Somatostatin Receptors on Neuronal Cilia: Evidence for Neuroprotection
Description:
Primary cilia are essential in brain development, as mediators of sonic hedgehog signaling. However, their role in mature neurons remains elusive. One means to elucidate their function may be to investigate the function of the somatostatin type 3 receptor (SstR3), which is concentrated on the primary cilia of neurons. The inhibitory and anticonvulsant properties of somatostatin suggest that ciliary SstR3 might protect neurons against excitotoxicity, as seen in epileptic seizures. C57BL/6 wi…
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Date:
December 2012
Creator:
Evans, Shakila K.