UNT Theses and Dissertations - 609 Matching Results
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- The Polarographic Study of P-nitroacetophenone
- The purpose of this investigation is to study the polarographic characteristics of p-nitroacetophenone.
- Hydantoins as Anticonvulsants. VII. 5-Substituted-Aryloxy Derivatives of 5-Phenylhydantoin
- This thesis discusses hydantoins as anticonvulsants. VII. 5-Substituted-aryloxy derivatives of 5-phenylhydantoin.
- 1-(4, 4'-Dinitrodiphenylmethyl)-Piperidines; 1-(4-Nitrobenzyl)-and 1-(4-Nitrobenzoyl)-Piperdines
- This study experiments with the methods of 1-(4, 4'-Dinitrodiphenylmethyl)-Piperidines; 1-(4-Nitrobenzyl)-and 1-(4-Nitrobenzoyl)-Piperdines.
- Bonding Studies on Organolithium Compounds
- This study is concerned with the nature of the relatively unusual bonding which occurs in organolithium compounds as a direct result of the oligomerization and possible explanations for that bonding.
- Synthesis of Ether-free Organomagnesium Compounds
- At the time this work was begun, there was some confusion about the technique necessary for the successful synthesis of organomagnesium compounds in hydrocarbon solvents and without solvents. It was decided to repeat the work of Bryce-Smith and Zakharkin. Thus began the study of the synthesis of organomagnesium compounds without solvents; the study of the reaction products of these organomagnesium compounds in hydrocarbons plus 2-butanone compared to the reaction products of the corresponding etheral Grignard reagent plus 2-butanone; and a preliminary study of the nature of these organomagnesium compounds in hydrocarbon solvents.
- Some Studies Involving Pyridine N-oxide Reductase
- The study herein described involved the detection of pyridine N-oxide reductase activity in cell-free extracts of E. coli 9723, the determination of co-factors necessary for the enzymatic process, a study of the optimum conditions for enzyme catalysis, and a general characterization of the enzyme.
- Synthesis and Study of Certain Amino Acids Containing the Pyridine Ring
- This study reported herein involves the synthesis and determination of certain biological activities of 4,5-dihydroxy-2-pyridinealanine and the synthesis of 3-pyridine-N-methylalanine.
- Some Studies of Tryosinase Activity in Streptomyces Antibioticus
- The study reported herein concerns itself with the isolation of melaninless mutants of S. antibioticus, ATCC, 3723, and with the demonstration that at least one of the sites of mutation involves that of the enzyme, tyrosinase.
- Preparation of N-Substituted Hydroxylamines from Oxaziridines
- In many series of compounds, intensity of biological activity and chemical reactivity are proportional. Generally whenever a alkyl group replaces a reactive hydrogen atom, as would be the case for an N-substituted hydroxylamine as compared to hydroxylamine, the over-all biological activity of the resulting compound is lower than that of its nonalkylated analogue. Since toxicity and physiological activity are not proportional, this comparison can only suggest possible types of derivatives to prepare and test.
- Magnetic Properties of Oxovanadium(IV) Complexes of Substituted N-(Hydroxylalkyl) Salicylideneimines
- A series of oxovanadium(IV) complexes of Schiff bases derived from substituted salicylaldehyde and aminoalcohols has been prepared and characterized. The Schiff bases coordinate through 0, N, and 0 as tridentate bivalent ligands. The primary purpose of the investigation is to describe the structure and bonding in these complexes. The subnormal magnetic properties of the complexes provide much information about both the structure and the bonding in the complexes.
- Synthesis of Certain Aminooxy Compounds
- The research described herein is concerned with the synthesis of certain organic compounds which have the amino-oxy grouping and are related in structure to the naturally occurring amines, putrescine, spermidine and spermine.
- Oxovanadium(IV) Complexes of Substituted N-(2-Thiophenyl)Salicylideneimine
- In an effort to study the spectral, magnetic, and stereochemical properties of vanadyl complexes, both a new series of vanadyl complexes derived from type (VII) ligands with subnormal magnetic moment and from type (VIII) ligands with normal magnetic moment are synthesized and characterized.
