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open access

Measuring Biomarkers From Dried Blood Spots Utilizing Bead-based Multiplex Technology

Description: Dried blood spots is an alternative method to collect blood samples from research subjects. However, little is known about how hemoglobin and hematocrit affect bead-based multiplex assay performance. The purpose of this study was to determine how bead-based multiplex assays perform when analyzing dried blood spot samples. A series of four experiments outline the study each with a specific purpose. A total of 167 subject samples were collected and 92 different biomarkers were measured. Median fl… more
Date: December 2014
Creator: Prado, Eric A.
Item Type: Refine your search to only Thesis or Dissertation
open access

Metabolic Engineering in Plants to Control Source/sink Relationship and Biomass Distribution

Description: Traditional methods like pruning and breeding have historically been used in crop production to divert photoassimilates to harvested organs, but molecular biotechnology is now poised to significantly increase yield by manipulating resource partitioning. It was hypothesized that metabolic engineering in targeted sink tissues can favor resource partitioning to increase harvest. Raffinose Family Oligosaccharides (RFOs) are naturally occurring oligosaccharides that are widespread in plants and are … more
Date: August 2013
Creator: Lahiri, Ipsita
Item Type: Refine your search to only Thesis or Dissertation
open access

Metabolic Engineering of Raffinose-Family Oligosaccharides in the Phloem Reveals Alterations in Patterns of Carbon Partitioning and Enhances Resistance to Green Peach Aphid

Description: Phloem transport is along hydrostatic pressure gradients generated by differences in solute concentration between source and sink tissues. Numerous species accumulate raffinose-family oligosaccharides (RFOs) in the phloem of mature leaves to accentuate the pressure gradient between source and sinks. In this study, metabolic engineering was used to generate RFOs at the inception of the translocation stream of Arabidopsis thaliana, which transports predominantly sucrose. To do this, three genes, … more
Date: August 2010
Creator: Cao, Te
Item Type: Refine your search to only Thesis or Dissertation
open access

Modeling the Relationship Between Golden Algae Blooms in Lake Texoma, Usa, Versus Nearby Land Use and Other Physical Variables

Description: Pyrmnesium parvum, commonly known as golden algae, is an algal species that under certain circumstances releases toxins which can lead to fish kills and the death of other economically and ecologically important organisms. One of the major objectives of the study was to investigate whether a relationship exists between land use and Prymnesium parvum abundance in littoral sites of Lake Texoma, USA. Another objective was to investigate whether a relationship exists between other physical variable… more
Date: August 2012
Creator: Ware, Trudy M.
Item Type: Refine your search to only Thesis or Dissertation
open access

Modulation of the Coelomic Fluid Protein Profile in the Earthworm, Lumbricus Terrestris, After Exposure to Copper as Copper Sulfate

Description: Proteomic techniques were used to analyze the protein profile of earthworm, Lumbricus terrestris, coelomic fluid collected by either whole body dissection method or the coelomic cavity puncture method. Data demonstrated that collection of coelomic fluid using the coelomic cavity puncture method protocol resulted in a 32% reduction, 377 +/- 4.5 vs 253+/- 19.9 (p=0.0007), in the number of individual proteins. It was determined that the coelomic cavity puncture method yielded a "cleaner" preparati… more
Date: May 2010
Creator: Herring, Reese
Item Type: Refine your search to only Thesis or Dissertation
open access

Molecular systematics of Baird's pocket gopher (Geomys breviceps)

Description: Baird's pocket gopher (Geomys breviceps) is found in eastern Texas, eastern Oklahoma, central and western Arkansas, and western Louisiana. The cytochrome-b gene was sequenced and analyzed for 16 pocket gophers from throughout the range of the species. Similar phylogenetic trees were obtained using maximum-parsimony, maximum-likelihood, neighbor-joining, and Bayesian analyses. Two major clades were formed with northern individuals belonging to clade I and southern individuals belonging to clade … more
Date: August 2010
Creator: Bodine, Deanna Martinez
Item Type: Refine your search to only Thesis or Dissertation
open access

