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Age-Dependent Effects Of Chronic GABAA Receptor Blockade In Barrel Cortex

Description: GABAA receptor binding is transiently increased in rat whisker barrels during the second postnatal week, at a time when neurons in the developing rat cortex are vulnerable to excitotoxic effects. To test whether these GABAA receptors might serve to protect neurons from excessive excitatory input, polymer implants containing the GABAA receptor antagonist bicuculline were placed over barrel cortex for a 4-day period in young (postnatal days 8 - 12) and adult rats. In the cortex of young, but no… more
Date: May 2001
Creator: Gargan, Lynn
Item Type: Refine your search to only Thesis or Dissertation
open access

Unique applications of cultured neuronal networks in pharmacology, toxicology, and basic neuroscience

Description: This dissertation research explored the capabilities of neuronal networks grown on substrate integrated microelectrode arrays in vitro with emphasis on utilizing such preparations in three specific application domains: pharmacology and drug development, biosensors and neurotoxicology, and the study of burst and synaptic mechanisms. Chapter 1 details the testing of seven novel AChE inhibitors, demonstrating that neuronal networks rapidly detect small molecular differences in closely related comp… more
Date: May 2001
Creator: Keefer, Edward W.
Item Type: Refine your search to only Thesis or Dissertation
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