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- Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model
- Article investigates whether thymoquinone (TQ), a bioactive constituent of black seed oil, could suppress the proliferation and induce chemosensitization in human myeloma cells and xenograft mouse model. Overall, the results demonstrate that TQ can enhance the anticancer activity of bortezomib in vitro and in vivo and may have a substantial potential in the treatment of MM.
- γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mammalian target of rapamycin pathway in an orthotopic mouse model
- Article describing an investigation into whether γ-tocotrienol can abrogate angiogenesis-mediated tumor growth in hepatocellular carcinoma (HCC) and if so, through what molecular mechanisms.
- Association of Host and Microbial Species Diversity across Spatial Scales in Desert Rodent Communities
- Article describes study in which researchers employed a natural gradient of rodent species richness and quantified bacterial communities in rodent blood at several hierarchical spatial scales to test the hypothesis that associations between host and microbial species diversity will be positive in communities dominated by organisms with broad niches sampled at large scales.
- Negative Regulation of Signal Transducer and Activator of Transcription-3 Signalling Cascade by Lupeol Inhibits Growth and Induces Apoptosis in Hepatocellular Carcinoma Cells
- In this article, the authors evaluate the effect of lupeol on STAT3 signalling cascade and its regulated functional responses in hepatocellular carcinoma (HCC) cells. Constitutive activation of signal transducer and activator of transcription signalling 3 (STAT3) has been linked with survival, proliferation and angiogenesis in a wide variety of malignancies including HCC. Lupeol exhibited its potential anticancer effects in HCC through the downregulation of STAT3-induced pro-survival signalling cascade.
- Introducción a la Sección Especial de Revista Bosque. Avances de una red de sitios de estudios ecológicos a largo plazo en el suroeste de Sudamérica
- This article is the forward to a special section on long-term ecological research in Chile. It briefly introduces the main topics and ideas of each of the articles and comment on their relevance in the context of research and monitoring of Chilean ecosystems and in the perspective of global change research.
- Pulsed cooperative backward emissions from non-degenerate atomic transitions in sodium
- Article describes study which examines backward cooperative emissions from a dense sodium atomic vapor.
- Spatially Periodic Electromagnetic Force Field For Plasma Confinement and Control
- In this article, a theoretical understanding is developed of the single-particle reflection properties of a force field, considering the incident charged particles to have a non-drifting, isotropic velocity distribution. Classical trajectory Monte Carlo simulations and analytical modeling are employed. The initiation of an experimental effort to study force fields is described.
- Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING
- Article describes study in which researchers carried out comprehensive evolutionary analyses of the GMP-AMP (cGAMP) synthase (cGAS)-STING pathway.
- Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro
- The article looks at antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line.
- Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers
- This article examines the use of metal-containing polymers as a novel class of antivirals. Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth.
- An Updating System for the Gridded Population Database of China Based on Remote Sensing, GIS and Spatial Database Technologies
- Describes the development of a Spatial Population Updating System (SPUS) for updating the gridded population database of China based on remote sensing, GIS and spatial database technologies, with a spatial resolution of 1 km by 1 km.
- The First Stalin Mass Operation (1927)
- This article based on new archival documents introduces a new episode of mass operations, which took place in June and July of 1927 and was directed against the broad group of “anti-Soviet” forces. It preceded many practices of mass terror of the 1930s with judicial and extra-legal mechanisms. The goal of this article is to explain motivations, justifications, and mechanisms of this repressive campaign and to put this episode in the wider context of Soviet terror. Facing the combination of a perceived danger of war and real internal social hostility expressed in broad defeatism, both threatening the perpetuation of their governmental powers, authorities resorted to repressions. The 1927 episode highlights the factor of a perceived threat of war as a crucial motivating element in Soviet repressive tactics.