Monitoring Monocyte Oxldl Phagocytosis As a Cardiovascular Disease Risk Factor Following a High-fat Meal

Description: Macrophage-derived foam cells play a predominant role in the deposition of arterial plaques during the early stages of atherosclerosis. The deposition of arterial plaques is known to be effected by several factors, including a person’s dietary habits. The consumption of a high-fat (>60% of calories from fat) meal is known to elevate serum LDL and triglycerides, which have been previously implicated in the formation pf foam cells. One limitation of current research models is that it is not possi… more
Date: December 2014
Creator: Henning, Andrea L.
Item Type: Refine your search to only Thesis or Dissertation
open access

Museum education: Creation, implementation, and evaluation of a web-based Elm Fork Natural Heritage Museum

Description: Evaluation of museum audiences both in their physical and web-based spaces is a necessary component of museum education. For smaller museums without the personnel or knowledge to create a website and evaluate the on-line audience, using a web-based learning tool may be able to help these museums properly maintain an online site. A web-based Elm Fork Natural Heritage Museum (WBEFNHM) was created during the 2008 fall semester at the University of North Texas. The site included photographs and … more
Date: December 2010
Creator: Lundeen, Melissa
Item Type: Refine your search to only Thesis or Dissertation
open access

Neurological Responses to a Glucose Diet in Caenorhabditis elegans

Description: TRPV channels play a role in both mammalian insulin signaling, with TRPV1 expression in pancreatic beta-cells, and in C. elegans insulin-like signaling through expression of OSM-9, OCR-1, and OCR-2 in stress response pathways. In response to a glucose-supplemented diet, C. elegans are know to have sensitivity to anoxic stress, exhibit chemotaxis attraction, and display reduced egg-laying rate. Transcriptome analysis reveals that glucose stimulates nervous system activity with increased transcri… more
Date: August 2017
Creator: Dumesnil, Dennis
Item Type: Refine your search to only Thesis or Dissertation
open access

Neurotoxicity of the Industrial Solvent 4-Methylcyclohexanemethanol: Involvement of the GABA Receptor

Description: A recent chemical spill of 4-Methylcyclohexanemethanol (4-MCHM) in West Virginia left 300,000 people without water. Officials claimed that this compound is not lethally toxic, but potentially harmful if swallowed or inhaled, and can cause eye and skin irritation. Sittig's Handbook of Toxic and Hazardous Chemical Carcinogens reports high exposures from skin contact or inhalation may cause damage to the heart, liver, kidneys, and lungs, and may result in death. However, no quantitative data seem… more
Date: May 2015
Creator: Gibson, Jason (Jason Robert)
Item Type: Refine your search to only Thesis or Dissertation
open access

Novel Role of Trypsin in Zebrafish

Description: It has been shown previously in our laboratory that zebrafish produce trypsin from their gills when they are under stress, and this trypsin is involved in thrombocyte activation via PAR2 during gill bleeding. In this study, I investigated another role of the trypsin that is secreted from zebrafish. This investigation has demonstrated a novel role of trypsin in zebrafish. Not only did this investigation demonstrate the role of trypsin in zebrafish behavior, but also it showed that PAR2 might be … more
Date: May 2013
Creator: Alsrhani, Abdullah Falleh
Item Type: Refine your search to only Thesis or Dissertation
open access

Optical Brain Imaging of Motor Cortex to Decode Movement Direction using Cross-Correlation Analysis

Description: The goal of this study is to determine the intentional movement direction based on the neural signals recorded from the motor cortex using optical brain imaging techniques. Towards this goal, we developed a cross-correlation analysis technique to determine the movement direction from the hemodynamic signals recorded from the motor cortex. Healthy human subjects were asked to perform a two-dimensional hand movement in two orthogonal directions while the hemodynamic signals were recorded from t… more
Date: December 2019
Creator: Lebel, Cynthia
Item Type: Refine your search to only Thesis or Dissertation
open access

