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A chemical genetic screen uncovers a small molecule enhancer of the N-acylethanolamine degrading enzyme, fatty acid amide hydrolase, in Arabidopsis

Description: This article demonstrates the feasibility of using an unbiased chemical genetic approach to identify new pharmacological tools for manipulating FAAH- and NAE-mediated physiological processes in plants.
Date: January 23, 2017
Creator: Khan, Bibi Rafeiza; Faure, Lionel; Chapman, Kent D. & Blancaflor, Elison B.
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Partner: UNT College of Arts and Sciences
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Malonylation of Glucosylated N-Lauroylethanolamine: A New Pathway That Determines N-Acylethanolamine Metabolic Fate in Plants

Description: This article focuses on the gene At5g39050, which encodes a phenolic glucoside malonyltransferase 1 (PMAT1), to better understand the biological significance of N-lauroylethanolamine (NAE 12:0)-induced gene expression changes.
Date: November 17, 2016
Creator: Khan, Bibi Rafeiza; Wherritt, Daniel J.; Huhman, David; Sumner, Lloyd W.; Chapman, Kent D. & Blancaflor, Elison B.
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Partner: UNT College of Arts and Sciences
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Lipid Profiling Reveals Tissue-Specific Differences for N-Acylethanolamines and their Precursors in Mice Lacking Fatty Acid Amide Hydrolase

Description: Article on lipid profiling revealing tissue-specific differences for N-acylethanolamines and their precursors in mice lacking fatty acid amide hydrolase.
Date: September 2010
Creator: Kilaru, Aruna; Isaac, Giorgis; Tamura, Pam; Baxter, David; Duncan, Scott R.; Venables, Barney J. et al.
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Partner: UNT College of Arts and Sciences
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Crystal Structure of Thrombin in Complex with S-Variegin: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors

Description: Article on the crystal structure of thrombin in complex with s-variegin and insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors.
Date: October 2011
Creator: Koh, Cho Yeow; Kumar, Sundramurthy; Kazimirova, Maria; Nuttall, Patricia A.; Radhakrishnan, Uvaraj P.; Kim, Seongcheol et al.
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Partner: UNT College of Arts and Sciences
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Novel aromatase inhibitors selection using induced fit docking and extra precision methods: Potential clinical use in ER-alpha-positive breast cancer

Description: This article aims to identify new molecules which could block or suppress the activity of aromatase enzyme by molecular docking studies using Schrödinger-Maestro v9.3.
Date: October 10, 2016
Creator: Kumavath, Ranjith; Azad, Manan; Devarapalli, Pratap; Tiwari, Sandeep; Kar, Shreya; Barh, Debmalya et al.
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Partner: UNT College of Arts and Sciences
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Utilization of Cyanide as a Nitrogenous Substrate by Pseudomonas fluorescens NCIMB 11764: Evidence for Multiple Pathways of Metabolic Conversion

Description: Article on the utilization of cyanide as a nitrogenous substrate by Pseudomonas fluorescens NCIMB 11764 and evidence for multiple pathways of metabolic conversion.
Date: June 1, 1992
Creator: Kunz, Daniel A.; Nagappan, Olagappan; Silva-Avalos, Juan & Delong, George T.
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Partner: UNT College of Arts and Sciences
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Glucose or Altered Ceramide Biosynthesis Mediate Oxygen Deprivation Sensitivity Through Novel Pathways Revealed by Transcriptome Analysis in Caenorhabditis elegans

Description: This article discusses how RNA-sequencing analysis was performed to assess how a glucose-supplemented diet and/or a hyl-2 mutation altered the transcriptome.
Date: August 5, 2016
Creator: Ladage, Mary L.; King, Skylar D.; Burks, David J.; Quan, Daniel L.; Garcia, Anastacia M.; Azad, Rajeev K. et al.
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Partner: UNT College of Arts and Sciences
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Genome Sequences of Streptomyces Phages Amela and Verse

Description: This article describes Amela and Verse, two Streptomyces phages isolated by enrichment on Streptomyces venezuelae (ATCC 10712) from two different soil samples.
Date: February 18, 2016
Creator: Layton, Sonya R.; Hemenway, Ryan M.; Munyoki, Christine M.; Barnes, Emory B.; Barnett, Sierra E.; Bond, Alec M. et al.
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Partner: UNT College of Arts and Sciences
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Integrative Analysis of Transgenic Alfalfa (Medicago sativa L.) Suggests New Metabolic Control Mechanisms for Monolignol Biosynthesis

Description: Article on an integrative analysis of transgenic alfalfa (Medicago sativa L.) suggesting new metabolic control mechanisms for monolignol biosynthesis.
Date: May 2011
Creator: Lee, Yun; Chen, Fang; Gallego-Giraldo, Lina; Dixon, R. A. & Voit, Eberhard O.
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Partner: UNT College of Arts and Sciences
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It's not too Late for the Harpy Eagle (Harpia harpyja): High Levels of Genetic Diversity and Differentiation Can Fuel Conservation Programs

Description: Article on the harpy eagle (Harpia harpyja) and how high levels of genetic diversity and differentiation can fuel conservation programs.
Date: October 5, 2009
Creator: Lerner, Heather R. L.; Johnson, Jeff A.; Lindsay, Alec R.; Kiff, Lloyd F. & Mindell, David P.
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Partner: UNT College of Arts and Sciences
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Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma

Description: Article on the constitutive activation of proinflammatory transcription factors such as STAT3 and NF-KB that play a pivotal role in the proliferation and survival of squamous cell carcinoma of the head and neck (HNSCC).
Date: June 26, 2013
Creator: Li, Feng; Shanmugam, Muthu K.; Chen, Luxi; Chatterjee, Snehajyoti; Basha, Jeelan; Kumar, Alan Prem et al.
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Partner: UNT College of Arts and Sciences
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Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenoraft mouse model despite downregulation of proliferative biomarkers

Description: This article investigates whether garcinol, a polyisoprenylated benzophenone can chemosensitize HNSCC to cisplatin.
Date: February 28, 2015
Creator: Li, Feng; Shanmugam, Muthu K.; Siveen, Kodappully Sivaraman; Wang, Fan; Ong, Tina H.; Loo, Ser Yue et al.
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Partner: UNT College of Arts and Sciences
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