- Corrosion Inhibition with Quaternary Amines
- This thesis describes experiments made to test the corrosion inhibition of quaternary amines on steel.
- ESR Studies of Group IV Substituted Anilines
- The purpose of the investigation described herein was to investigate the degree of delocalization of the unpaired electron in ion radicals formed in the oxidation process of compounds with aromatic rings connected by means of various groups and atoms not entering the ring; then, to establish the relationship of coupling constants in radical cations with substituent σ values. The parent cation radical, in which the co-planar ion was derived from N,N-dimethylaniline, was selected in order to maximize the substituent effects on coupling constants and to obtain couplings at several positions (specifically, CH3, N, and ring protons).
- Pyridine Derivatives of Naphthoquinone
- This paper deals with the preparation of pyridinium derivatives of naphthoquinone. The starting material was 2,3-dichloro-1,4-naphthoquinone, and it was reacted with pyridine and 4-n-alkyl-pyridine derivatives.
- The Adsorption of Radioactive Isotopes on Specific Precipitates
- The purpose of this investigation is to reveal the effects of certain factors affecting adsorption on some specific precipitates. It is hoped that the choice of precipitate types will enable extension of the information gained here to other precipitates similar to those investigated.
- Amino Acid Complexes of Rhodium(III)
- This thesis will explore and study rhodium, a group VIII element that has rarely been studied.
- Preparation of 4-Amino-3-Hydrazino-5-Methyl-s-Triazole Dihydrochloride and Condensation Products
- The procedure of Takimoto, Denault, and Hotta was followed in order to prepare 4-amino-3-hydrazino-5-methyl-s-triazole hydrochloride (II) and its precursor, triamino-guanidine hydrochloride (I).
- Mercury-Sensitized Photochemical Reactions of Isopropyl Alcohol
- This thesis discusses the mercury-sensitized photochemical reactions of isopropyl alcohol.
- Synthesis, Stability, and Reactions of Dichloroketene
- The primary objective of this work was to prepare dichloroketene.
- Synthesis of Selected 2-imidazolines
- Since Djerassi and Scholz found that 2-(aryloxy-methyl)imidazolines and their hydrochloride salts exhibit vasoconstrictive properties, the 1,2-(I) 1,3-(II) and 1,4-bis-(2-imidazolinylmethoxy) benzene (III) analogs (Fig. 1, p.2) were chosen for synthesis in order to test them for their effective vasoconstrictive characteristics and for whatever other physiological properties they might exhibit.
- Nitrogen Derivatives of Naphthoquinone
- This thesis investigates nitrogen derivatives of naphthoquinone.
- Barbituric Acids. VI. 5-substituted-mercapto Derivatives of 5-ethylbarbituric Acid
- The reaction of 5-bromo-5-ethylbarbituric acid with mercaptan and pyridine in cold ether solution was studied and was found to be satisfactory for the preparation of the compounds reported in this work.
- The Coupling Mechanism in the Organolithium-Organic Monofluoride Reaction
- In this work, the principal concern will be with the coupling reaction and it is anticipated that the other reactions referred to above will be considered further when products of the RX-R'Li reactions are discussed.
- Self-Diffusion of Na-²² in Molten PbCl₂-NaCl Mixtures
- This thesis contains the exploration and investigation of self-diffusion of Na-22 in Molten PbCl2-NaCl mixtures.
- Thermal Decomposition of Alkyllithium Compounds in the Pure State
- This thesis is concerned with the thermal decomposition of a series of alkyllithium compounds in the pure state in an attempt to determine the relative stability of alkyllithium compounds and to examine the mechanism of the elimination reaction.
- Self-diffusion of Pb210 and Cl36 in Molten PbCl2-KCl Mixtures in the Region of the Compound 2PbCl2-KCl
- The specific goal of the investigation was the measurement, as a function of temperature, of the self-diffusion coefficients of Pb210 and Cl36 in PbCl2-KCl compositions in the region of the first compound, and to calculate from these data the activation energy necessary for the diffusion of these ions.