- Technical Memorandum: Lewisville Lake Watershed Protection and Management Strategies
- With a current population of just over half a million and a 2030 projected population of approximately one million, expansion throughout Denton County shows no sign of slowing down (NCTCOG). Increasingly, freshwater resources are also facing increased pressure from this urban expansion. Effective assessment and management techniques are necessary to protect the diversity of ecosystem services found within fluvial ecosystems and to mitigate current and future conditions of environmental stressor amplified by urban development. The use of various spatial analysis techniques in environmental assessment present more expedient, cost effective, and broader ranging methods of evaluation than traditional field techniques. One such novel evaluation technique is the Water Quality Corridor Management (WQCM) model, developed by the University of North Texas in cooperation with the Upper Trinity Regional Water District (UTRWD). The WQCM model is a geospatial database that utilizes GIS and remote sensing techniques to assess and prioritize stream reaches according to their overall health and sustainability. This project assessed the viability of the WQCM model in reviewing the status of stream systems, and ultimately, established an accurate mechanism for evaluating the stream corridor and surface water quality draining into Lewisville Lake, a popular recreation site and drinking water source for the urbanizing Dallas and Fort Worth metropolitan area.
- Some numerical analyses on the solubility of vanillin in Carbitol® + water solvent mixtures
- This article reports solubility values of vanillin (component 3) in 2-(2-ethoxyethoxy)ethanol (Carbitol®, component 1) + water (component 2) mixtures at five temperatures from 298.15 to 318.15 K correlated with the Jouyban-Acree model combined with van't Hoff or Apelblat equations, and obtains models in second degree regarding the mixtures compositions.
- Cotton CENTRORADIALIS/TERMINAL FLOWER 1/SELF-PRUNING genes functionally diverged to differentially impact plant architecture
- This article characterizes the CETS gene family from tetraploid cotton in order to understand the regulation of cotton architecture and exploit these principles to enhance crop productivity.
- An assessment of MODIS Collection 5 global land cover product for biological conservation studies
- This paper identifies the uncertain areas and figures out the problematic land cover types in the MODIS Collection 5 global land cover dataset without ground validation samples.
- The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells
- This article reveals an interaction between the two anti-apoptotic proteins iASPP and NAF-1, which are overexpressed in many types of cancer cells and tumors.
- Attributive Constructions in Saanich
- This paper gives a descriptive sketch of the various structures of the Saanich dialect of North Straits Salish has to express attribution and to look at structures similar to those designated relative clauses in other Salishan languages from a cross-linguistic and pan-Salishan point of view.
- Auxiliaries and other grammatical categories in Klallam
- This paper describes a close look at the distribution in constructions of the closed class of complex predicate forming stems in Klallam traditionally called 'auxiliaries.'
- Curvature Bundle Morphisms for Hypersurface Generalized Dirac Operators
- This article establishes uses a Gauss-like relationship to examine how the curvature bundle morphisms relate.
- “We Need an Even Bigger One”: Disasters of Inequality in Postquake Kathmandu Valley
- This article reflects on the 2015 earthquakes in Nepal.
- Klallam Demonstratives
- This paper updates and expands upon the componential analysis provided by Thompson and Thompson 1071 of the Klallam language's set of demonstrative determiners.
- Klallam from A to B
- This paper describes a typology of paths.
- Language and Dialects in Straits Salishan
- This paper compares the Klallam and Northern Straits languages within the Straits Salishan group of languages and dialects.
- The Major Processes Affecting Klallam Vowels
- This paper provides a more detailed description of the major processes affecting the Klallam vowels.
- Some Klallam Paradigms
- This paper presents the various transitive and intransitive paradigms of Klallam to make this data and grammatical information available preliminary to a thorough descriptive treatment.
- Serial Verbs and Complex Paths in Klallam
- This article describes and illustrates the construction of complex paths and discusses the place of Klallam in a typology of motion events.
- Traditional Personal Names in Klallam
- This paper describes the phonology, morphology, and syntax of personal names in Klallam, and includes a description of the importance of personal names in Klallam.
- On the exact solution of certain generic nonlinear polynomial systems with cyclic symmetry
- This article examines how in view of the fundamental theorem of algebra and basic Galois theory solving nonlinear systems of polynomial equations exactly means in general reducing them to one single equation in one variable.
- A Computerized Concordance/Dictionary
- This paper illustrates an example of how the linguist's data organization burden can be greatly alleviated with the help of a computer.
- Methods to evaluate rare variants gene-age interaction for triglycerides
- This article discusses the development of two statistical methods to test the gene environment interaction effect of rare variants.
- Bridging Waves and Crucial Events in the Dynamics of the Brain
- This article establishes an approach that simultaneously detects the statistical properties of crucial events and a connection with the wave-like nature of brain dynamics.