Optimization of Novel Culturing and Testing Procedures for Acute Effects on Acartia Tonsa and Tisbe Biminiensis

Description: Copepods comprise an ecologically important role in freshwater and marine ecosystems, which is why they are often considered an important ecotoxicological model organism. The International Organization for Standardization’s (ISO) 14669 protocol is the only guideline for the determination of acute toxicity in three European marine copepod species: Acartia tonsa. The goal of this project was to assess the feasibility of establishing and maintaining cultures of Acartia tonsa, as well as to refine … more
Date: December 2014
Creator: Ussery, Erin J.
Item Type: Refine your search to only Thesis or Dissertation

Phenotype Analysis of the CISD Gene Family Relative to Mitochondrial Function in Caenorhabditis elegans

Description: NEET proteins belong to a unique class of [2Fe-2S] cluster proteins that have been shown to participate in various biological processes such as regulating iron, reactive oxygen species and apoptosis within the cell and are localized to the mitochondria. Disruption of the mitochondrial NEET proteins are associated with different human diseases such as obesity, neurodegeneration, cancer and diabetes. In humans, a missense mutation in the CISD2 gene results in a heritable multisystem disorder term… more
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Date: December 2019
Creator: Mungwira, Chipo F
Item Type: Refine your search to only Thesis or Dissertation
open access

Phenotypic Analysis of Medicago truncatula NPF1.7 Over-Expressing Plants Grown under Different Nitrate Conditions

Description: Plants have many nitrate transporters; in the model legume Medicago truncatula, MtNPF1.7 is among them. MtNPF1.7 is important for M. truncatula growth and it has been established that MtNPF1.7 is a high affinity nitrate transporter. M. truncatula plants with mutations in MtNPF1.7 gene show defects during plants growth, with striking abnormalities in nodule development and root architecture. Nitrogen fixation is an energy expensive process; when legumes have sufficient bioavailable nitrogen like… more
Date: December 2017
Creator: Cai, Jingya
Item Type: Refine your search to only Thesis or Dissertation
open access

Phenotypic Morphological Plasticity Induced by Environmental Salt Stress in the Brine Shrimp, Artemia franciscana

Description: Phenotypic plasticity is the ability of an organism to express different phenotypes in response to biotic or abiotic environmental cues. The ability of an organism to make changes during development to adjust to changes in its environment is a key to survival. Sexually reproducing organisms that have short life cycles and that are easy to raise in the laboratory are more conducive for developmental phenotypic plasticity. Considerable research has already been carried out on the brine shrimp, Ar… more
Date: December 2015
Creator: Jones, Shaun Gray
Item Type: Refine your search to only Thesis or Dissertation
open access

Photoactivatable Quantum Dots in Super-Resolution Microscopy of Muscle

Description: Super-resolution 3D imaging was achieved using newly synthesized photoactivatable quantum dot (PAQ dot) probes. Quantum dots were modified with a novel quencher system to make them photoactivatable. The unique properties of these PAQ dots enable single-fluorophore localization in three dimensions using a confocal microscopy optical sectioning method. Myosin and tropomyosin of rabbit myofibrilar bundles were specifically labeled with the newly synthesized PAQ dot. A sufficient number of single q… more
Date: December 2010
Creator: Akel, Amal
Item Type: Refine your search to only Thesis or Dissertation
open access

Population Dynamics and Community Structure of Mosquitoes (Diptera: Culicidae) Recorded in Denton, Texas from 2005 to 2015

Description: A population survey was conducted on the mosquito species recorded in Denton, Texas for the years of 2005 to 2015. Data used in this project were obtained from an ongoing, long-term surveillance program led by the City of Denton and conducted through the University of North Texas. Research focused on the population dynamics and community structure of mosquitoes collected within urban areas of Denton, Texas in relation to certain environmental variables. A total of 80,837 female mosquitoes were … more
Date: May 2018
Creator: Hambrick, Bethany Lynn
Item Type: Refine your search to only Thesis or Dissertation
open access