- Barbituric Acids. VII. 5-alkyl-derivatives of 5-ethoxy-barbituric Acid
- A great deal of research has been devoted in recent years to the search for new drugs for the treatment of epilepsy and related convulsive disorders. This emphasis is occasioned by the fact that no one drug is effective for all patients, and also by the fact that the toxicity of a drug varies considerably from one patient to another. Among the most effective drugs are certain members of the hydantoin and barbituric acid series. For some time there has been in progress in this laboratory an investigation of members of these two series in which a hetro atom attached directly to the hetrocyclic nucleus is introduced into the side chain at position five of these two series.
- The Synthesis of Benzo(d)pyrido(a)-benzimidazole-5,12-quinone
- The present investigation yielded an orange product upon refluxing 2-butyramido-3-chloro-1,4-naphthoquinone and 2-aminopyridine in ethanol. When this material was purified, by recrystallization from glacial acetic acid, the melting point was 306 [degrees]. This compound has been shown to be benzo(d)pyrido(a)-benzimidazole-5,12-quinone by the present investigation.
- The Preparation of Pyridinium Derivatives by the Knoevenagel Condensation
- An attempt is made in the work described in this paper to extend the series started by Hall and Platas by means of a Knoevenagel condensation between 3-hydroxy-1,4-naphtho-quinone-2-(4-methylpyridinium) anhydride and various aromatic aldehydes giving rise to a series of unsaturated substituents on the four position of the pyridine ring.
- Synthesis, Characterization, and Optical Isomerism of Some Cobalt (III) Complex Compounds
- This thesis investigates the synthesis, characterization, and optical isomerism of some cobalt (III) complex compounds.
- Base Effects on the Thermal Decomposition of Sec-butyllithium Solutions
- The pyrolysis of sec-butyllithium in solution was studied in an attempt to understand the loss of stereo-specificity and the atypical kinetics that have been reported. Additionally, the effect of added lithium alkoxides was studied to determine their effects on the highly reactive sec-butyllithium substrate.
- Electronic Effects in Dihaloketenes
- The objective of this investigation was to determine the electronic effects of the halogen atoms in dihaloketenes such as dichloroketene and dibromoketene.
- Cycloadditions of Dichloroketene
- An investigation of the cycloaddition behavior of dichloroketene with various types of olefins seemed in order to determine if dichloroketene behaved similarly to dialkylketenes. It was anticipated that a study of this type would indicate the reactivity of dichloroketene to various types of olefinic compounds and thus establish if the ease of cycloaddition with dichloroketene parallels the nucleophilicity of the olefin as it does in dialkylketenes.
- Synthesis of 1-Amino-2-Hydroxycyclopentanecarboxylic Acid
- This investigation involved the synthesis of 1-amino-2-hydroxycyclopentanecarboxylic acid, a potential structural analog of the natural amino acids, serine and threonine. The title compound also includes the structural features present in an established antitumor agent, cycloleucine.
- Amine Derivatives of 3-chloro-5(8?)-nitro-1,4-naphthoquinone
- This work deals with the preparation of amine derivatives of 3-chloro-5(8?)-nitro-1,4-naphthoquinone which are to be tested for anti-tubercular activity by Parke, Davis and Company.
- The Synthesis and Reduction of Some N-Phenacylpyridines
- This study explores the synthesis and reduction of some n-phenacylpyridines and is an investigation of various derivatives.
- Hydantoins as Anticonvulsants. V. 5-Substituted-Amino Derivatives of 5-Phenylhydantoin
- This thesis describes the preparation of 5-substituted-amino derivatives of 5-phenylhydantoin. The hydantoin derivatives are to be tested for anticonvulsant activity by the Pharmacology Department of the Eli Lilly Company of Indianapolis, Indiana.
