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An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL indced apoptosis through the induction of death receptors and downregulation of cell survival proteins

Description: Article on an anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins.
Date: May 23, 2013
Creator: Subramaniam, Aruljothi; Loo, Ser Yue; Rajendran, Peramaiyan; Manu, Kanjoormana Aryan; Perumal, Ekambaram; Li, Feng et al.
Partner: UNT College of Arts and Sciences
open access

Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers

Description: This article examines the use of metal-containing polymers as a novel class of antivirals. Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth.
Date: May 27, 2011
Creator: Roner, Michael R.; Carraher, Charles E., Jr.; Shahi, Kimberly & Barot, Girish
Partner: UNT College of Arts and Sciences
open access

ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and c-Myc to reduce breast cancer proliferation

Description: This article shows that miR196a was highly expressed in ER+MCF-7 breast cancer cells when compared to normal mammary gland cells, with expression levels negatively correlating to ANXA1.
Date: April 20, 2016
Creator: Yuan, Yi; Anbalagan, Durkeshwari; Lee, Lay Hoon; Samy, Ramar Perumal; Shanmugam, Muthu K.; Kumar, Alan Prem et al.
Partner: UNT College of Arts and Sciences
open access

Arabidopsis Thaliana--Myzus Persicae Interaction: Shaping the Understanding of Plant Defense Against Phloem-Feeding Aphids

Description: This review article summarizes recent studies that have exploited the compatible interaction between Arabidopsis and the green peach aphid (GPA) to understand the molecular and physiological mechanisms utilized by plants to control aphid infestation, as well as genes and mechanisms that contribute to susceptibility.
Date: July 1, 2013
Creator: Louis, Joe & Shah, Jyoti
Partner: UNT College of Arts and Sciences
open access

Biochemical and molecular-genetic characterization of SFD1’s involvement in lipid metabolism and defense signaling

Description: Article describes study which sought to to determine if the dihydroxyacetone phosphate (DHAP) reductase activity and chloroplast localization are required for the Arabidopsis thaliana SFD1 (suppressor of fatty acid desaturase deficiency1) gene’s involvement in galactolipid metabolism and systemic acquired resistance (SAR) signaling.
Date: February 7, 2012
Creator: Lorenc-Kukula, Katarzyna; Chaturvedi, Ratnesh; Roth, Mary; Welti, Ruth & Shah, Jyoti
Partner: UNT College of Arts and Sciences
open access

Bioinformatics tools for cancer metabolomics

Description: This review focuses on the use of different bioinformatics tools in cancer metabolomics studies.
Date: January 12, 2011
Creator: Blekherman, Grigoriy; Laubenbacher, Reinhard; Cortes, Diego F.; Mendes, Pedro; Torti, Frank M.; Akman, Steven et al.
Partner: UNT College of Arts and Sciences
open access

Borrelia, Ehrlichia, and Rickettsia spp. in Ticks Removed from Persons, Texas, USA

Description: This article analyzes the frequency and identity of pathogens and bacterial agents in ticks removed from humans and subsequently submitted to the Texas Department of State Health Services, Zoonosis Control Program, from October 1, 2004, through September 30, 2008.
Date: March 10, 2010
Creator: Williamson, Phillip C.; Billingsley, Peggy M.; Teltow, Glenna J.; Seals, Janel P.; Turnbough, Meredith A. & Atkinson, Samuel F.
Partner: UNT College of Arts and Sciences
open access

Botulinum Toxin Suppression of CNS Network Activity In Vitro

Description: Article on botulinum toxin suppression of CNS network activity in vitro.
Date: February 12, 2014
Creator: Pancrazio, Joseph J.; Gopal, Kamakshi V.; Keefer, Edward W. & Gross, Guenter W.
Partner: UNT College of Arts and Sciences
open access

BOV - a web-based BLAST output visualization tool

Description: Article discussing research on BOV, a web-based BLAST output visualization tool.
Date: September 15, 2008
Creator: Gollapudi, Rajesh; Revanna, Kashi V.; Hemmerich, Chris; Schaack, Sarah & Dong, Qunfeng
Partner: UNT College of Arts and Sciences
open access

Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4

Description: This article describes findings that demonstrate the affect of diosgenin (DG) on inhibiting the resilient breast cancer stem cells (CSCs) which could provide a benchmark for the development of DG-based therapies in breast cancer treatment.
Date: March 20, 2017
Creator: Bhuvanalakshmi, G.; Basappa; Rangappa, Kanchugarakoppal S.; Dharmarajan, Arunasalam; Sethi, Gautam; Kumar, Alan Prem et al.
Partner: UNT College of Arts and Sciences
open access

C. Elegans and Mutants With Chronic Nicotine Exposure as a Novel Model of Cancer Phenotype

Description: This article provides evidence in support of C. elegans as initial in vivo model to study nicotine and its effects on oncogenic mutations identified in humans.
Date: November 17, 2015
Creator: Kanteti, Rajani; Dhanasingh, Immanuel; El-Hashani, Essam; Riehm, Jacob J.; Stricker, Thomas; Nagy, Stanislav et al.
Partner: UNT College of Arts and Sciences
open access

Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis

Description: This article reports the first physiological 2Fe-2S cluster acceptor for both NEET proteins as human Anamorsin (also known as cytokine induced apoptosis inhibitor-1; CIAPIN-1).
Date: October 8, 2015
Creator: Lipper, Colin H.; Paddock, Mark L.; Onuchic, José N.; Mittler, Ron; Nechushtai, Rachel & Jennings, Patricia A.
Partner: UNT College of Arts and Sciences
open access

Cardiac and metabolic physiology of early larval zebrafish (Danio rerio) reflects parental swimming stamina

Description: Article describes experiment in which mature adult zebrafish (Danio rerio) were subjected to a swimming performance test that allowed separation into low swimming stamina or high swimming stamina groups in order to determine if inherited traits that support enhanced swimming stamina in offspring appear only in juveniles and/or adults, or if these traits actually appear earlier in the morphologically quite different larvae.
Date: February 24, 2012
Creator: Gore, Matthew & Burggren, Warren W.
Partner: UNT College of Arts and Sciences
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