Presence of Wolbachia, A Potential Biocontrol Agent: Screening for Vertebrate Blood Meal Source and West Nile Virus in Mosquitoes in the North Texas Region

Description: West Nile virus (WNV) is a geographically endemic mosquito-borne flavivirus that has spread across the United States infecting birds, mosquitos, humans, horses and other mammals. The wide spread nature of this virus is due to the ability of the mosquito vector to persist in broad, ecological diverse environments across the United States. In this study, mosquito populations in North Texas region were sampled for detection of Wolbachia, blood meal source, and WNV. The ultimate goal of this study … more
Date: August 2016
Creator: Adiji, Olubu Adeoye
Item Type: Refine your search to only Thesis or Dissertation
open access

Primary Cilia in the Oligodendrocyte Lineage

Description: oligodendrocytes migrate from the corpus callosum into the overlying cortex. The incidence of cilia did not change markedly across age groups, and did not vary consistently with the number of processes per cell, which was used as an indication of the maturation stage of OPCs and young OLs. The mean percent of Olig1 immunopositive (Olig1+) cells having cilia across ages was 33.1% + 16.5%, with all ages combined. In O4+ cells of these mice, 56.7 + 3.6% had primary cilia. If it is the case that ad… more
Date: May 2013
Creator: Hao, Yung-Chia
Item Type: Refine your search to only Thesis or Dissertation
open access

Producing a Film on Oil Spill Research for the Public

Description: The Deepwater Horizon oil drilling rig exploded on April 20, 2010, off the coast of Louisiana in the Gulf of Mexico. Following the spill, British Petroleum, leaser of the rig, set up a funding institution known as the Gulf of Mexico Research Initiative (GoMRI) to support research and understanding of the spill on the environments and peoples of the gulf. This outreach project was created alongside research of the RECOVER consortium, funded by GoMRI, to communicate what is happening within resea… more
Date: December 2018
Creator: Barnes, Emma Katherine
Item Type: Refine your search to only Thesis or Dissertation
open access

Purification of Cyanide-Degrading Nitrilase from Pseudomonas Fluorescens NCIMB 11764.

Description: Cyanide is a well known toxicant that arises in the environment from both biological and industrial sources. Bacteria have evolved novel coping mechanisms for cyanide and function as principal agents in the biosphere for cyanide recycling. Some bacteria exhibit the unusual ability of growing on cyanide as the sole nitrogen source. One such organism is Pseudomonas fluorescens NCIMB 11764 (Pf11764) which employs a novel oxidative mechanism for detoxifying and assimilating cyanide. A unique comple… more
Date: December 2010
Creator: Chou, Chia-Ni
Item Type: Refine your search to only Thesis or Dissertation
open access

Regulation of Alternative Sigma Factors During Oxidative and Ph Stresses in the Phototroph Rhodopseudomonas Palustris

Description: Rhodopseudomonas palustris is a metabolically versatile phototrophic α-proteobacterium. The organism experiences a wide range of stresses in its environment and during metabolism. The oxidative an pH stresses of four ECF (extracytoplasmic function) σ-factors are investigated. Three of these, σ0550, σ1813, and σ1819 show responses to light-generated singlet oxygen and respiration-generated superoxide reactive oxygen species (ROS). The EcfG homolog, σ4225, shows a high response to superoxide and … more
Date: August 2014
Creator: Perry, Leslie M.
Item Type: Refine your search to only Thesis or Dissertation
open access

The Relationship of Force on Myosin Subfragment 2 Region to the Coiled-Coiled Region of the Myosin Dimer

Description: The stability of myosin subfragment 2 was analyzed using gravitational force spectroscopy. The region was found to destabilize under physiological force loads, indicating the possibility that subfragment 2 may uncoil to facilitate actin binding during muscle contraction. As a control, synthetic cofilaments were produced to discover if the observations in the single molecule assay were due to the lack of the stability provided by the thick filament. Statistically, there was no difference betwee… more
Date: December 2011
Creator: Hall, Nakiuda M.
Item Type: Refine your search to only Thesis or Dissertation
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