- Methods and results from the genome-wide association group at GAW20
- This article reports on promising statistical approaches and findings of the members of the Genome-wide Association Study group applied on real and simulated data which encompass the current topics of epigenetic and pharmacogenomics.
- What Was Damaged?: Taking Sacred Ecology into Account in Environmental Impact Assessment
- This article argues that any analysis of environmental impacts on indigenous communities must also consider the ways in which changes in environmental quality have harmed indigenous ways of sacredly connecting to the environment.
- "With Anything Manmade There is Going to be Danger": The Cultural Context of Navajo Opinions Regarding Snowmaking on the San Francisco Peaks
- This article explores the perspectives of Navajo living in Leupp, Arizona, who object to a plan to use artificial snow on the San Francisco peaks.
- A China data set of soil properties for land surface modeling
- This article describes the use of a comprehensive 30x30 arc-second resolution gridded soil characteristics data set of China for land surface modeling.
- Spatio-Temporal Distribution of Malaria in Yunnan Province, China
- This article describes the use of GIS techniques to conduct temporal and spatial analyses of both P. vivax and P. falciparum malaria to understand the trend and dynamics of transmission, to identify risk periods and areas, and to determine environmental factors associated with increased risk of malaria.
- Excited State Charge Separation in Solution and in Electropolymerized Films of Terthiophene-Fullerene Dyad and Phenothiazine-Terthiophene-Fullerene Triad
- This article reports synthesis, X-ray structure and excited state events occurring in a terthiophene-C₆₀ dyad (TT-C₆₀), and a phenothiazine-terthiophene-C₆₀ triad (PTZ-TT-C₆₀).
- Sacredness and Ski Resorts: Being Human and Being in Conflict
- This paper situates anti-snowmaking sentiments in Navajo concepts of sacredness.
- "With dignity we will fight!" Worker Self-managed Hotel BAUEN Once Again Under Threat
- This article discusses the efforts of self-managed workers in Hotel BAUEN in Buenos Aires, Argentina to appeal for international support as they confront the threat of eviction.
- Legislative Ambiguity and Ontological Hierarchy in US Sacred Land Law
- This article demonstrates instances in which sacred site law was construed so narrowly as to a priori preclude indigenous ways of knowing, particularly in regards to the nature of land, use of sacred objects, and pollution.
- Bird watching in China reveals bird distribution changes
- This article describes the development of the China Bird Watching Database and its use to understand bird distribution changes.
- The Lancet Countdown: tracking progress on health and climate change
- This article outlines the potential indicators and indicator domains to be tracked by the Lancet Countdown working groups, with suggestions on the methodologies and datasets available to achieve this end.
- Health and Climate Change: policy responses to protect public health
- This article summarizes key messages from the 2015 Lancet Commission on Health and Climate Change, accompanied by ten underlying recommendations to accelerate action in the next 5 years.
- Monitoring Annual Urban Changes in a Rapidly Growing Portion of Northwest Arkansas with a 20-Year Landsat Record
- This article employs a time series Landsat stack covering the period from 1995 to 2015 to detect the urban dynamics in Northwest Arkansas via a two-stage classification approach.
- The Association between Hantavirus Infection and Selenium Deficiency in Mainland China
- This article studies the role of selenium concentration in hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses, using a multidisciplinary approach combining ecological analysis with preliminary experimental data.
- Combining Spatial-Temporal and Phylogenetic Analysis Approaches for Improved Understanding on Global H5N1 Transmission
- This article reports an interdisciplinary effort that combines the geospatial informatics approach with a bioinformatics approach to form an improved understanding on the transmission mechanisms of H5N1 virus.
- Meta-discoveries from a synthesis of satellite-based land-cover mapping research
- This article provides a spatialized database of scientific literature in English about land-cover mapping.
- Mapping Mountain Pine Beetle Mortality through Growth Trend Analysis of Time-Series Landsat Data
- This article presents a forest growth trend analysis method that integrates Landsat temporal trajectories and decision tree techniques to derive annual forest disturbance maps over an 11-year period.
- Soil Diversity as Affected by Land Use in China: Consequences for Soil Protection
- This article reports the first effort to assess the impact of land-use change on soil diversity for the entire nation of China.