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  Partner: UNT Libraries
 Degree Discipline: Chemistry
 Collection: UNT Theses and Dissertations
a-Amino Alcohol Derivatives of Methyl P-Nitrophenyl Acetate

a-Amino Alcohol Derivatives of Methyl P-Nitrophenyl Acetate

Date: 1947
Creator: Prindle, Hershel B.
Description: This thesis describes the synthesis of a series of dialkylaminoalkoxy derivatives of methyl p-nitrophenylacetate for testing as anti-histamine or hay fever drugs.
Contributing Partner: UNT Libraries
An analysis of the effectiveness of computer assisted instruction in general chemistry at an urban university.

An analysis of the effectiveness of computer assisted instruction in general chemistry at an urban university.

Date: May 2002
Creator: McGuffey, Angela
Description: The science-major General Chemistry sequence offered at the University of Houston has been investigated with respect to the effectiveness of recent incorporation of various levels of computer technology. As part of this investigation, questionnaire responses, student evaluations and grade averages and distributions from up to the last ten years have been analyzed and compared. Increased use of web-based material is both popular and effective, particularly with respect to providing extra information and supplemental questions. Instructor contact via e-mail is also well-received. Both uses of technology should be encouraged. In contrast, electronic classroom presentation is less popular. While initial use may lead to improved grades and retention, these levels decrease quickly, possibly due to a reduction in instructor spontaneity.
Contributing Partner: UNT Libraries
An Application of the Reformatsky Reaction to the Thiophene Series of Compounds

An Application of the Reformatsky Reaction to the Thiophene Series of Compounds

Date: 1949
Creator: Hicks, Howard A.
Description: In view of the increasing importance of thiophene derivatives as chemotherapeutic agents, it was considered of interest to apply the Reformatsky reaction to the synthesis of compounds containing the thiophene nucleus with the thought that these might serve as intermediates for further syntheses.
Contributing Partner: UNT Libraries
Applications of nanomanipulation coupled to nanospray mass spectrometry in trace fiber analysis and cellular lipid analysis.

Applications of nanomanipulation coupled to nanospray mass spectrometry in trace fiber analysis and cellular lipid analysis.

Date: December 2008
Creator: Ledbetter, Nicole
Description: The novel instrumentation of nanomanipulation coupled to nanospray mass spectrometry and its applications are presented. The nanomanipulator has the resolution of 10nm step sizes allowing for specific fine movement used to probe and characterize objects of interest. Nanospray mass spectrometry only needs a minimum sample volume of 300nl and a minimum sample size of 300attograms to analyze an analyte making it the ideal instrument to couple to nanomanipulation. The nanomanipulator is mounted to an inverted microscope and consists of 4 nano-positioners; these nano-positioners hold end-effectors and other tools used for manipulation. This original coupling has been used to enhance the current abilities of cellular probing and trace fiber analysis. Experiments have been performed to demonstrate the functionality of this instrument and its capabilities. Histidine and caffeine have been sampled directly from single fibers and analyzed. Lipid bodies from cotton seeds have been sampled indirectly and analyzed. The few applications demonstrated are only the beginning of nanomanipulation coupled to nanospray mass spectrometry and the possible applications are numerous especially with the ability to design and fabricate new end-effectors with unique abilities. Future study will be done to further the applications in direct cellular probing including toxicology studies and organelle analysis of ...
Contributing Partner: UNT Libraries
An Approach Towards the Total Synthesis of Clonostachydiol

An Approach Towards the Total Synthesis of Clonostachydiol

Date: August 1995
Creator: Maiti, Tushar B. (Tushar Baran)
Description: The syntheses of the unsymmetrical 14-membered bismacrolides have been reviewed. A total synthesis of clonostachydiol, the latest to join this family, has been attempted using trimethylsilyl acetylene as the builiding block and palladium catalyzed reactions for the formation of key bonds. The alkyne groups were introduced by Stille coupling of trimethylstannylethynyltrimethylsilane with an acid chloride for one fragment and by addition of lithiotrimethylsilyl acetylene to an aldehyde for the other. Lactic acid derivatives were chosen as starting materials for both fragments, thus introducing two of the chiral centers. The remaining stereocenters were introduced using stereoselective reductions of ketones.
Contributing Partner: UNT Libraries
Aromatic Amino Acid Studies

Aromatic Amino Acid Studies

Date: December 1970
Creator: Sullivan, Patrick Timothy
Description: Pyridine ring analogs of the aromatic amino acids phenylalanine and tyrosine were synthesized and studied in microbiological and mammalian systems.
Contributing Partner: UNT Libraries
The Ascorbic Acid Metabolism of Fifty College Women in the North Texas State Teachers College

The Ascorbic Acid Metabolism of Fifty College Women in the North Texas State Teachers College

Date: 1943
Creator: Harshbarger, Marjorie
Description: A study of the ascorbic acid metabolism of a group of fifty college women in the North Texas State Teachers College between the months of April and July, 1943.
Contributing Partner: UNT Libraries
Attempted Synthesis of 5,5-di(2-thienyl)barbituric acid

Attempted Synthesis of 5,5-di(2-thienyl)barbituric acid

Date: 1944
Creator: Pickard, Porter Louis
Description: This study is an attempted synthesis of dithienyl barbituric acid.
Contributing Partner: UNT Libraries
Attempted Synthesis of 5-Allyl-5-(2-Thienyl)-Barbituric Acid

Attempted Synthesis of 5-Allyl-5-(2-Thienyl)-Barbituric Acid

Date: 1947
Creator: Skinner, Charles Gordon
Description: This thesis describes attempts to synthesize 5-allyl-5-(2-thienyl)-barbituric acid as an improved anticonvulsant.
Contributing Partner: UNT Libraries
Baeyer-Villiger Oxidation of 1,7- & 1,9-dibromopentacyclo[5.4.0.02,6.03,10.05,9]undecane-8,11-dione

Baeyer-Villiger Oxidation of 1,7- & 1,9-dibromopentacyclo[5.4.0.02,6.03,10.05,9]undecane-8,11-dione

Access: Use of this item is restricted to the UNT Community.
Date: May 2004
Creator: Akinola, Adeniyi O.
Description: Baeyer-Villiger oxidation of 1,9-dibromopentacyclo[5.4.0.02,6.03,10.05,9]undecane-8,11-dione (1,9-dibromo-PCU-8,11-dione) was performed by using an excess amount of m-chloroperbenzoic acid (3 equivalents) and resulted in the formation of the corresponding monolactone. The reaction would not proceed to the dilactone stage. The structure of the reaction product was established unequivocally via single crystal X-ray diffraction. Baeyer-Villiger oxidation of 1,9-dibromo-PCU-8,11-dione using ceric ammonium nitrate (CAN) was also performed and afforded a mixture of lactones. Only one of these lactones, which also contained an alkene functionality, could be isolated and characterized. 1,7-dibromo-PCU-8,11-dione was also reacted with CAN, yielding the mono-lactone, which has also been characterized.
Contributing Partner: UNT Libraries