation of Glucosylated N-Lauroylethanolamine: A New Pathway That Determines N-Acylethanolamine Metabolic Fate in Plants

Description: This article focuses on the gene At5g39050, which encodes a phenolic glucoside malonyltransferase 1 (PMAT1), to better understand the biological significance of N-lauroylethanolamine (NAE 12:0)-induced gene expression changes.
Date: November 17, 2016
Creator: Khan, Bibi Rafeiza; Wherritt, Daniel J.; Huhman, David; Sumner, Lloyd W.; Chapman, Kent D. & Blancaflor, Elison B.
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open access

Synthesis of Phenoxyacyl-Ethanolamides and Their Effects on Fatty Acid Amide Hydrolase Activity

Description: This article discusses the synthesis of two sets of phenoxyacyl-ethanolamides from natural products, 3-n-pentadecylphenolethanolamide and cardanolethanolamide, with structural similarity to N-Acylethanolamines and characterizes their effects on the hydroltic activity of fatty acid amide hydrolase.
Date: February 20, 2014
Creator: Faure, Lionel; Nagarajan, Subbiah; Hwang, Hyeondo; Montgomery, Christa L.; Khan, Bibi Rafeiza; John, George et al.
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open access

Wnt signaling in triple-negative breast cancer

Description: This review summarizes the involvement of dysregulated Wnt signaling in the progression of triple-negative breast cancer (TNBC) and TNBC stem cells, as well as the emerging therapies that are currently under investigation.
Date: January 24, 2017
Creator: Pohl, Sebastian Öther-Gee; Brook, N; Agostino, M.; Arfuso, Frank & Kumar, Alan Prem
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open access

Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4

Description: This article describes findings that demonstrate the affect of diosgenin (DG) on inhibiting the resilient breast cancer stem cells (CSCs) which could provide a benchmark for the development of DG-based therapies in breast cancer treatment.
Date: March 20, 2017
Creator: Bhuvanalakshmi, G.; Basappa; Rangappa, Kanchugarakoppal S.; Dharmarajan, Arunasalam; Sethi, Gautam; Kumar, Alan Prem et al.
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open access

Novel transcriptome assembly and comparative toxicity pathway analysis in mahi-mahi (Coryphaena hippurus) embryos and larvae exposed to Deepwater Horizon oil

Description: This article establishes the de novo transcriptomic database from the embryos and larvae of mahi-mahi exposed to water accommodated fractions (HEWAFs) of two Deepwater Horizon oil types (weathered and source oil) in an effort to advance understanding of the molecular aspects involved during specific toxicity responses.
Date: March 15, 2017
Creator: Xu, Elvis Genbo; Mager, Edward M.; Grosell, Martin; Hazard, E. Starr; Hardiman, Gary & Schlenk, Daniel
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open access

Dry Season Limnological Conditions and Basin Geology Exhibit Complex Relationships With δ¹³C and δ¹⁵N of Carbon Sources in Four Neotropical Floodplains

Description: This article assesses the potential for basin geology and local limnological conditions to predict stable carbon and nitrogen isotope values of six carbon sources at multiple locations in four Neotropical floodplain ecosystems (Paranaá , Pantanal, Araguaia, and Amazon).
Date: March 30, 2017
Creator: Alves, Gustavo H. Zaia; Hoeinghaus, David; Manetta, Gislaine I. & Benedito, Evanilde
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open access

A Comparison of Least Squares Regression and Geographically Weighted Regression Modeling of West Nile Virus Risk Based on Environmental Parameters

Description: This article discusses the effectiveness of utilizing local spatial variations in environmental data to uncover the statistical relationships between West Nile Virus (WNV) risk and environmental factors.
Date: March 28, 2017
Creator: Kala, Abhishek K.; Tiwari, Chetan; Mikler, Armin R. & Atkinson, Samuel F.
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open access

We Need Better Understanding About Functional Diversity and Vulnerability of Tropical Freshwater Fishes

Description: This commentary extends a discussion initiated by Toussaint et al. (Sci Rep 6:22125, 2016) concerning the relationship between global patterns of freshwater fish functional diversity (FD) and its vulnerability to human impacts.
Date: November 19, 2016
Creator: Vitule, Jean R. S.; Agostinho, Angela A.; Azevedo-Santos, Valter M.; Daga, Vanessa S.; Darwall, William R. T.; Fitzgerald, Daniel B. et al.
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open access

Lophozonia tree cavities used for nesting by Slender-billed Parakeets (Enicognathus leptorhynchus) in the central valley of southern Chile: a potentially vanishing keystone resource

Description: This article describes and quantifies characteristics of southern beech (Lophoonia obliqua) trees and their associated cavities used for nesting by Slender-billed Parakeets in the central valley of southern Chile.
Date: February 6, 2017
Creator: White, Thomas H., Jr. & Jiménez, Jaime E.
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