Description: This book chapter discusses a research project to promote biocultural conservation in Cape Horn, Chile. At the southernmost tip of the Americas, the Cape Horn Biosphere Reserve (CHBR) encompasses one of the world's most pristine remaining wilderness areas and is home to the indigenous Yaghan (or Yamana) community, which featured prominently in Charles Darwin's 'Voyage of the Beagle'. Its remoteness and uniqueness, however, are threatened by the introduction of exotic species such as the North American beaver and American mink, increasing development pressures from new connectivity, resource exploitation, and the development of tourism. To implement the biosphere reserve and conserve its natural and cultural richness requires the active participation of the community, as well as linkages and integration between various disciplines and institutions. In an effort to achieve the goal of transdisciplinary integration, the authors used the strategy of identifying a charismatic species, since doing so serves to motivate people towards biodiversity conservation, to communicate ecological concepts, and to integrate both the ecological and social dimensions of sustainability. This study was developed together with the population of Puerto Williams, a town with 2200 inhabitants located on Navarino Island, and the largest human settlement within the CHBR.