- The Photochemical Reactions of 2,7-dimethyloctane
- This thesis is a study of the photochemical reactions of 2,7-dimethyloctane.
- Nitrogen Derivatives of Naphthoquinone
- A series of nitrogen derivatives of 1,4-naphthoquinone, which are structurally similar to the compounds of Hall, has been prepared by this worker. In general, the amido groups are those of the long-chain, fatty acids, and it is believed they will have increased physiological activity. These compounds are to be tested for medicinal activity by Parke-Davis and Company.
- The Adsorption of Radioactive Isotopes on Precipitates
- This thesis concerns the investigation of radioisotopes as indicators for precipitation reactions. As a precipitate forms in the presence of a radioisotope, adsorption may take place on its surface. If this adsorption changes markedly at the stoichiometric point it will be possible to use this variation as an indicator for the reaction.
- Hydantoins as Anticonvulsants. VIII. 5-Alkylmercapto Derivatives of 3-Methyl-5-Phenylhydantoin
- Recent years have seen a rapid increase in the search for new compounds to be employed in the treatment of convulsions associated with epilepsy and related ailments. The properties desired are a higher degree of effectiveness and lower toxicity than those already in use. This thesis describes the effect of methylation of the 5-alkylmercapto-5-phenylhydantoins.
- Hydantoins as Anticonvulsants. VI. 5-Substituted-Alkoxy Derivatives of 5-Phenylhydantoin
- No derivatives of 5-phenylhydantoin with an oxygen atom attached directly in the five position of the hydantoin nucleus have been found in the literature. It was therefore considered of interest to synthesize a series of compounds of this type to determine the effect of the change of the position of the oxygen atom on anticonvulsant activity.
- Reactions of N-(Substituted) Phthalimides with n-Alkylamines
- The initial purpose of this study was to determine if steric problems would account for the difference in the products obtained in the reaction of the N-(substituted)phthalimide with low and high molecular weight amines.
- Characterization of Ionic Liquid As a Charge Carrier for the Detection of Neutral Organometallic Complexes Using Electrospray Ionization Mass Spectrometry
- A novel application of ionic liquid as a charge carrier for the analysis and detection of neutral organometallic complexes using a mass spectrometer has been presented. The mass spectrometer detects only charged compounds which raise a difficulty in analyzing a neutral molecule that lacks a basic site to associate with charge. Therefore, an effective way of providing charge has always been an area of keen interest in the field of mass spectrometry. Ionic liquids have a very fascinating property of forming a cation-? interaction with other molecules to give a charged complex. In order to take advantage of this, it is important to know the geometric structure of the complex. Advanced methodologies like hydrogen-deuterium exchange and computational calculations have been used assisting in better understanding of the structure of the ionic liquid complexes.
- Addition Reactions of Some Aromatic Aldazines
- The paper explores the conclusion that the addition compound was bicyclic, and that the addition of each of the two moles of cyanic acid was dependent upon the other.
- A Study of the Bromination Products of Phenylmercaptoacetic Acid
- This investigation was begun in order to determine the nature of the 104 degree melting compound prepared by Ashmore and to determine which isomers and their relative amounts are produced during bromination of phenylmercaptoacetic acid.
- Synthesis of Some Amine Steroid Derivatives
- The preparation of 3B-(2-mercaptoethylamino)-cholestane was set as the goal of this thesis project.
- Preparation of Alkoxy Derivatives of 2-Chloro-1,4-Naphthoquinone and 2-Chloro-5(8?)- Nitro-1,4-Naphthoquinone
- This paper studies the the synthesis of certain alkoxy compounds of 2,3-dichloro-1,4-naphthoquinone that can be considered chemotherapeutic agents.
- Synthesis of Polyaldehydes
- Part one of this thesis concerns the polymerizability of some α,β-unsaturated monaldehydes and also relates the synthesis of some new polyaldehydes which have not been reported in the literature. Part two concerns the polymerization of glyoxal, the simplest dialdehyde, and the structure elucidation of this new polymer.